Romans 12:19
Register for free to join our community of investors and share your ideas. You will also get access to streaming quotes, interactive charts, trades, portfolio, live options flow and more tools.
Register for free to join our community of investors and share your ideas. You will also get access to streaming quotes, interactive charts, trades, portfolio, live options flow and more tools.
this is a blog.. so what ! eom
This is pocket change to the eye's who are taking notice now !!
at these low prices it's worth the risk IMO eom
SRGE 4sure :) eom
They're going 4it.. dig/extract = $$$ eom
JV means metal recovery = more$$$ IMO eom
uT oH..BOOM.. GO SRGE :) eom
WOONSOCKET, R.I., Dec. 26, 2012 /PRNewswire/ -- MultiCell Technologies, Inc. (OTC Bulletin Board: MCET) presented at the 2012 American Society for Cell Biology® (ASCB®) Annual Meeting in San Francisco, CA, on Tuesday, December 18. Simona Bot, M.D. presented preclinical research results in an abstract titled "Short Synthetic Double Stranded RNA with Dual Activity - Oncolytic and Immune Modulatory - for Hepatocellular Carcinoma."
This research was supported by MultiCell via a sponsored research grant with the laboratory of Anand Ghanekar, M.D., Ph.D. at University Health Network, Toronto General Hospital Research Institute, Ontario, Canada. The scientific results presented by Dr. Bot added key information regarding the capability of MCT-485 to elicit highly pro-inflammatory cytokine by human monocytes, and death of human liver cancer cells, mostly through a mechanism distinct from apoptosis. Together with the data previously presented at the Association of Cancer Immunotherapy (CIMT annual meeting, May 2012, Mainz, Germany) describing the direct anti-tumor cell effect of MCT-485 on multiple human liver cancer cell lines in vitro, the novel scientific evidence supports the model that this synthetic dsRNA molecule could mediate a two-pronged effect within the tumor environment: destruction of the tumor cells and activation of the stromal monocytes. The latter could amplify the immune system's capability to fight off tumor over a longer timeframe.
Altogether, these data sets, generated for the first time with MCT-485 manufactured using a state of the art process, as presented at CIMT and ASCB® 2012, support further studies exploring the preclinical safety, effectiveness and clinical utility of this candidate as a novel therapeutic agent for hepatocellular carcinoma.
About MultiCell Technologies, Inc.
MultiCell Technologies, Inc. is a clinical-stage biopharmaceutical company developing novel therapeutics and discovery tools that address unmet medical needs for the treatment of neurological disorders, hepatic disease and cancer.
For more information about MultiCell Technologies, please visit http://www.multicelltech.com. For more detailed background on the presentation refer to the September 27 news release, and the poster archived on the site.
Caution Regarding Forward-Looking Statements
WOONSOCKET, R.I., Aug. 10, 2012 /PRNewswire/ -- MultiCell Technologies, Inc. (OTC Bulletin Board: MCET) is pleased to announce the updated preclinical research results for MCT-465 and MCT-485. MCT-485 showed in vitro dose-effect cytotoxicity on several human hepatocellular carcinoma cell lines. MCT-485 induced robust TNFalpha and some IL-6 expression. In contrast, MCT-465 showed no cytotoxicity or anti-proliferative effect. The research results support further mechanistic and in vivo studies exploring the safety, effectiveness and utility of MCT-465 and MCT-485 as novel therapeutic agents as a treatment for hepatocellular carcinoma and other cancers.
Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer and a leading cause of cancer death. Current pharmacological approaches for the treatment of human HCC are very limited in their efficacy. A potential role for noncoding double stranded RNAs such as MCT-465 and MCT-485 in the control of tumors has recently emerged in a variety of models with recognition of their ability to stimulate an immune response or directly affect cell death.
According to the National Cancer Institute, annually in the United States there are approximately 21,400 new cases of primary liver cancer and intrahepatic bile duct cancer, and approximately 18,400 of those cases resulted in death. Primary liver cancer, resulting from Hepatitis B and Hepatitis C infection, is the most common cancer in some parts of the world with more than 1 million new cases diagnosed each year. Primary liver cancer is rarely discovered early, and often does not respond to current treatment.
About MCT-465 and MCT-485
MCT-465 and MCT-485 are the first of a family of prospective cancer therapeutics based on the use of our patented TLR3 signaling technology. MCT-465 and MCT-485 are in preclinical development, and are being investigated as prospective treatments for primary liver cancer and triple negative breast cancer. MultiCell owns rights to several issued U.S. and foreign patents and patent applications related to MCT-465 and MCT-485.
