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Not able to find a partner for B-ABSSSI and B-OM after all these years is a big red flag.
competitive treatments for ABSSSI
OM is one of the cheapest trials we could run. Literally a mouth wash. Swish and spit. Also it's phase 3 which will bring lots of interest.
also announced that they are friggin clueless in developing the oral pill
Well, them MMs ain't good at following directions, that's fursure
MMs trying to demoralize flippers into selling by taking out stop loss orders.
Famous last words of the guy at that rummage sale, who passed by the Piccoso I grabbed up and bought for pennies on the G-notes.
If the data fails in Covid, you are neither an antiviral company nor a company with an iota of credibility.
Another gem of a timeline and delays and management
Coke heads and shoplifters prob running this one
Maybe I'm out to lunch here but it sounds like a glitch not too difficult to over come?
Development of a delayed release oral formulation has been in progress, with development work expanding into immediate release formulations due to unexpected findings encountered. Such findings appear due to the inherent physiochemical properties of the compound, and those of polymers used to achieve delayed release. An immediate release, multi-particulate capsule formulation has been developed and a ‘research and development’ batch has progressed to stability testing at the manufacturing vendor. Further work is ongoing, in preparation for manufacture of clinical trial supplies
All I can say is it’s almost “next year”…
I'm down quite a lot here but reminds me of a company using funds to pay for research and line management pockets.
Thanks Mods/Stickied Posters for your DD.
I'm a IPIX newb.
I didn't notice the stickied posts last week - great stuff - so started frantically doing my own DD.
I nearly shit myself :).
Brilacidin = Xerox Alto ?
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H/t attilathehunt for the well-placed breadcrumb riddle at the bottom of your post on another board. I goopled it, followed you here and after some hurried DD last week nearly shit myself.
Try diapers.
my thought was if you don't even try at these things how bad are things going behind the scenes? Totally unprofessional and out right embarrassing.
As far as MRKR, only got two choices, sell at a big loss, or hold on and hope.
But there are a better options.
Complete NONSENSE : Ivermectin ... "anecdotal evidence" is strong in support of its use"
-Ma Gramma used it to deworm herself
Yeah, good luck with that.
I'll take SCIENCE over "anecdotal evidence" some idiots pulled out of their wretched Rectum.
Have you looked at the ACTUAL RESEARCH ???
Go back and look at the individual studies this clown show paper used and keep an eye on how many turn out to be GARBAGE.
" 20 randomized clinical trials (RCTs) have tracked such inpatient and outpatient treatments. Six of seven meta-analyses of IVM treatment RCTs reporting in 2021 found notable reductions in COVID-19 fatalities, "
https://pubmed.ncbi.nlm.nih.gov/34466270/
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Like the FRAUDULANT PAPERS the liar used to make these nonsense claims that
Ivermectin can treat COVID ???
How about those scientist who shit themselves when they found their data used was compromised- "someone" copied and pasted the same nonsense over and over in the raw data they used . . . well, there goes their reputation.
Or how about the "research" where Upon Further Review - the people "treated group"ALL had good baselines to begin with - e.g. high blood O2 _____MEANWHILE the the DEAD Placebo Group"" all were At Deaths Door minutes before chosen to be the placebo. I.E. the "researchers" wereVery Selective about who they chose to sort of, ah, well should we say SLANT THE RESULTS . . .
Oh, you mean the "anaecdotal data" <-- Oh I'm Sorry, I thought you were talking about RESEARCH fraud . . .
Go back to the Rabbit Holes where you heard the "anecdotal data" and maybe start asking some questions . . .
"dO yOuR REseaRch !!! DUH!
WHat is Brilaciden ??? And Who GAFF?
It is a Patented "mimic" (synthetic/man made) form of:
- Human/Host Defense Proteins
- Defensins
- Antimicrobial Peptides
https://www.frontiersin.org/files/Articles/501450/fmicb-10-02866-HTML/image_m/fmicb-10-02866-g001.jpg" rel="nofollow" target="_blank" >https://www.frontiersin.org/files/Articles/501450/fmicb-10-02866-HTML/image_m/fmicb-10-02866-g001.jpg[tag]What do the DO ??
