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Why there is NO SHAME in ACCUMULATING SHARES
PART1
Let's start with Poster 1:
The MTD determination from the present Phase 2a study, allows for
a Phase 2/3 study to be conducted according to a double-blind
design including placebo. To complete the design of a future study,
population PK data (and the evaluation of inter-patient variability) are
necessary in order to compute the patients’ sample size and to
achieve conclusions associated with a given statistical power. This is
currently in progress.
• ANAVEX 2-73 may have a broader scope in addressing diseases by
virtue of both its molecular biology and the favorable safety profile
observed thus far. Estimating MTD is a prerequisite for the
progression of ANAVEX 2-73 towa
rds further clinical trial
the number of side benefits:
16 Events reported with the Preferred Term of ‘Therapeutic Response
Unexpected’. A sample of verbatim terms reported include:
ü Improved Engagement with Family/Friends
ü Improvement in Mood
ü Increased Independent Activity
ü Feeling Happier
ü Improved Alertness
ü Better Coordination
ü Better Coping
SAFETY:
96% of all AEs were mild or moderate and 83% events are
recovered/resolved. AE profile similar to that of healthy volunteer Phase
1 data (Schindler 2
So ACCUMULATE based on THIS if nothing else..
Blzzy..nothing unreasonable about anything you said..
Legal is running the show at Anavex as far as what gets announced and when..
I am still very positive, but disappointed at the breakdown at 26 weeks..
AD is some wicked wicked stuff..
Surely Anavex will have other positive announcements shortly..
the good Dr.'s salary increase amounted to an additional $25,000 per month..(frmom $200k to $500k annual..
i am betting we see where that money is coming from shortly ..
or PK or Epilepsy or Depression or Rett Syndrome..
Anavex is Dramatically undervalued..but I would have to say..
not as dramatically undervalued as I had hoped..
there are going to be some big swing days ahead..
also..
the Phase 3 is going to happen..with FDA Guidance..
by new Salary structure with the good Dr...one way or another the financing is already in place..
longer review..but my expectations were too high..
Safety proved..
Efficacy for 12 Weeks..Proved..
Stability after 6 months..12 months..still there..
But ladies and gentleman..Delaying the regression of Alzheimers for 6 months..at any level..means the world to family, patient, caregiver, societal costs..
accumulate..it's still beats the hell out of anything else..
but it is going to be a bit longer before we may groundswell
availability..too bad
the public not selling here..shorters are..
the 12 week data is fantastic..new SOC
Shorts rand this down..
Phase 3 coming soon..
the public not selling here..shorters are..
the 12 week data is fantastic..new SOC
Shorts rand this down..
Phase 3 coming soon..
here we are, saddened at what does appear a barrier of sadness at 6 months.
this was supposed to end the 2a study but it was extended..good. the additional data will help.
there are many postives..at 12 weeks..ANAVEX ROCKS..
we need to get ANAVEX to Patients SOONER rather than later..
The side bar Depression Benefits have got to be recognized..
Sleep affected positively by almost 30%!
For caretakers, family members and the patients..better sleep for
one night is a Godsend!
Curative is the 12 week response..but the Beast returns..Doggonit.
Longer and Better than anything else..very positive..
My disappointment is not with the company nor the drug.
my disappointment is for the families and sufferers..
this Beast is hard to kill
NO one of the Arms of the Phase 3 can be no other drugs..
Taurx is doing a total study with no other drugs..
Exactly! Why would you withold medicine from a dying man or woman
If you knew there was a 50/50 chance it could save their life,
And almost a zero chance cause them pain?
Death by AD is As bad as any other Deadly Disease!
Give them the A2-73 Now.. Personally,, the 11 out of 14 at 12 weeks was enough for me..
Feel like I am at Chinese Fireworks Factory , about mid Ju e..
And someone just has to have a cigarette ..
30: and counting
Taurx..not necessarily a Failure..might be synergistic..
15% of population say it worked..interesting..will read more later..
But the Taurx study prima Facia not a total fail..
Wolf..
i think I go with HESS..release at time of Poster..
BUT this is great to know..so if we do see PR before we KNOW..
..I mean KNOW presentation was well planned..
also this can be taken both ways..Honestly..great back and forth..
Hess, that is GREAT NEWS! No fake morning run up before the market opens t try and suck the life out of a rally as the market makers TRY to short the top.
So we will have active trading as the poster hits and everyone reads..