MCT-465 is a high molecular weight synthetic dsRNA (polyA:polyU, of 70bps) with immune enhancing properties. The mechanism of action of MCT-465 is pleiotropic and mediated by RNA sensors – such as TLR3, 7/8, MDA-5 and RIG-I - expressed by antigen presenting cells and select cases, by tumor cells:
•Induction of pro-inflammatory, immune enhancing cytokines locally and systemically;
•Anti-angiogenic effects through a local exposure to IL-12 / IFNgamma;
•In select cases, direct pro-apoptotic anti-tumoral effect.
MCT-485 is a low molecular weight synthetic dsRNA (polyA:polyU of 5bps) with direct tumor cytolytic properties. The mechanism of action of MCT-485 is pleiotropic yet distinct from that of MCT-465:
•Induction of tumor cell death upon direct exposure, while normal cells are minimally affected.
•Production of TNFalpha by cancer cells resulting in amplified tumor cell death and a localized immune reaction that has the potential to generalize and curb progression of metastatic cancer.
About MultiCell Technologies, Inc.
MultiCell Technologies, Inc. is a clinical-stage biopharmaceutical company developing novel therapeutics and discovery tools that address unmet medical needs for the treatment of neurological disorders, hepatic disease and cancer. For more information about MultiCell Technologies, please visit http://www.multicelltech.com.
Caution Regarding Forward-Looking Statements
Any statements in this press release about MultiCell's expectations, beliefs, plans, objectives, assumptions or future events or performance are not historical facts and are forward-looking statements for purposes of the Private Securities Litigation Reform Act of 1995 (the "Act"). These statements are often, but not always, made through the use of words or phrases such as "believe", "will", "expect", "anticipate", "estimate", "intend", "plan", "forecast", "could", and "would". MultiCell bases these forward- looking statements on current expectations about future events. They involve known and unknown risks, uncertainties and assumptions that may cause actual results, levels of activity, performance or achievements to differ materially from those expressed or implied by any forward-looking statement. Some of the risks, uncertainties and assumptions that could cause actual results to differ materially from estimates or projections in the forward-looking statement include, but are not limited to, the risk that we might not achieve our anticipated clinical development milestones, receive regulatory approval, or successfully commercialize our products as expected, the market for our products will not grow as expected, and the risk that our products will not achieve expectations. For additional information about risks and uncertainties MultiCell faces, see documents that MultiCell files with the Securities and Exchange Commission, including MultiCell's report on Form 10-K for the fiscal year ended November 30, 2011, and all of MultiCell's quarterly and other periodic SEC filings. MultiCell claims the protection of the safe harbor for forward-looking statements under the Act and assumes no obligation and expressly disclaims any duty to update any forward-looking statement to reflect events or circumstances after the date of this news release or to reflect the occurrence of subsequent events.
SOURCE MultiCell Technologies, Inc.
Copyright 2012 PR Newswire
WOONSOCKET, R.I., Sept. 27, 2012 /PRNewswire/ -- MultiCell Technologies, Inc. (OTC Bulletin Board: MCET) is pleased to announce the acceptance by the American Society for Cell Biology® (ASCB®) of abstract "Short Synthetic Double Stranded RNA with Dual Activity - Oncolytic and Immune Modulatory - for Hepatocellular Carcinoma." The preclinical research results will be presented by Anand Ghanekar M.D., Ph.D., Division of Cellular & Molecular Biology, Toronto General Hospital Research Institute, at the 2012 ASCB Annual Meeting in San Francisco, CA, December 15-19, 2012.
Poster Session: Cancer Therapy II Day/Date of Presentation: Tuesday, December 18, 2012 Time of Presentation: 12:30 PM - 2:00 PM PST Place: Exhibit Halls A-C Presentation Number: 2444 Board Number: B1425
Dr. Ghanekar's research was supported by MultiCell via a sponsored research grant with the University Health Network, Toronto General Hospital Research Institute, Ontario, Canada. The research results to be presented by Dr. Ghanekar support further mechanistic and in vivo studies exploring the safety, effectiveness and utility of MCT-465 and MCT-485 as novel therapeutic agents as a treatment for hepatocellular carcinoma and other cancers.
About MCT-465 and MCT-485 MCT-465 and MCT-485 are the first of a family of prospective cancer therapeutics based on the use of our patented TLR3 signaling technology. MCT-465 and MCT 485 are in preclinical development, and are being investigated as prospective treatments for primary liver cancer and triple negative breast cancer.
The immune system is composed of two synergistic elements: the innate immune system and the adaptive immune system. Stimulation of the innate immune system through key receptors plays a critical role in triggering the adaptive immune response stimulating T and B cells to produce antibodies. In cancer, this integrated defense system does not work well, resulting in suboptimal activation of innate immunity and thus, late or inefficient adaptive immunity. The innate immune system is composed of a family of ten receptor molecules, the Toll-like Receptors (TLR1-TLR10), which act as sentries to identify invaders and signal the alarm to mobilize the body's array of immune defenses.
