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I think Amarin will get a trail.
my phone died, just before Amarin wrapped up.
Judge Hall was very fair, she gave Amarin a lot of time.
Amarin must be given a change to let Dr Bhatt explain the difference in indications. Laywers are lawyers, they can repeat science but dont understand it. (Same applies to Judges)
Amarin lawyer cant pronounce hypertriglyceridemia! WTF!
Amarin lawyer apologizes to Judge because his phone rings wtf! Turn your phone off!
I thought the delaware case hearing had been pushed out a week? Is it still going ahead today?
Thanks for script Raf - the cat and mouse continues
I think tomorrow will bring some positive news. Karim knows how we feel, we need to give him a chance to do something to restore the share price. Good luck to All.
Elan and Amarin. This is playing out like Kelly Martins departure from Amarin. The long time leader leaves 6 months before a BO. In Elan's case it was Tysabri. In Amarin the deal will be , imo, the following:
1. 50:50 partnership on Vazkepa/Vascepa with a European BP.
2. The outcome of the US legal cases will decide if the BP takes 100% or not.
We will get 25 dollars for 50:50 and an extra 10 dollars per share for the 100%
For those familiar with Lars this is his playbook!
Vazkepa in the USA would only be available for the Cardio indication. There is no generic approved for that.
Vascepa and Generic Vacepa for the greater than 500 7% population.
AMARIN 06-04-21 -FAQ - VAZKEPA is a registered trademark in Europe and other countries and regions and is pending registration[color=red][/color] in the United States.
Could this mean that if AMRN lose the legal challenges they will;
Leave Vascepa for the 7% greater than 500 trig in the USA
Bring "Vazkepa" to the USA for the 93% less than 500 and for Cardio.
Vazkepa is for 100% less than 500 and for Cardio in EU.
So any generic can go after Vascepa to their hearts content ( ) but cant you couldnt substitute generic vascepa for Vazkepa in the USA and definitely not EU.
Thoughts?!!
Thanks Rob777 - great finds
Nature Article - another link to Vascepa's coming world dominance
https://www.nature.com/articles/s41598-021-86747-5
We just need to be patient!
Lemmiwinks i saw the Saw Doctors for NYE in 1991 in Dublin. They were and are still a great night out. Happy Saint Patrick's day to all in the USA from all in the Olde Country. God bless our long lasting friendship and long may it continue. Our day with Amarin will come. Go n-éiri an bothar leat.
Very interesting article - Vascepa - the cure for noise!!
https://www.bbc.com/future/article/20210315-why-noise-pollution-is-bad-for-your-heart
Seminal week for Amarin coming up. I just hope we dont have game changing news on St Patrick's day when stockbrokers are closed in Ireland.
Let me indulge in a little predictions:
1. SC accept the case rehearing - big jump in AMRN share price
2. Stroke data
3. EU Approval - big jump in AMRN share price
4. Rule 60
End the week at 14-20.
Mad? or inspired?
Great work Rafunrafun from Dublin, Ireland Is there any way to see this in Europe - the link is blocked.
Teva V GSK - Surely this is what we should now be discussing. Share price went up expecting one outcome and has retreated because this didnt happen.
never listened to Spanish this intently. Get to the point Dr please.
Can Dr Bhatt speak Spanish?
Jasbg - Link to last nights call https://livestream.com/debakey/cvdprevention020321 not sure if recording available but worth a try
Last nights Bhatt, Millar, Bhudoff call update
Bhatt was clinical - world leading.
Bhudoff - fantastic if frustrated that he has to explain this miracle drug to Cardio audience again.
Millar - weakest link imho. Mentioning milkshakes to get your TG over 150 - sounds amateurish.
If you can get you TG raised with a milkshake surely you can get them over 500 and get the generic???
Big Push on to get the Share price up - I think a buyout at 35 is coming but they need the shareprice to be 15+ before this.
Teva v GSK enbanc decision - any updates on this please
Rule 60 second suggestion - could we not pay the experts in shares.
Currently 7k raised on gofundme. If we raise 13k that is 2000 shares at todays prices.
If they experts contribute to winning the case the share price could by $40 or more which would make those 2k share worth north of 80k
Rule 60 Fundraising suggestion.
The bulk of the money is needed for the following:
We are seeking your help in raising funds to hire 2 M.D. PhDs to review statistical data and write a professional report; this level of professional witness bills ~$500+/hr.
Could someone, maybe on this board, approach Dr Bhatt's team and he must have someone who could do this statistical data analysis (if it hasnt been done by someone already). I cant imagine it should cost this amount of money if Dr Bhatt is helping out.
