Register for free to join our community of investors and share your ideas. You will also get access to streaming quotes, interactive charts, trades, portfolio, live options flow and more tools.
Register for free to join our community of investors and share your ideas. You will also get access to streaming quotes, interactive charts, trades, portfolio, live options flow and more tools.
Miss Australia,
Thank you for the compliment and your continued valuable input.
As of today, the death sentence of Alzheimers is alleviated by nothing.
The only fear regarding Anavex is not that it might kill you, but that it might cause agony and pain which could have been avoided.
So my point is at the ages we are talking about and the sentence of death that is Alzheimers..We should be able to allow Patients and their Families to choose to take more risk than perhaps we might otherwise.
If someone is dying of Alzheimers (Severe) and their family is OK with giving them Anavex..I feel like we are being cruel by NOT giving it to them..
Everyone who wants Anavex should be allowed access if the drug is affordable and continues to not cause pain..
IMO..
Doesn't mean we can not have different opinions..
But I think you will find ..the Public Response to Access will mirror
my forward thinking posts..and SOON, very SOON you will have a CRY for A2-73 that will not be silenced..only answered..
Another New Story..soon to be the Non-Stop News Cycle
the Sigma 1 Ligand which is called the "Chaperone" allows CNS Neurons to perform properly...Listen to Dr. McFarlane's Radio Interview..he outlines the Proteins..Tau and Amyloid..from what I understand it is the misfolding of these proteins that causes buildup..Anavex PREVENTS the Misfolding..and per our recovering AD Patients..Neuronal Cells may be brought back!
the market makers are shorting the tops, walking down the stock to fill the gap and then covering..i believe it is illegal, and some MM have been prosecuted for Short Selling under certain circmumstance..SADLY the MM could be running an ORDERLY Market ..NOT GAPPING up the STOCK to TRY and SKEWER PEOPLE..but what are you gonna do..IT IS EASY MONEY FOR THE CABAL..
So the brain of a Dr. or an engineer or of a lawyer of a bureaucrat..
consumed with knowledge and process is unable to walk through an open door.
trying to simplify it..
Tomorrow you can not remember who your son is or maybe just his name eludes you for a second....
If you take this pill, you can remember..
That guy(gal) over there says maybe in two years we can give you that pill, but until then you deteriorate and rot in an emotional and intellectual hell..
Now that guy(gal) over there..he knows his son's name..
and he figures he will for at least two years. Right?
Humanity is not going to sit well, NOR sit quietly, HUMANITY is not going to sit at all ,,really, KNOWING there is something that WORKS and so far has no bad side effects..
MARK MY WORDS!
ALL the Intellectuals in the WORLD are not going to silence the cries..
so just thinking about human beings in general and all the drugs we take from the day we are born until the day we die..
we take drugs for headaches, to sleep, to wake up
to feel better, to speed up , to slow down. to have babies, to not have babies,,a
and of course there are all the bad, addictive and murderous drugs we take to FEEL BETTER..Herion, ALL Opiates, Oxycotin(?) , marijuana, alchohol, anti-depressants..ALL of which have wicked bad side effects..
than I think of all the wonderful people who are so sick that they can not remember to tell you that they would absolutely TAKE A DRUG THAT STOPS THEIR DISEASE..that doesn't cause WICKED SIDE EFFECTS..and WILL SAVE THEIR LIVES..By the way..just so you know..THAT IS EVERY SINGLE ALZHEIMERS PATIENT is for WHOM WE FIGHT!
I get a little frustrated at the Wicked Irony. All the people who want a placebo, a control..have to wait 5 years to look in a testube ..and then we have to be able to charge an arm and a leg, because we have to be able to sue somebody..
Let's just take A2-73 Black Market,,Make it illegal and give it to the drug cartels to make in SO. America or Afghanistan..WTH..maybe the sick will get it faster..
