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PPHM - TUSTIN, Calif., Jun 4, 2003 /PRNewswire-FirstCall via COMTEX/ --
Peregrine Pharmaceuticals (Nasdaq: PPHM) announced today the publication of a report showing that certain chemical agents make tumor blood vessels more responsive to its Vascular Targeting Agent (VTA) effector called truncated tissue factor (tTF). Peregrine is developing truncated tissue factor as an anticancer compound that selectively causes blood clots to form within tumor blood vessels, thus cutting off oxygen and nutrients to tumor cells and causing tumor cell death. The new research article was published in the current issue of Arteriosclerosis Thrombosis Vascular Biology.
Pre-clinical data on Peregrine's VTA technology previously published in Science showed that antibodies attached to tTF had dramatic anti-tumor effects. In the Science study, 38% of treated mice had complete tumor regressions. An additional 24% of the mice treated had at least a 50% reduction in tumor mass. In the current published report, tumor blood vessels in animals pre-treated with a chemical agent formed blood clots more easily when administered truncated tissue factor. Blood vessels in normal tissues were not blocked following pretreatment and administration of the tTF. This study indicates that the predisposition of tumor blood vessels toward clotting can be further increased, which could lead to VTA treatments with enhanced safety and efficacy.
The new article, titled 'Soluble Tissue Factor Induces Coagulation on Tumor Endothelial Cells In Vivo if Co-Administered With Low-Dose Lipopolysaccharides,'concluded that 'there are two ways of selective coagulation induction on the surface of intact endothelial cells: (1) via specific antibody directed targeting and (2) via coagulation induction by soluble Tissue Factor (TF) without a functional targeting moiety when additional factors are present that induce local upregulation of endogenous TF and local generation of factor VIIa. Both ways might be exploited for therapeutic approaches in the treatment of cancer.'This research was conducted by a third party not affiliated with or supported by Peregrine.
Steven King, Peregrine's president and CEO, said, 'This research gives us additional insight into ways to enhance our VTAs in treating cancer. This is important because it further identifies the mechanisms in which truncated tissue factor may create blood clots within tumors. More importantly, it indicates that there may be ways to further enhance the effectiveness of truncated tissue factor-based VTAs without compromising safety.'
Philip Thorpe, Ph.D., a co-inventor of the VTA technology, said, 'This work indicates that it may be possible to enhance the pro-thrombotic (pro- coagulation) conditions that naturally exist within solid tumors without inducing normal blood vessels to become pro-thrombotic. As a monotherapy, tTF based VTAs achieve almost total occlusion of tumor blood vessels in animal models. By using tTF based VTAs in combination with existing anti-cancer agents, we may be able enhance the safety and efficacy of this treatment approach.'
About Truncated Tissue Factor
The blood coagulation cascade (blood clotting) is a normal process that the body uses to stop the flow of blood from damaged tissue. When blood vessels are damaged during injury, factors in the blood come into contact with Tissue Factor (TF) found on cells normally found outside the blood vessels. TF is a receptor protein that is the initiator of the extrinsic pathway of the blood clotting. A truncated derivative of tissue factor (tTF) has been developed by Peregrine in which the portion of the TF molecule that tethers it to the surface of cells has been removed. Since tTF is soluble (not associated with a cell membrane that is necessary for induction of clotting), the tTF is usually inactive when injected into the blood stream. In Peregrine's VTAs, a targeting antibody is substituted for the membrane attachment region of the TF molecule allowing it to be selectively delivered to tumor blood vessel cell surfaces where it can initiate clotting that results in an avalanche of tumor cell death.
About Vascular Target Agents -- The Next Generation of Cancer Therapy
Virtually all detectable tumors rely on a vascular network to obtain oxygen and nutrients, and disruption of this network can have a devastating effect on a tumor. In pre-clinical animal studies, VTAs have shown to be potent anti-cancer agents that act by cutting off the supply of oxygen and nutrients to tumor cells by causing blood clots to form within the tumor's blood supply network. VTAs localize within the tumor vasculature by selectively binding to the flat endothelial cells that line tumor blood vessels. Once the VTA binds to its target, it initiates thrombosis (blood clotting) through a coagulation cascade, which leads to complete clotting of the tumor blood vessels within a matter of minutes. Because blockage of a single capillary results in the destruction of thousands of tumor cells, only a small quantity of VTAs localized in the tumor's vascular system may cause an avalanche of tumor cell death.
Vascular targeting agents offer several advantages as potentially powerful anti-cancer treatments. By targeting receptors unique to tumor cell vasculature, VTAs can kill tumors by cutting off oxygen and nutrients without causing damage to surrounding healthy tissue. Additionally, VTAs reduce the risk of potential side effects by operating at lower dosages than traditional cancer therapies because they do not need to penetrate the innermost layer of a tumor to take effect. Lastly, while drug resistance caused by the instability and mutability of cancer cells is a significant problem with conventional therapies that target tumor cells, cells targeted by VTAs do not mutate to become drug resistant.
I like that one .... MORE ....!