Rafunrafun - the cute interaction (15 Jan twitter) is one i'll frame when Amarin and Vascepa is the front line defense against global respiratory viruses as well as cardio indications
John Nelson - latest post mentions Vascepa - great read
Director at California Cardiovascular Institute
https://www.linkedin.com/pulse/remnant-cholesterolnot-ldl-cholesterolis-associated-john/?trackingId=M8oPD7DAhdWT6L2xtCPxPw%3D%3D
This is the title of the study just published in JACC vol 76(No.23) :2712-24) authored by Dr.Olga Castner et al.There are several ,very important comments made in this manuscript that I fully endorse. I have recommended treatment of elevated remnant lipoprotein cholesterol(remnant-C) in high risk patients for many years.
Study Design: "The PREDIMED study was a multi-center,randomized clinical trial that tested the efficacy of MedDiets enriched with extra-virgin olive oil or mixed nuts against a control diet diet for the primary prevention of CVD in older patients at high CV risk'
Remnant lipoprotein cholesterol (Remnant-C) was simply measured as Total cholesterol minus LDL-c minus HDL-c.(As us lipidologists know this converts to Triglycerides/5)
In multivariable -adjusted analysis,triglycerides(HR):1.04;95%CI:1.02 to 1.06,per 10mg/dl(0.11mmol/l);p<0.001,non-HDL-C(HR):1.05;95% CI:1.01 to 1.10,per 10mg/dl(0.26mmol/l);p=0.026) and remnant-C(HR:1.21;95% CI: 1.10 to 1.33 per 10mg/dl(0.26mmol/l);p<0.001), but not LDL-C or HDL-C were associated with MACEs.
"Remnant-c was the major cholesterol fraction contributor to MACEs in our cohort of participants at high cardiovascular risk but who had no previous CVD;these subjects had moderately elevated triglyceride concentrations and a high frequency of statin treatment"
"Participants with Remnant-c levels >/= 30mg/dl (75th percentile of the cohort)had a higher risk of MACEs,regardless of whether LDL-c was at optimal levels(</=100mg/dl;2.59mmole/l)."
"From the present data,it could be inferred that treatment of residual risk,measured as triglycerides or remnant-C,was probably more beneficial than further reducing LDL-c in high-risk subjects in primary prevention not eligible for statin treatment or already treated with moderate- or high dose statins"
Take a look at Figure 4 and the LDL-c and remnant-C Kaplan-Meier curves.....Amazing!!!
Mt Hat is off to Dr.Olga Castaner and colleagues for a such a wonderful and extremely clinically relevant paper
I would like to add that the FDA approved ,prescription icosapent ethyl plays a key role in reducing CV events in patients with Triglycerides >/=150mg/dl with CVD or DM and 2 or more additional risk factors for CVD.
For those who want to read more about "The Role of Remnant Lipoproteins in Atherogenesis" I refer you to the paper authored by myself and Paul N. Hopkins,MD,MSPH published in the National Lipid Associations Lipid Spin Volume 11(2) Spring Issue 2013,pages12-15,38-39.
flyfishingstocks - I love your posts
JP call was ok, nothing extraordinary. Did not hear JT mention the hot of the press patent from 05th Jan. The call presenter seemed wasted.
Love your posts FFS, your last one has caused my wife to wet her panties
End of year price - $18
Why - Because that is the price GS will deal with.
In my heart of hearts I want 32
No Debt - For sale sign has gone up. No Guidance - Deal must nearly be done.
I hope so BB and that would make sense. And yet MTNB shares rocket - maybe just speculators.
AMARIN and her investors need reward for what our science she has provided.
MTNB - Are we worried about the enhanceIT trail?
1. AMRN have hacked off the FDA
2. Seems strange that a drug still in P2 can do a head to head against an approved drug Vascepa?
3. Are we being set up to fail one last time with AMRN?
From my understanding MTNB'S drug is a mix of epa and dha - is that correct? If that is right it should fail.
Thanks and Happy New Year to All.
We're on the EMA agenda in December
search : icosapent
https://www.ema.europa.eu/en/documents/agenda/agenda-chmp-agenda-7-10-december-2020-meeting_en.pdf
Where is Jesselivemore gone? i used to like his posts.
In 2022 JPM forecast 600mn to 200mn equals Marine infringement if true. Genterics cant explain taking 60% of the vascepa market if greater than 500ml equals 10%.
Bidmark, freudian slip, Congressman Neal. Very sunny in Dublin today, I might have stayed out too long.
I am still going to send the Congressman a letter and appreciate any constructive templates.
Best Wishes