Within the tumor lesion, there may be infiltrating monocytes, dendritic cells and leukocytes in general, that have the capability to mobilize an adaptive or innate immune response but they are either silent or immune suppressive in the absence of select immune interventions. Such infiltrating non-cancerous immune cells may express TLR3, other TLRs, RIG-I and/or MDA-5. In addition, within tumor lesions, there may be cancerous cells or stromal cells or cancer stem cells which express TLR3, other TLRs, RIG-I and MDA-5 (representing RNA-sensing molecules).
Cancer stem cells are thought to play a role in a tumor's resistance to therapy. While significant progress has been made in developing cancer therapies that result in cytoreduction and thus tumor regression, the control of cancer over a longer interval and especially of metastatic disease, remains a key goal. Cancer stem cells are believed to be responsible for cancer relapse by being less sensitive to conventional therapies.
MultiCell owns exclusive rights to two issued U.S. patents (6,872,389 and 6,129,911), one U.S. patent application (U.S. 2006/0019387A1), and several corresponding issued and pending foreign patents and patent applications related to the isolation and differentiation of liver stem cells. The role of liver stem cells in the carcinogenic process has recently led to a new hypothesis that hepatocellular carcinoma arises by maturation arrest of liver stem cells.
Double stranded RNA (dsRNA) provides a therapeutic avenue for cancer treatment through (a) activating intra-tumoral leukocytes, abrogating their immune suppressive activity and/or (b) interacting with cancerous cells and directly inducing apoptosis, or indirectly through mobilization of immune effector mechanisms.
MCT-465 is a high molecular weight synthetic dsRNA (polyA:polyU, of 70bps) with immune enhancing properties. The mechanism of action of MCT-465 is pleiotropic and mediated by RNA sensors – such as TLR3, 7/8, MDA-5 and RIG-I - expressed by antigen presenting cells and select cases, by tumor cells:
Induction of pro-inflammatory, immune enhancing cytokines locally and systemically;
Anti-angiogenic effects through a local exposure to IL-12 / IFNgamma;
In select cases, direct pro-apoptotic anti-tumoral effect.
Prior studies with similar compounds support a strong immune enhancing effect of MCT-465, consisting in generation of Tc immunity against tumors, when administered as a companion to a vaccine. This raises the possibility that MCT-465 is an effective adjunctive therapy to any small molecule targeted therapy (such as tyrosine kinase inhibitors - TKIs) that results in release of endogenous tumor antigen while interfering minimally with the immune competence.
MCT-485 is a low molecular weight synthetic dsRNA (polyA:polyU of 5bps) with direct tumor cytolytic properties. The mechanism of action of MCT-485 is pleiotropic yet distinct from that of MCT-465:
Induction of tumor cell death upon direct exposure, while normal cells are minimally affected.
Production of TNF-alpha by cancer cells resulting in amplified tumor cell death and a localized immune reaction that has the potential to generalize and curb progression of metastatic cancer.
About MultiCell Technologies, Inc.
MultiCell Technologies, Inc. is a clinical-stage biopharmaceutical company developing novel therapeutics and discovery tools that address unmet medical needs for the treatment of neurological disorders, hepatic disease and cancer. For more information about MultiCell Technologies, please visit http://www.multicelltech.com
mmH ! eom
or we can all pitch in for an ole IBM ;) eom
cringe, we coulda sold at 015 and tripled our lots.. rrrrr eom ;)
optimism ugh! SHOW ME THE MONEY eom
Shoulda Coulda Woulda.. O'well, eom
..still holding ;) eom
..well then I guess that's it. eom
If they do come up w/something it may be fast tracked through the FDA ?? that stock you mention already popped 1.29 yesterday
The Biotech Industry has skyrocketed in 2012 as an increase in the number of new drug approvals has boosted investor optimism within the industry.
"In 2011, the U.S. FDA approved 30 new drugs, compared to 21 in 2010," S&P Capital IQ wrote in a note. "Through September 2012, the year-to-date total was 22. We see an improving trend for FDA first cycle review approvals and a rise in the rate of new drug approvals for rare diseases, which we think is helping to boost investor sentiment for the agency, after years of criticism stemming from inconsistency in making and communicating its decisions."
Another key factor in the Biotech Industry's success has been the "patent cliff" major pharmaceuticals have faced in 2012. Major drug manufacturers have looked to biotech companies to help offset major revenue losses from expiring patents as it is less time consuming than developing new drugs through R&D....... .