Glad to help, Twister ..... ( I ) need it ....!!
CDIK - Press ReleaseSource: Coronado Industries Inc.
Coronado Industries Sets European Meetings
Tuesday June 3, 1:59 pm ET
FOUNTAIN HILLS, Ariz.--(BUSINESS WIRE)--June 3, 2003--Coronado Industries Inc. (OTC BB: CDIK), a manufacturer of proprietary pneumatic devices for the treatment of glaucoma, announced today that its chief executive officer, G. Richard Smith, will be traveling to Europe on Thursday, June 5. Smith will be attending pre-arranged meetings with both interested parties for the distribution of our patented "PNT" device and with key European personnel with the ability to significantly advance our further efforts of distribution.
These meetings have been pre-arranged by our newly appointed Director of Operations John W. Sharkey, Ph.D.
"The speed that this man pulls things together in is incredible," stated Gary Smith, president of Coronado Industries, "but that is exactly why we were so excited about his coming on board with our company."
"I am extremely encouraged by the meetings that I will be attending and feel that the outcome of these meetings will have a very positive effect on the future of this company. There is no doubt in my mind that Dr. Sharkey has put us on the fast track to success and that the train is about to leave the station," said G. Richard Smith.
Coronado Industries, through its wholly owned subsidiary Ophthalmic International, focuses on the development and testing of a patented procedure, Pneumatic Trabeculoplasty (PNT(TM)), a non-invasive, highly effective, and low-cost alternative to traditional treatments.
PNT, a two-minute non-invasive procedure, is currently being evaluated as a cost-effective alternative for the treatment of the most common types of glaucoma: open angle and pigmentary. During PNT, a suction device is applied to the eye for two minutes with the intention of reducing intraocular pressure.
CDIK - Press ReleaseSource: Coronado Industries Inc.
Coronado Industries Sets European Meetings
Tuesday June 3, 1:59 pm ET
FOUNTAIN HILLS, Ariz.--(BUSINESS WIRE)--June 3, 2003--Coronado Industries Inc. (OTC BB: CDIK), a manufacturer of proprietary pneumatic devices for the treatment of glaucoma, announced today that its chief executive officer, G. Richard Smith, will be traveling to Europe on Thursday, June 5. Smith will be attending pre-arranged meetings with both interested parties for the distribution of our patented "PNT" device and with key European personnel with the ability to significantly advance our further efforts of distribution.
These meetings have been pre-arranged by our newly appointed Director of Operations John W. Sharkey, Ph.D.
"The speed that this man pulls things together in is incredible," stated Gary Smith, president of Coronado Industries, "but that is exactly why we were so excited about his coming on board with our company."
"I am extremely encouraged by the meetings that I will be attending and feel that the outcome of these meetings will have a very positive effect on the future of this company. There is no doubt in my mind that Dr. Sharkey has put us on the fast track to success and that the train is about to leave the station," said G. Richard Smith.
Coronado Industries, through its wholly owned subsidiary Ophthalmic International, focuses on the development and testing of a patented procedure, Pneumatic Trabeculoplasty (PNT(TM)), a non-invasive, highly effective, and low-cost alternative to traditional treatments.
PNT, a two-minute non-invasive procedure, is currently being evaluated as a cost-effective alternative for the treatment of the most common types of glaucoma: open angle and pigmentary. During PNT, a suction device is applied to the eye for two minutes with the intention of reducing intraocular pressure.
Just heard THAT ONE .... A GEM .... !!
CCGI - NEW YORK, Jun 3, 2003 /PRNewswire-FirstCall via COMTEX/ --
Pivotal Self-Service Technologies, Inc. (OTCBB: PVSS) announced today that Prime Battery Products, a wholly owned subsidiary of PVSS, and Collectible Concepts Group (CCGI) have established and created MightyVolt(TM).
MightyVolt(TM) is a joint venture that was developed by the two companies for the purpose of engaging in the business of marketing batteries and related products that include the display of licensed logos, images, and brand names. The batteries being used for the joint venture are fully tested and compare very favorably with well-known brands.
Through exclusive licensing agreements MightyVolt(TM) will use this cross brand association to leverage battery market share. John Simmonds, Chairman of Pivotal self-Service Technologies explained 'MightyVolt(TM) was created to capitalize on the recognition associated with the licenses and will be timed for release during the height of the license's popularity.'Mr. Simmonds also added, 'that we hope that the products will stand out and be seen as valuable collectibles.'
About Collectible Concepts Group (CCGI)
CCGI is renowned for developing and marketing collectible merchandise, primarily in the entertainment, music and sports markets. CCGI's products are well known both for quality and authenticity. The company utilizes regional and national sales organizations, as well as direct sales methods, to promote its products. The company develops a broad range of collectibles, based upon its ownership and marketing agreements with affiliate companies. The Company's license affiliations have included the Austin Powers movies, Planet of the Apes 2001, Farscape, the Terminator Movies, Marvel's X-MEN and Spider-Man, Mini-V - Verne Troyer, and Marvel Universe.