I really don't understand the wicked slow pace for drugs that don't show
poor side effects and have result when you are dealing with diseases that carry an automatic death sentence( a slow painful, emotionally crippling one at that)..Most AD Patients..don't have a lot of time left regardless of AD, so when we BREACH THE BASTARDS WALL, WHY AREN'T WE STORMING THE BREACH?
I think we should be handing A2-73 out like Candy on Easter Sunday
testing everyone's math:
If ONE equals, extension of trials for two years as demanded by patients and patients playing piano, painting picutres, playing golf..
and ONE equals a overtly lengthy delay in the release of Data..
What does TWO EQUAL?
To me it is only and may be ONLY ONE THING..
The Data is OVERTHETOP, OUTRAGEOUSLY, SANCTIMONIOUSLY, UNBLEIEVABLY
tremendous. Who is gonna believe it? The good Dr. is just preparing the way not to make the most MONEY out of the Test Data, but to make the most HEADWAY for SAVING PEOPLE'S LIVES..
If Missling's number one goal is to make people better, he will have adifficult time partnering or selling to BP. He would rather pave a trail with Big Government who mostly pay for sick indigent elderly. BP has so many agendas..including their own drugs which may be rendered VALUELESS by A2-73 and A5-71. The world is wickedly competitive..just read the YMB..
no need for PR. No need for hype. Anavex breaks the Golden Rule
with the "We can make you better Rule". We are Blessed. the path is already being beaten to the Anavex door. We are in a fight, but it is a fight we will not lose. God loves a good song, and a beautiful painting!
Jack Handy thought for the day:
Anavex's Piano Player and Artist, I bleieve, were both YEARS into the darkness of Alzheimers and YET, A2-73, not only ceased the decay but revived, restored, cured their mental trials and their being's love of life. regardless of how long this War takes, WE WILL BE ABLE TO GO BACK YEARS and HELP PEOPLE! Should not we be just giving this drug to Severe patients..NOW?
We are at War. It is Anavex against BP. If you have not figured it out yet, it is because you are a little slow on the uptick. We have a curative, well tolerated treatment for Alzheimers and yet, our company is ATTACKED, not praised. Why? Because Big Pharma can not afford to allow Anavex to move forward. I understand and you should as well, because even though THEY are at War with US, WE WILL WIN! But ladies and gentlemen, in order for Anavex to WIN, WE must begin to fight. I know there are Shorts and Traders on this Board that are decent people, please consider the cost of your profit, as it DELAYS this curative drug to market. It does. For you believers in Anavex the Drug, The Company, The Leadership, it is time for us to say "CURE", "CURATIVE" and begin the "WAVE THAT NEVER ENDS" for A2-73. Shout it high, Shout it Low, but for goodness sake's demand that A2-73 become Available to our friends and family that are sick. Big Pharma is more concerned about their profit than helping AD Patients, that is painfully clear. We have the Game Changer Weapon, and it is GOOD, do NOT BE AFRAID to USE IT! Anavex is CURING ALZHEIMERS in SOME PATIENTS! Let's get it in MORE!
Yahoo just picked up Renauer Hit piece..but it's so poorly written as a Distort Piece it might drive the stock higher..hilarious..God is Good!
respnse to cory de shortliar of a Fool of You 4 Me:
So you found someone named Dr. Hendrix to say Placebo Effect renders results meaningless? That is an outrageous LIE! The Placebo Effect for Alzheimer's Patients is rendered NON-EXISTANT after 12 Weeks or LESS! To have an EFFECT ..ANY EFFECT after 8 Months is PK-Action-AKA -Curative! I understand a lot of people SHORT STOCKS and MAKE MONEY when they go down..but WHY DO PEOPLE HAVE TO LIE and OBFUSCATE GREAT NEWS and HOPE in order to make a dollar. It is sick.