- What DON'T they do ???[/tag]
How do they kill -they don't just "poke holes" bacteria and viruses
-Antibacterial Peptides
--Anticancer Peptides
---Antiparasitic Peptides
----Antiviral Peptides
-----Antifungal Peptides
Membrane Targeting Mechanism
- The Toroidal Pore Model- wormhole model = AMPs vertically embedded in the cell membrane accumulate and then bend to form a ring hole
- Barrel-Stave Model - penetrate thecell membrane nd form channels that result in the cytoplasmic outflow
- Carpet-Like Model- cover the membrane surface that similar to a carpet and destroy the cell membrane
Non-membrane Targeting Mechanism
- Inhibition of Cell Division
- Inhibition of Protease Activity
- Inhibition of DNA/RNA synthesis
-Inhibition of Protein Biosynthesis
----------------------------------------------------
A) Defensins and Other Antimicrobial Peptides and Proteins
1)Endogenous Antimicrobial Peptides are widely distributed (plants,animals,invertebrates = Ancient Immune System)
2)Most are amphiphilic, polycationic molecules with an a-helical, cystine-stabilized ß-sheet, or proline-rich structure.
3)They represent elements of a robust, ancestral animal immune system that predates the advent of lymphocytes and immunoglobulins
---------------------------------------------------
Antimicrobial Peptides (AMP): Classification, Design, Application and Research Progress in Multiple Fields
1) These peptides vary from 10 to 150 amino acids with a net charge between -3 and +20 and a hydrophobic content below 60%.
2)The sequence diversity enables human AMPs to adopt various 3D structures and to attack pathogens by different mechanisms.
3)The universality of AMPs is evidenced by the identification of these molecules in a variety of organisms: bacteria (i.e., bacteriocins), protozoa, fungi, plants, and animals.
4) Key components of innate immunity, human host defense
5) In addition, AMPs can possess other biological functions such as apoptosis, wound healing, and immune modulation. T
6)Over 100 such peptides have been identified from a variety of tissues and epithelial surfaces, including skin, eyes, ears, mouths, gut, immune, nervous and urinary systems.
---------------------------------------------------
DEFENSINS
1) Defensins are members of a large family of cationic antimicrobial peptides that form an essential element of innate immunity.
2) They are key effector molecules in host defense against infection due to their broad-spectrum antimicrobial activity.
3) Defensins are small, cationic peptides that contribute to the antimicrobial activity of phagocytes, the skin, and the mucosa (including that of the lung).
4)Neutrophils and epithelial cells are the main cellular sources of these peptides, but monocytes, macrophages, dendritic cells, and lymphocytes also produce defensins.
NEXT QUESTION: Brilacidin- Antibotic Resistant Bacteria's WORST Nightmares~
Comparative Mechanistic Studies of Brilacidin, Daptomycin, and the Antimicrobial Peptide LL16
Brilacidin has shown great efficacy in phase II clinical trials against acute Staphylococcus aureus skin and skin structure infections, comparable to that of the lipopeptidic drug daptomycin, which is currently used clinically to treat drug-resistant staph infections (20).
Brilacidin also has potent broad-spectrum activity in vitro against several other Gram-positive and Gram-negative pathogenic bacteria, including several multidrug-resistant strains (16, 21).
NEXT QUESTION - Beyond COVID-omg, the sky is the limit.
Do Not Be Short Sighted - Brilacidin is a Patented "Mimic" of natural
"defensin"or "anitmicrobial peptiedes"
1) Biotech and the investment community has been OVERLOOKING these "primitive" immune molecules because they get a hard on for "genetically modified" and other EXPENSIVE and HIGH TECH medical approaches.
Fkn bone heads - as FAR as the EYE ORBs can see.
1) AntimicrobialProtiens are some of the EARLIEST forms of Immunity in the Evolution of Life. > They are found in plants and animals
3) Primitive"" Antimicrobial proteins (AMPs) will BLOW THE DOORS off of immune therapies for a large number of diseases.
Clinical Applications of Antimicrobial Peptides (AMPs): Where do we Stand Now?
"AMPs show a wide spectrum of biological activities which include antiviral, antifungal, anti-mitogenic, anticancer, and anti-inflammatory properties. Apart from these prospective therapeutic potentials, the AMPs can act as food preservatives and immune modulators. Therefore, AMPs have the potential to replace conventional drugs and may gain a significant global drug market share.
NEXT QUESTION: COMBINATIONS? + Remdesivir ??? Or the generic OCD med fluvoxamine"???