WWW
the wild wild west..oh and XENA..God Bless ya' for mentioning the P2/3 Potential Announcement..
can you even imagine the announcement of great Data and P2/3 License Deal?
Oh my..Where did the good Dr. get so much cash for his new salary?
Tomorrow is when the real fun begins!
i think the Poster will be released first thing in the morning like the First Poster for AAIC. I hope they don't release it until AFTER trading starts..but think it will be released before..
we shall sell
No doubts as to morality or ethics of leadership team..
No doubts that people are getting better and have been for quite some time taking a drug that was "discovered" over a decade ago?
No doubt that Data will support PK regarding effect of improvement..
I have no doubt that one way or another A2-73 will be crossing the Counter in 2017 to help treat the afflicted..
The beat down will soon turn from focused on people who BELIEVE
to the people who CONTROL ACCESS..
I have no doubt the CHORUS for A2-73 is about to become VERY,VERY
LOUD
hope is not playing the piano or painting pictures or playing golf.
hope is not how we have gone froma market cap of $20 Millinto $260 Million..
People getting better is what drives Anavex..
2 years of continuing Data from 2a PART B..2 more years!
hope is NOT what is driving Anavex..REALITY is
2 Important notes:
1. Adverse Affects were labeled as the same as one would find for a Phase 1 Healthy Volunteer Group..THAT by itself is UNBELIEVABLE!
2. the good Dr. gave himself a hefty cash pay raise..where is he going to get the cash to pay for that raise?
My guess is..the good Dr. is getting his hefty pay raise from the $$$$ that will be covering the cost of the A2-73 Phase 3 Trials..
Exactly
great post ipulator
thank you
Hess..
You missed the ongoing Anti-Depression Testing..
I think they may have INTERIM ADCS-ADL for 38 Weeks and 52 Weeks..maybe..
Also...do PK Tests continue? or are we done with PK until Phase 2/3?
ok..so how many patients are in or out or back in or replaced..
kind of hard to do the math based on Poster..looking like 27-28 Patients left..I don't know how they treat the response rate regarding people who dropped out..do they include them in %'s or not? I assume they do..
i was thinking an 85% effect rate..that seems like it's going to be high..
Also..since positve mention of high cognitive response rate at 5 weeks..
the 12 and 26 weeks estimates may need to be lowered from 6 Points up to
say 5 points up..Still Rock Star Status..I am duly impressed that a patient suffering cancer and who begins Chemotherapy LOVES A2-73 so much that they continue taking A2-73 during Chemo. That is belief! They KNOW what is at stake! Cancer isn't the ONLY KILLER stalking them. Hope this patient kicks Cancer's derriere!
here some more gleaned gems:
"May have a broader scope in addressing diesasES!" Again MULTIPLE IND.
-16 Positive unexpected Therapeutic response Events- Don't know HOW these Events are accounted for? Was it 16 Patients that enjoyed one or more of these events, was it 16 different types of Benefits Enjoyed by different patients...Mood Improvement, Family Engagement..Activities(AKA - LIFE!)
So the reason this sticks out for Caretakers..is because..this is DIFFERENT FROM WHAT CARETAKERS EXPERIENCE with other AD Patients..THUS..the UNEXPECTED in Statement Title..
or NOT LOSING THEM IN THE FIRST PLACE!
to the Heroes of the first Trial of A2-73 that have left due to
whatever reason, i say, THANK YOU! You are a hero to me and to everyone who desires an end to this wicked disease. I Pray fo ryou and your family, that perhaps your health will hold and an adjunct to A2-73 may be found or another succesful route. the Love of the Eteranl Creator awaits all who believe and love..May peace find you in this world and eternal joy in the next. Life is short, Love hard
They list out all the other observed POSITIVES in Poster..
her e is the one I like the most..\
more interaction with family..
Short that blackhearts
50 MG is Maximum Tolerated DOSE! FANTASTIC!
That is what I got out of all of this..
50MG a DAY keeps AD AWAY!
Major Tom to Gorund Control!
i appreciate Miss Australia's posting, both her good and her not so good. Such is life. honesty is always appreciated, sometimes not welcome, but always appreciated. She and her family are in my prayers. I look forward to meeting her someday maybe, and I consider all the Trial Participants and their family's heroes. God Bless Miss Australia!
how could one argue..i will not..Come on ANAVEX!
Yes! Sunday i think we just get overwhelmed with Proof Positive that Wednesdays Data is NOT FLUKE! IRREFUTABLE..But Sunday DATA will still give insight for Wednesday's Data....The Question is ..
will the data be enough? My answer as usual...