Placebo Effect for AD is documented that at 12 Weeks almost ALL Placebo Control Patients not ONLY do NOT show Placebo Effect, which at 5Weeks may have been eual to or as stong as Aricept-still very weak- but thier ADCS-ADL numbers revert all the way back to Patient Group that received ZERO Pills. Dr. Hendrix has ZERO credibility, as does this author, who has previously written a hit piece regarding Anavex. Cory has written other postive articles about Alzheimers Drugs and the Market Opportunity that they present..Hmm..here is what Cory said when he was pumping up Biogen after a Phase 1b study!
http://seekingalpha.com/.../2731695-what-biogen-idecs...
They couldn't play the Piano yet or paint ..but Cory was PAINTING QUITE the picture for Biogen! biogen went up $29 BILLION in Market Cap..only to lose it.
Maybe Cory is still paying off that debt by Trashing the renewed Artistry of Cured Alzheimers Paitents with Anavex!
Cory might be slowing down the process of sick people getting mediicine ..the real question is ..Why?,
Here is a 24 wwek study showing at 6 weeks Placebo-Effect and Aricept have same effect but ever after the Placebo Group is GONE!
The efficacy and safety of donepezil as a treatment for patients with mild to moderate Alzheimer's disease (AD) was investigated in a multicenter, double-blind study. Patients were randomly assigned to treatment with placebo (n = 162), 5 mg/d donepezil (n = 154), or 10 mg/d donepezil (n = 157) for 24 weeks followed by a 6-week, single-blind placebo washout. The primary efficacy measures were the cognitive portion of the Alzheimer's Disease Assessment Scale (ADAS-cog) and the Clinician's Interview Based Assessment of Change-Plus (CIBIC plus), with the Mini-Mental State Examination (MMSE), Clinical Dementia Rating Scale-Sum of the Boxes (CDR-SB), and patient rated Quality of Life (QoL) used as secondary measures. Cognitive function, as measured by the ADAS-cog, was significantly improved in the 5- and 10-mg/d donepezil groups as compared with the placebo group at weeks 12, 18, and 24. Clinician's global ratings on the CIBIC plus also improved in both the 5- and 10-mg/d donepezil groups relative to placebo. At the end of the 6-week placebo washout phase, ADAS-cog scores and CIBIC plus ratings were not significantly different for the three groups. Significant treatment benefits were also observed consistently in both the 5- and 10-mg/d groups on the MMSE and the CDR-SB, but there was no consistent effect on the patient-rated QoL. Cholinergic side effects (primarily diarrhea, nausea, and vomiting) were reported more often in the 10-mg/d group than either the 5-mg/d or placebo groups. Side effects were transient and generally mild in severity. These data indicate that donepezil is a well-tolerated drug that improves cognition and global function in patients with mild to moderate AD.
This is repeated Time after Time rendering Placebo Control Groups meaningless for succesful AD Treatments..You only need them if YOUR DRUG is BARELY WORKING!
Anavex is ROCKING OUT the Treatment! Playing the Piano, Painting are PLACEBO EFFECTS at 8 Months?
This is truly a SICK ARTICLE!
so we need a placebo for control group? no we do not. period. it is not complicated. if this were a new disease, or not deadly, or blah blah blah..but we have all the stats we need for the people who don't get medicine to treat Alzheimers..THEY DIE forgetting everything and everyone they love. There ..you have your control group..now give everyone else ANAVEX..It is not complicated. It is very scientifically factual..
sometimes we forget to be human beings first..
the good Dr knew these stories were on the way..Probably after 2 year extension they gave patients the green light to spread the word..The good Dr understands the shorts PREY on retail hopefuls that do not understand the treachery and lies of Market makers, Short Sellers, Traders, Seeking Alpha, the Street ..et al..WHO COULD UNDERSTAND a CABAL against Alzheimer's treatment? The good Dr. has a plan and you can not sell the news when it never stops..The Anavex news cycle just became 24/7..and everyday , the next day might bring bigger news..short that Big Daddy and your Cabal..
maple syrup, vicks cough(day) and Coconut flour..
now who is making the pancake for that? the good Dr. building a beautifully complicated Puzzle..it is fun to watch the pieces being moved around..
tomoroow I listen to classical Music, buy some art and maybe play some golf! God Bless!
how many times must i say it..they have done so many ALzheimers studies with so many non-effective drugs..that they have a placebo Stat FOR EVERYTHING! You do not need an AD Placebo you can use the STATS and MAKE ONE UP! WHY are you going to FORCE people INTO Dimentia when YOU HAVE A SAFE TREATMENT? What the HECK is wrong with the medical profession?
