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Wednesday, November 10, 2021 9:55:42 AM
Development of a delayed release oral formulation has been in progress, with development work expanding into immediate release formulations due to unexpected findings encountered. Such findings appear due to the inherent physiochemical properties of the compound, and those of polymers used to achieve delayed release. An immediate release, multi-particulate capsule formulation has been developed and a ‘research and development’ batch has progressed to stability testing at the manufacturing vendor. Further work is ongoing, in preparation for manufacture of clinical trial supplies
Scientist#1: "Ah, guys, wait a sec . . . "inherent physiochemical properties of the compound, and those of polymers used to achieve delayed release."
Scientist #2: "Awe, shit, gob dammit, so B is getting gooped up with the delayed release polymers? And so B doesn't work when it gets gooped up with the delayed release polymer?
Sci #1, "Ah, yeah, I guess so, maybe???
Scientiest #3 (playing Pong in the corner of the lab): Well, try double-coated capsules maybe? Like maybe: Coat 1= delayed release polymer capsule to get it through the small intestine, and coat 2 = immediate release polymer capsule that dissolves after the goopy delayed release polymer is out of the way? I mean, it might take a little dickin' around to get the details just right but, no biggie really.
Scientist #4: Make it so number 1.
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