The next trials will be combinations
Easypeasy with a generic drug: fluvoxamine
OCD drug spotlighted as potential COVID-19 treatment
------------------------------------------------------------------
Brilacidin, a COVID-19 Drug Candidate, Exhibits Potent In Vitro Antiviral Activity Against SARS-CoV-2
Brilacidin’s main mechanism appears to disrupt viral integrity and impact viral entry. Brilacidin and remdesivir exhibit excellent synergistic activity against SARS-CoV-2.
We demonstrate that brilacidin, a synthetic small molecule with peptide-like properties, is capable of exerting potent in vitro antiviral activity against SARS-CoV-2, both as a standalone treatment and in combination with remdesivir, which is currently the only FDA-approved drug for the treatment of COVID-19.
NEXT QUESTION -What BP will be our partner.
Most BP will want to be in on ANYTHING that works against COVID.
Probably
PFIZER ANNOUNCES AGREEMENT WITH GILEAD TO MANUFACTURE REMDESIVIR FOR TREATMENT OF COVID-19
EXACTLY:MoMos and Retailers Panic and cling to goofy conspiracy theories.
The reaction this morning allowed SmartMoney to pick up shares.
Normal retail reacts to news and trades out of fear or lack of knowledge.
Professional traders use the news for trading against retail.
Ignore the Market NOISE
Keep your eye on the prize:
Brilacidin, a COVID-19 Drug Candidate, Exhibits Potent In Vitro Antiviral Activity Against SARS-CoV-2
Brilacidin’s main mechanism appears to disrupt viral integrity and impact viral entry. Brilacidin and remdesivir exhibit excellent synergistic activity against SARS-CoV-2.
We demonstrate that brilacidin, a synthetic small molecule with peptide-like properties, is capable of exerting potent in vitro antiviral activity against SARS-CoV-2, both as a standalone treatment and in combination with remdesivir, which is currently the only FDA-approved drug for the treatment of COVID-19.
No it's not a joke.
ivermectin is THE JOKE
There's an idiot doctor in Wisconsin who was saying the same stupid shit.
DO NOT trust these "renegade" doctors.
My Mentor in grad school and in post doc was an MD.
He cursed the day he decided to MD instead of PhD.
We'd have 8-12 MD (residents and med students) in our lab every year and my Mentor said he had to BREAK THEIR BRAINS to undo the damage done with medical school training.
And then "teach them how to think again."
I wish they included a patient population using Remdesivir
Laboratory-Testing-of-Brilacidin-for-COVID-19-in-Combination-with-Remdesivir-Reduces-Viral-Load-by-Nearly-100-Percent.html
[
Man does not eat Lobster by TA alone.
A move like this was predictable.
YES !!!-->>
We need a gap killer.
It's how you keep the salaries and bonuses going while doing slow motion research for researches sake.
Micro, I just tried to watch the first two - Wainwright and Oppenheimer.
---------------------------------------
PLEASE MRKR MGMT - D O N O T D O A N Y M O R E conferences if you are just going to half-ass it like you did with these two.
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Wainwright - why have the CFO present clinical data? Actually, he didn't present anything, he read note cards
Why put up slides like "Future Milestones" and all but one of them be things "completed" - and then say virtually nothing concrete about the one not yet completed?
WHY put up a slide on pancreatic full of sentences and then say, "I don't have to tell you about this" and say parts of two sentences seemingly at random and move on ...
Seriously, WHAT IS WRONG WITH YOU IDIOTS?!?!?
---------------------------------------------------
Oppenheimer - a middle school level, cheap podcast babble-fest,
NO DATA TO LOOK AT, babble all over the place. WHY NO SLIDES???
Do you idiots REALLY THINK WE just want to watch her as she looks around the big cavernous room, fidgeting with her hair and babble barely coherently ("Ah, um, and ah, um jargon-jargon <audio cuts out< but it looks really good, <audio cuts out> and, and ah, um and .audio cuts out< ")
NEXT TIME PUT ON GRAMPA SIMPSON TO TELL US ABOUT THE ONIONS they wore on their belts because that was the style back then.
-----------------------------------------------------
Honestly, what in hades was the point of doing this to us?
Do they HATE SHAREHOLDERS?
DO THEY WANT TO SCARE AWAY POTENTIAL INVESTORS???
I doubt a single person who tuned in to either of those MUMBEFESTS stayed longer than half way through. Anyone who did was probably found curled up on the floor in the fetal position whimpering and mumbling, "there's no place like home - make it stop, PLEASE make it stop."