About Pivotal Self-Service Technologies
Pivotal Self-Service Technologies Inc., through its operating subsidiaries, Prime Wireless Inc. and Prime Battery Products Limited is a distributor and sales representative of high quality electronic products and consumer related products. Visit Prime Battery today at www.primebatteryproducts.com.
CCGI - News out ... !!
NEW YORK, Jun 3, 2003 /PRNewswire-FirstCall via COMTEX/ --
Pivotal Self-Service Technologies, Inc. (OTCBB: PVSS) announced today that Prime Battery Products, a wholly owned subsidiary of PVSS, and Collectible Concepts Group (CCGI) have established and created MightyVolt(TM).
MightyVolt(TM) is a joint venture that was developed by the two companies for the purpose of engaging in the business of marketing batteries and related products that include the display of licensed logos, images, and brand names. The batteries being used for the joint venture are fully tested and compare very favorably with well-known brands.
Through exclusive licensing agreements MightyVolt(TM) will use this cross brand association to leverage battery market share. John Simmonds, Chairman of Pivotal self-Service Technologies explained 'MightyVolt(TM) was created to capitalize on the recognition associated with the licenses and will be timed for release during the height of the license's popularity.'Mr. Simmonds also added, 'that we hope that the products will stand out and be seen as valuable collectibles.'
About Collectible Concepts Group (CCGI)
CCGI is renowned for developing and marketing collectible merchandise, primarily in the entertainment, music and sports markets. CCGI's products are well known both for quality and authenticity. The company utilizes regional and national sales organizations, as well as direct sales methods, to promote its products. The company develops a broad range of collectibles, based upon its ownership and marketing agreements with affiliate companies. The Company's license affiliations have included the Austin Powers movies, Planet of the Apes 2001, Farscape, the Terminator Movies, Marvel's X-MEN and Spider-Man, Mini-V - Verne Troyer, and Marvel Universe.
About Pivotal Self-Service Technologies
Pivotal Self-Service Technologies Inc., through its operating subsidiaries, Prime Wireless Inc. and Prime Battery Products Limited is a distributor and sales representative of high quality electronic products and consumer related products. Visit Prime Battery today at www.primebatteryproducts.com.
Hank Jr... Country state of mind ....
http://tinyurl.com/db2k
Billy Dean .. If it hadn't been you ...
http://tinyurl.com/db10
Waylon & Willie ... Just to satisfy you ...!!
http://tinyurl.com/dax4
Ann Richards, (loser from texas) complaining abo. high gas prices
''Down here in Texas, any women wanting to 'run-over-their-husbands' have to
...................... CARPOOL .... !!
Waylon, Willie, & Hank Jr .....
http://tinyurl.com/dau4
Waylon ....
http://tinyurl.com/dasu
Barry White ....
http://tinyurl.com/d7d2
funny (w/4 letter words) ....
http://tinyurl.com/dacn
What's the opinion of MOST-HERE >
abo. the subject of Media-owned channels(think that's the way they described it) having TOO-much control .... I'm not-UP on this, (as ya can tell)..
All opin's r welcome & thanx ....!
ZZTop .... She's got Legs ....
http://tinyurl.com/d7c4
K² ......... It's wise, (fast on your feet) thinkers like you, that keep em-flashers incheck ... THAT was NOT the result they were seeking ... Well done ...
Sogoodhearingfromyaagaindontwaittoolongnexttimeiwasholdingmybreathandwasblueintheface...... !!
Very Nice site, on test-page, Drumr ... !!
Ya got it, Buddy ... Gimme a lil' time ... !!
Tnx. Onebgg, that gif was a gift ... tee, hee .. !!
Looks like th-Drumr is onto sumpin thar ... !!
Very good, AK ...
http://tinyurl.com/d55v
BIG 10-04, sarals ....
Some Great Truths About Life
1) Raising teenagers is like nailing Jell-O to a tree.
2) Wrinkles don't hurt.
3) Families are like fudge mostly sweet, with a few nuts.
4) Today's mighty oak is just yesterday's nut that held its ground.
5) Laughing is good exercise. It's like jogging on the inside.
6) Middle age is when you choose your cereal for the fiber, not the toy.
~~~~~~~~~~~~~~~~~~~~~~~
I have found inner peace;
here's how you can, too.
I read an article that said the way to achieve inner peace is to finish everything you start.
I finished
two bags of potato chips,
a chocolate pie,
a bottle of wine and
a small box of chocolate candy.
....................... I feel better already.!!
Eric Rudolph (Olympic Bomber) 'just may' be in custody .. !!
Eric Rudolph (Olympic Bomber) 'just may' be in custody ... !!
I take-it that you were able to hear AK's audio ...
I couldn't, got all static ....
Bet it's my webtv .... !!
Since I don't have you .....
http://tinyurl.com/clb3
When will I see you again .....
http://tinyurl.com/cld3
At Last, by Etta .... Scroll to bottom,click & sing along .... !!
http://tinyurl.com/b764
Boot Skootin .... !!
http://tinyurl.com/ckhf