If Anavex is SAFE and well Tolerated..THEN GIVE IT UP! You want your Mom getting the Placebo? Cut it OUT! This isn't a new disease..we KNOW want it does..The PLACEBO EFFECT IS GONE by 12 WEEKS..GONE..
Many Moons,
the good Dr. is playing a brilliant game of Chess ..He has probably dreamed of this game his whole life..If I ever...
Now, puzzle piece by puzzle piece,..I think Anavex is the reason PFE and ALllergan called off their merger..AND i think the REASON(which I previously speculated) ALLERGAN quickly made the $3.3 Billion Purchase of a Muscarinic Compound ..IS THE PFIZER and ANAVEX have already AGREED to partner....This will be what the good Dr. Uses to protect Sally and Jimbo the retail Investor Car Chasers..12 WEEK/ Partnership / Trial..
Apparently the Australian Trial is ALREADY RECRUITING!
trying to find a lo cal Maple Syrup..but I am with Ya!
Vicks Cough is 100% DM by the way..Coconut Flour, 100 % pure Maple Syrup
good to go until A2-73 gets here!
well alzheimers is a deadly disease..
and being able to play a piano versus not know your name is STARK..
what is your other point?
thank you for making MINE!
Placebo UNNCECESARY other to SAY that you had one..
i again repeat the IMMORALITY OF A PLACEBO ARM! We have ALL THE AD PLACEBO INFO we NEED! We have a MORAL OBLIGATION to give people a MEDICINE that WORKS! It is outrageious to give PLACEBOS to people diagnosed with Moderate AD when you have a Drug that offers not ILL and perhaps a treatment! Immoral!
Miss Australia! WOnderful to hear from you. Did you see Goerge's post re: Mryistic(?) Acid? Google Myristic Acid and Signma 1 receptor..Coconut is a food/oil source with Myristic Acid..I am in tears over Piano player..what Joy!
just a fantastic find..May 11th..it was just published..
this has been an educational road for me..well enjoyed..
By definition the lower AVXL goes the lower the risk for a buyer..
One likes to see trends up..easier to average up psychologically..
the delay is what it is..i would be more upset releasing 12 Week and interim 26 Week only to see A Fuerstein an dShrkeili get rich scaring the crud out of Car Chasing Retail..Seeing the shorts make that easy scared money makes me sick..
Thought Anavex was in hurry to release 12 WEEK and Interim 26 WEEK, but on hindsight, I do not think they are.
ALL Anavex is concerned about is Phase 3 start with FDA approval and enough confidence from 12 WEEK to choose the dosage..
the good Dr. is not going to give away the Ship to BP Partner..so negotiations..must have tremendous due diligence..on both sides..
the good Dr. MUST get 12 WEEKS right.. goodbye April, hello May..
agreed! like aspirin when we are 103!
think A3-71 will be given Fast Lane after A2-73 continues on it's successful path..
Cross Prescription, from what I understand, is allowed and practiced. so when A2-73 gets approved..and say A3-71 gets approved for Frotal DM, than my guess is , some lucky will be getting both..
Ladies and Gentleman,
I think I have figured out what is happening with the Motleys and Fuersteins of the netherworld.
When a company has a run up like Anavex they almost always raise capital at the newer, higher valuation. 99% of the time..honestly..so what these guys do, ILLEGALLY , is Short Sell the stock BEFORE or DURING the Quiet period of the secondary..before it's market news, and then BUY BACk the Stock in the open market AFTER the secondary when the price is lower. Illegal as all get out..but VERY PROFITABLE..Very close to a SURE THING! They STEAL from shareholders before they KNOW there is a secondary coming!