It already IS! Don't understand what everyone else is waiting for..
the Fat Lady to Sing? Cute girl on the Piano's not enough? A pretty oil painting? Tough crowd..TUFF!
F1 ..will try to find time tonight and have tomorrow
it is not just "cognitive" it is overall QUALITY of life..Anti-Depressive-Anti-Anxiety- Better sleep, less stress..BBB..bam..Honestly..
Xena IMO due to the longer time of ONSET of AD people and so many past failures the community NOW treats potential treatments like they have ALL DAY..Alzheimers is CANCER of the Identity! Everyday, more of WHO YOU ARE IS LOST FOREVER! Chances are Anavex is just going to STOP THE THIEF..maybe A2-73 will help get back some of the stolen memories..
We have to TREAT Alzheimers with same urgency and FDA response as if ti were A DEADLY CANCER..If ANAVEX proves to be 50% EFFECTIVE with NO SIDE EFFECTS..we need BTD and COMPASSIONATE USE..Let the Patients DYING take the RISKS..For goodness sakes..
Looking for anywhere OVER 68 on ADCS-ADL is a HOME RUN..ANAVEX NOW..BTD..You be the Blind Mouse PLACEBO but GIVE ME THE DRUG!
Normal Score on Alzheimers patient at 6 months would be 60 or BELOW..
NO PLACEBO EFFECT AFTER 12 WEEKS..NONE..Get ready for the GREATEST WEEKEND EVER!
PLEX..i posted earlier how I derived at +6 ..YES it is a GOOD NUMBER..
I think it might be low..here is how I came up with from earlier post:
I changed some of the wording but left conclusions the same..
it is simple math and deductive reasoning..
at least 10%(I actually ASSUME a HIGHER NOMBER) of 32n study has if not fully recovered, close to and since the ADCS-ADL test is quite basic..their improvement on their score should be substantial.
The % of overall effected is 80% ..at least..probably higher since we KNOW that we have PK Effect SO the low responding 3 mg dosage is eliminated and a more positive effect from higher & longer dosage..
75% up 5pts 69 X .75 of 32 =24= 1656
10% up 10pt 74 X 4 = 296
start at 64 pts Educated Guess for ADCS-ADL at 26 WEEKS = 69.71 pts
UP 5.71 PTS..
Patients with ZERO HELP..probably even with Aricept Down 4-5 Points at 6 months..or ..linear decline from Trial start..usual progression of AD..
59pts would be average ADCS-ADL score
it is not complicated..made very few assumptions that do not make sense based on past reports and announcements..
what do YOU THINK this ADCS-ADL number or a very like number will do
to Anavex? Especailly when ALL THE OTHER TESTS back up COGNITIVE IMPROVEMENTS ..
predicting +6 on ADCS-ADL and over 80% of population positively effected.
Other Data to CONFIRM this result. Normal Patients without or really WITH any treatment will be DOWN on ADCS-ADL Test 4-6 Points at 6 months.
Demand Breakthrough! Demand IMMEDIATE FDA ACCESS through ANY PROGRAM!
COMING SOON:
Anavex NOW!
As the Scientific Medical types go once again into the scrum of despair fro Placebo and Blinds, some of us will begin a very different approach to A2-73 Approval. anavex now...have not decided the time or resources to expend yet..but i believe the upcoming Data will Demand immediate A2-73 Action.
Demand it...
You are probably correct in that a groundswell for ANavex will not occur UNTIL the DATA is PUBLIC. I can not call a Congressman for 11 out of 14 without MORE DATA to back it up. We shall soon have our DATA, then "let slip the dogs of War"..
The Dye is not yet cast..but soon my friends..soon
i don't understand how we are not through $30PPS or higher..
loss for words..i thought people could read..oh well ..soon enough
so..the Shorts keep shorting ANavex AFTER they announce they have the Drug to Treat Alzheimers. Truly it is unnerving. Would BP destroy the only treatment for Alzheimers to keep people sick and that they may make profit?
That i even ask the question makes me sick
thanks Jimmy! fun song
somone post 6-31 Short Sales at 4.2 MIllion shares.
That makes me feel better..
we don't have to find that many buyers to move this stock past $14 to
new all time highs..we have 4.2 million shares just waiting to buy back in..Thank You Shortie Mc Short Short and Corey and Fool and AF..and all you haters of the only treatment for AD..because you all are not very nice.