I am STUNNED that the share price did not collapse below a dollar after both of those amateurish, go-through-the-motions "conferences."
I've seen better presentations at weekly lab meetings by undergrads presenting stuff on their little projects. I-am-not-exaggerating.
PLEASE STOP DOING CONFERENCES.
PLEASE HIRE COMPETENT PEOPLE FOR IR.
PETER _ ARE YOU THERE???___ ARE YOU IN A COMA???
Where is the BOD? UNREAL.
Ok, that's my 2 cents worth.
For all of you who have stuck around all these years it about to crater big time if this on gong trial doesn’t show significant results to get an approval from the FDA. Even if it does I don’t see this stock ever getting back to my break even point of $5.25.
COUNT Yer Blessins MRKR LOOOOOONGS...................
MRKR is going to see Higher Highs, and Higher LOWS for the rest of the time us poor Hapless stupid hairless apes known as Homo sap-saps have left on this fizzling out little orb.
REMEMER---KIVA KIVA KIVA the living poop out of the money changers - fuggem if they can't take looking at themselves in the mirror, the sad jokes.
>OUT< I think ... who knows anymore ........... by the way, do not feel guilty or whatever as the feces flies, no one in anyverse and certainly not our pathetic little 3dt ever had any control -------
"added the dipper $$$$$"
good job Skipper, gilligan here <out> back to the PAAAAAAAAAAAAAAArty (aaAAAAAll By myyyyselfEelf, &&&&& I don't mind at all (lazlo bane)
.
.
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edit "sentimental tears ......... Seven years ago,
I said good-bye to my own sanity; when I bought TPIV omg, omg omg lmao all the fkn way to the seven banks I'll need to carry the load
micro - seriously, ffs, I mean if you really need the cash - unless I missed something????????? just ride the storm out, we b digging out of the fallout soon enough................ after allllllll us patients beeeeinnnnnnng soooooooooooo having so much patience........... why is mrkr climbing these days ......lmfao......... the science, b real............ our therapy will be combined with IBRX (NK moerger) whether our CEOs have the brains to partner or not.............. the clinicians will after both our approvals..................... Just had to stop in and see why it's raining again, in case newz was missed by me........ the market giveth, and the market taketh away, but goodgodalmighty, and goodgollymis molly <> OUT<> agin&agin&agin we go round in circles
.
.
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OOPS - sorry MajorTom, take a protien pill and put your helmet on. you were responding to Micro. mybad :)
out agin
Read this before the one I just posted so you don't go into it too depressed. I tried to edit last minute to put the following:
Who knows, maybe MRKR and NK someday be sitting in a tree, k-i-s-s-i-n-g-ing away, looking down on the peasantry among the CAR-T riffraff crying in their soup below as they gnash their teeth etc. . .
Maybe a clinical therapy partnership in early intervention using complementary cellular immunotherapy therapies that are safe, with combined costs that are Still inexpensive, and that are both highly effective individually - and maybe greater than the sum of their parts together, maybe even greater than chocolate and peanut butter spread on sliced fkn bread pray tell ?!?!?!
(gotta lead into the rest with a HYPE Train . . .)
---------------------
Good night to all and may 2021 begin MRKR's Phoenix like rise to form a Palidromic chart the next decade.
>Out<
NantKwest, NK: Everyone's Major competition for Pancreatic Cancer and a LOT of other cancers
Disclosure Upfront - Long NK - But I have not and am not selling a single share of MRKR. My break even is now $3.39 after an impossible coincidence at the last minute allowed me the opportunity to make one last large buy at $1.65 Jan 5. I've known about NK since last year and I think their upside is ultimately greater than MRKR for a number of reasons. Still, on Jan 5 I chose MRKR bc I think MRKR could possibly do what NK has done in the past 14 months (up from ~$1.24 to $30, >2000%), over the next 14 months.
----------
NK's "world's first off-the-shelf genetically engineered natural killer cell platform" is both very safe and inexpensive like MRKR. But so far it looks more effective for Pancreatic and they are starting to move into blood cancers.
Their platform consists of 3 NK cell line products that locate the tumor in distinct ways, and then kill targeted tumor cells using granzymes and perforin.
1. haNK - use antibody receptors that locate tumor cells coated with anti-tumor monoclonal antibodies.
2. taNK - use NK cells genetically engineered to carry CARs on NK cells.