LET ME TELL YOU WHAT THIS MEANS LOGICALLY:
1. NO Secondary coming. The good Dr. will not cheapen ours or his ownership at this ridiculous price! BAM!
2. The Motleys of the World KNOW IT and they are SCARED out of their minds, because NOW the 12 WEEKS are coming ..and they got No Place to Run and No Place to Hide..
3. This is all about to play out very very soon.
https://www.sec.gov/News/PressRelease/Detail/PressRelease/1370539804376
thank you george..a good read..especially the part i could understand!
Short Sellers filling the Up Gap to stop Technicians..
What do they care..someone is going to cover their losses..
Wickedness is afoot..IMO
Sounds like a cheer!
I believe that I am right..
my anavex shares , I will hold TIGHT!
haha.. good one SOKOL..
Anavex is preparing for the Storm when they release the 12 WEEK..It must be OFF the CHARTS!
look two things: the Data is going to be REVOLUTIONARY! A3-71 Getting Orphan Status means FDA believes Anavex has First in Class Drug for CNS Diseases. PERIOD.
Second: Todd Cambpell of Motley Fool said this in 2011:
###Alzheimer's disease is so tough to treat, it's hard not to be excited about ANY drug that shows promise in trials, even if those trials happen to be very early stage. And it doesn't get much earlier-stage than Biogen's BIIB-037, a drug that was most recently in phase 1 trials designed to establish safety, not efficacy.####
The CAPS are MINE:
Stop whining about Data release..it is so OFF THE CHARTS UNBELIEVABLE.
They are Preparing for RESPONSE..Positive and Negative..SO GET OVER IT.
The BEST POST on Anavex EVER! Sorry DADO..and Chemist..OUT of the PARK!
How can ANYONE write an article about Anavex and Valuation/Speculation without including $3,000,000,000 Valuation of Heptares for muscarinic drugs?
ESPECIALLY if you are saying that $200 million is TOO MUCH and not worth it? Motley Fool is Playing YOU the FOOL..
so in my other life our firm represents Insurance Policy Holders who have suffered a catastrophic loss. The FIRST thing the Insurance Co. tells them is NOT TO HIRE US! Then the RESTORAL Co. tells the Client NOT TO HIRE US! then their Agent tells them..well you get the picture..
and guess WHY they all tell them NOT TO HIRE US! Because we
Represent THE INSURED very well, which means ..USUALLY,
It costs them all a lot of MONEY!
Does this scenario remind anyone of a similar situation?
Tom , they used last Quarter that included Stock Options for Missling et al. expensed out..Total Crud..we are at about $1.5 Q..maybe somewhat higher with new employees and larger PR and Accounting Firm..BUT you have to
be prepared for success if you are going to be succesful..
Which we are..ask the FDA!
FOOL me once! FOOL me TWICE? never LISTEN to my
Motley Advice! $1.5 Million Q Burn turns into $4.5 Q Burn (Incl.Annual Stock Option EXP.)
We will get Partnership before Dilution OR..
We HAVE SOC for Alzheimers and get Diluted at $5 Billion ..
I can live with either..go good Dr. Go!
great post..why else pay $3 billion for a drug that is nowhere near as effective or close to License as Anavex..
means DEAL is CLOSE BABY! I'm so excited..and I just can't hide it..
I need some A2-73 before I lose my mind..
and I like IT! Come on good Dr. the appetizer was most excellent!
Tasty, yet not too filling, A Surprise addition
for our palates to enjoy. We await the main course!
But we have seent the Dessert Tray and it holds quite the
Delight.
From Preliminary 26 WEEKS, Another IND for A2-73, a new Phase 2a Trial for A3-71, a new Phase 3 Trial for IND(Depression/Anziety?Rett Syndrome), the SURPRISE Tray!, It's like having dinner in a Bakery! The desserts seem endless! Thank you good Dr.!