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They DID NOT pivot!
Cog and ADL ORs were significant (per the SAP) to highlight patients who IMPROVED and remain so... no change.
Cog and CDR scores were stat. sig. and remain so...
Further investigation on Cog and CDR identify better results than initially found, with P < .025
The biomarkers discovered were identified back in Dec... and brought to light in the 9/14 PR.
There was no pivot... just additional detailed data... and ALL of this data will be presented to the FDA.
It's not that hard.
Never... never give a FUDster a break.
You're such a blathering idiot. Please stop with your pompous posts.
Jin informed you that your statement is absolutely false...
we clearly have co-primary endpoints and both need to be hit.
Ridiculous blather! There was no pivot, just additional detail of the successful results, plus identification of key biomarkers for AA pathway.
Psychotic idiot.
Idiot.
You've done revealed yourself as a FUDster. Keep that in mind when you post next.
Good riddance, FUDster! Don't bother coming back.
You're so full of schitt it's not funny.
We know a FUDster when we see him... and you are him.
Me too... it's rather obvious.
Congrats... you got 100% FUD "Likes". You're on a roll, Dr FUD.
If you're siding with kund, then you're either a kook or a FUDster.
He's never had a rational valid post ever... only pure FUD nonsense.
It's what he's paid to do.
Not afraid... active living and healthy eating are lifestyle choices. To do otherwise and ignore the potential harm is quite risky.
Gotcha. If the collusive shorts are buying instead of covering now, then is there another takedown planned?
Sounds rather risky when the outcome of approval is rather imminent.
Yes... good quality organic olive oil, avocado oil, coconut oil, pastured (Irish) butter, ghee and macadamia oil.
Good fats, even saturated, are very healthy for you. The past myth of "low fat is good" has been debunked.
The purpose of borrowing shares is to short.
stay away from sugar
I think it's a good situation that most all shares have been lent out/shorted long ago... not much left to borrow and short. This should set up well for continued covering...
Yes, that's what Anavex (Jin) had stated, in the PR... thus, making ADCS-ADL immaterial, even if good.
• Odds Ratio of ADAS-Cog meaningful improvement in cognition at threshold of -0.5 points or less (90% CI) 1.839 (1.17, 2.94) P = 0.015
• Odds Ratio of ADCS-ADL meaningful improvement in function at threshold of +3.5 points or higher (90% CI) 2.67 (1.17, 6.13) P = 0.0255
• ANAVEX®2-73 treatment slowed cognitive decline by 45% compared to placebo at 48 weeks
• Mean difference in ADAS-Cog score change of -1.85 points
• Compared to placebo, ANAVEX®2-73 (blarcamesine) reduced clinical decline of cognition and function by 27% with mean score difference of -0.42 points (p=0.040) as measured by CDR-SB
• ADCS-Cog and CDR-SB (p < .025) proving further evidence of stat. sig. improvements.
• Identification of two key biomarkers for AA pathway option.
I couldn't get past the first nonsensical sentence of your FUDiatribe.
Missling knowing that the company did not meet all endpoints and have a likely fail in sight?
Not true...
we're going the AA route because a full approval is pretty much impossible without hitting it.
It's clear to most investors that the Cog & ADL ORs were presented in the first PR and CTAD to highlight the strong responders, along with stat. sig. Cog & CDR mean scores. It was the purpose of the presentation to demonstrate patient IMPROVEMENT in the trial, differentiating it from all other past AD P3 trials. That was clearly accomplished. Since the ORs were pre-specified in the SAP that data alone was sufficient to proclaim the trial a success in meeting endpoints.
What the Sept 14 PR accomplished was not only to detail how ADAS-Cog and CDR-SB calculations alone (each with p< .025) make for an acceptable FDA trial result, but also identified 2 key biomarkers that will facilitate an AA pathway option. Whether ADCS-ADL had a p < .05 is now immaterial.
It's only the common FUDsters who keep trying to make an issue of ADL as they disregard all of the significant data that will lead to FDA approval, with the OLE likely becoming the confirmatory trial.
You and raja are quite the FUD couple...
... won't happen until sometime Anavex might release solid and complete data
LOL! That's perfect!
Loading up where the criminal cartel is buying is smart buying. Bring it, FUDster!
Just to call you out is satisfaction... because you're not blatantly obvious as most, but you are.
Yep, there's sooo much FUD being posted daily that it's a full-time job calling it out.
It's hard to be bothered about the truth, right?
You're the one selling crap, FUDster... by suggesting we haven't seen REAL NEWS yet. Complete BS!
One has to be a cabal soldier to know the answers to your questions.
All that investors can do is wait it out and buy more.
Why not buy where the WS criminals plan to buy?
Cabal soldiers, including AF, can take stellar irrefutable Rett data and spin a false narrative as cover for a short attack.
We've seen it with every positive PR for the past several years. So don't give us your crap about REAL NEWS, FUDster.
Not a chance of any frivolous suit. This is 100% collusive manipulation.
A common tactic by the criminal cartel prior to NDAs and approvals... to scare out retail and gather up cheap shares for themselves.
FUDsters here try to turn all real news into fake news. Don't ya'll?
Take advantage of the collusive manipulation. I'm loading up here. Great opportunity to buy at depressed levels a company that'll deliver the next SoC for Rett and AD.
Got more cheapies sub $7! How about you?
Don't forget the pompous idiot camp, that which you sit alone.
Your BS narratives are DOA. Pathetic FUD.
It's pretty easy to see who the paid cabal soldiers are here, who try to hide their collusive SP manipulation with nonsense narratives... plain FUD!
Stop with the FUD nonsense. We all know this is organized manipulation prior to NDAs and approvals.
It happens all the time to targeted biotechs.