3. t-haNK - combination of the taNK and haNK cell lines using anti-tumor monoclonal antibodies.
["Our haNK®, taNK®, and t-haNK™](https://nantkwest.com/about/) platforms have been designed to address "certain limitations of T-cell therapies including the reduction of risk of serious “cytokine storms.”
As an “off-the-shelf” therapy, NantKwest’s NK cells do not rely on a patient’s own often compromised immune system.
In Phase 1 clinical trials in patients with late stage cancer, Nantkwest’s NK cells have been administered as an investigational outpatient infusion therapy without any reported severe side effects to date, even at doses of 10 billion cells.
--------------------
[NantKwest, ImmunityBio Announce Positive Interim Data on Survival Rates in Metastatic Pancreatic Cancer Trials](https://nantkwest.com/nantkwest-immunitybio-announce-positive-interim-data-on-survival-rates-in-metastatic-pancreatic-cancer-trials/)
Jan 13, 2021 | Press Releases
Pivotal QUILT 88 trial based on combination immunotherapy of “Cancer Moonshot” strategy; early indications of increased survival rate for pancreatic cancer patients with no other approved treatment options
- In initial Cancer Moonshot QUILT trials of haNK and avelumab (PD-L1 checkpoint inhibitor) completed in 2019, median overall survival rate more than doubled compared to historical controls (eight months versus three months)
- A complete remission was achieved when replacing haNK and PD-L1 checkpoint inhibitor avelumab with PD-L1 t-haNK and four out of five patients are alive 8-16 months since beginning treatment on these expanded protocols
- Based on this encouraging early data, a single-arm Phase 2 study (QUILT 88, Cohort C) was initiated in October 2020, for which the primary endpoint is overall survival and 15 out of 18 (83%) of patients enrolled with second-line or greater pancreatic cancer remain alive to date.
- Randomized trials in first- and second-line pancreatic cancer are actively recruiting at three sites with more than 50 patients enrolled or being evaluated in QUILT 88 to date
I tink dare MUST BE MAnippleation going on here.
Shorts and market makers manippling away setting folks up for a short attack???
I bet a lot of manippling watchers here have a lot to say about the manippling going on here.
I'd LOVE to hear from the manippler squad here . . .
What do you do when a mod deletes posts critical of his posts - that are on topic, and do not violate any rules?
Here he even taunts by responding to my post, and then deleting my post.
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=160529538
Here the post, one in a series, that he deleted.
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Re. Mfg Facility. They have multiple dedicated rooms for sterile cell culture. Different types of rooms for both incubation rooms and sterile lab bench work for manipulating cells. And both of those are either dedicated for patient's Multi- TAA T cell prep and supply, and for general research - and for specialized research e.g containment if using pathogens.
=============================================
Go ahead Mod Weasel, delete away - what is this, #5??? And now you delete Micro's post too?
----------------------
Oh yea, ya'll check out the mods for this board.
They keep deleting this post - I guess Censorship is a thing here now. Mayby just posts calling out short-scams where they pretend to be longs, and then harass and run of quality posters like Phantom
So yea Gittin-Stupid and MD-I-AM NOT, the two stupidest twerps on the board with the biggest mouths, ran off the ONLY poster -phanotm -who knows his ass from a hole in the ground.
They are Poster Children for the Dunning-Kruger Effect.
https://medium.com/discourse/the-dunning-kruger-effect-explains-why-society-is-so-screwed-up-1432aca90aa8
Now go ahead weasels, delete this post again.
edit - funny, the reason I quit this board is the random deletion of my posts.
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https://investorshub.advfn.com/boards/RequestReview.asp?msg_id=160527233
Weeeeell, ok then.
I'm long and I am treating my shares like warrants exercisable at some date so far into the future I do not bother paying attention to it for now.
Good Luck.
P.S. Feed your squirrels gotta-git, they might leave your birdfeeder alone.
Floridajim, you b jammin?
Man that looks like a lot of technical gibberish so, sorry, I'm not wading through it.
The point was there are are a lot of reasons a clinical study could be extended.
Maybe the results are impressive so they want to include longer term data for survival rates, or maybe PI was out of commission for a year with debilitating constipation. WTF knows?
Alos, that's a Mayo trial, so yeah, hire a Carnac The Great if we want clue about what is going on up their in the land of the Lutefish-eating Mudducks.
[for the (permanent) record: Pack 4-0, Bears 3-1, Lions 1-3 , Queens 1-3]