The Biotech Industry has skyrocketed in 2012 as an increase in the number of new drug approvals has boosted investor optimism within the industry.
"In 2011, the U.S. FDA approved 30 new drugs, compared to 21 in 2010," S&P Capital IQ wrote in a note. "Through September 2012, the year-to-date total was 22. We see an improving trend for FDA first cycle review approvals and a rise in the rate of new drug approvals for rare diseases, which we think is helping to boost investor sentiment for the agency, after years of criticism stemming from inconsistency in making and communicating its decisions."
Another key factor in the Biotech Industry's success has been the "patent cliff" major pharmaceuticals have faced in 2012. Major drug manufacturers have looked to biotech companies to help offset major revenue losses from expiring patents as it is less time consuming than developing new drugs through R&D.
Dis sucks, coulda doubled my share count twice.. o'well, shoulda never threw out that ole crystal ball.. rrrr
14th? w/the last PR does this date still stand ? eom
Buys VS Sells over past 2 weeks ? eom
mmh ? is this true ? eom
Sunshine Biopharma Inc. (OTCQB: SBFM), a pharmaceutical company focused on the research, development and commercialization of drugs for the treatment of various forms of cancer, today announced that it has completed a new IND-Enabling study in which Adva-27a, the Company's flagship oncology drug candidate, was found to be effective at killing Multidrug Resistant Uterine Cancer Cells in vitro. The study was carried out in MES-SA/Dx5, a Uterine Sarcoma cell line that has become multidrug resistant through the use of a commonly administered chemotherapy drug, Doxorubicin. Adva-27a was able to kill these cells with an IC50 of less than 8 micromolar, a very pharmacologically favorable drug concentration. Sunshine Biopharma had previously reported that Adva-27a is also capable of effectively killing Multidrug Resistant Breast Cancer Cells (MCF-7/MDR) and Small-Cell Lung Cancer Cells (H69AR) in vitro.
"This brings to three the total number of Multidrug Resistant Cancer types that Adva-27a can destroy. Other chemotherapy drugs are completely ineffective against these cancers," said Dr. Steve N. Slilaty, CEO of Sunshine Biopharma. "This confirms the general effectiveness of Adva-27a against Multidrug Resistant Cancer," he added.
About Sunshine Biopharma Inc.
Sunshine Biopharma is an early stage pharmaceutical company focused on the research, development and commercialization of drugs for the treatment of various forms of cancer. Sunshine Biopharma recently announced that it has initiated IND-Enabling studies for its lead antitumor compound, Adva-27a.
Sunshine Biopharma Inc. (OTCQB: SBFM), a pharmaceutical company focused on the research, development and commercialization of drugs for the treatment of various forms of cancer, today announced that it has completed a new IND-Enabling study in which Adva-27a, the Company's flagship oncology drug candidate, was found to be effective at killing Multidrug Resistant Uterine Cancer Cells in vitro. The study was carried out in MES-SA/Dx5, a Uterine Sarcoma cell line that has become multidrug resistant through the use of a commonly administered chemotherapy drug, Doxorubicin. Adva-27a was able to kill these cells with an IC50 of less than 8 micromolar, a very pharmacologically favorable drug concentration. Sunshine Biopharma had previously reported that Adva-27a is also capable of effectively killing Multidrug Resistant Breast Cancer Cells (MCF-7/MDR) and Small-Cell Lung Cancer Cells (H69AR) in vitro.
"This brings to three the total number of Multidrug Resistant Cancer types that Adva-27a can destroy. Other chemotherapy drugs are completely ineffective against these cancers," said Dr. Steve N. Slilaty, CEO of Sunshine Biopharma. "This confirms the general effectiveness of Adva-27a against Multidrug Resistant Cancer," he added.
About Sunshine Biopharma Inc.
Sunshine Biopharma is an early stage pharmaceutical company focused on the research, development and commercialization of drugs for the treatment of various forms of cancer. Sunshine Biopharma recently announced that it has initiated IND-Enabling studies for its lead antitumor compound, Adva-27a.
"This brings to three the total number of Multidrug Resistant Cancer types that Adva-27a can destroy. Other chemotherapy drugs are completely ineffective against these cancers," said Dr. Steve N. Slilaty, CEO of Sunshine Biopharma. "This confirms the general effectiveness of Adva-27a against Multidrug Resistant Cancer," he added.
I was thinking those 500.. shrs will be used by the insiders a year down the road when all is revealed and the stock is at a major price...
True :) eom
GO SRGE eom
sometimes the casino's are involved in the fix.
American business as usual.. eom
"excellent ((anticancer)) drug candidate" ..NICE, eom
Progress:29-Nov-2012
Other Events
Item 8.01 Other Events
As we have previously disclosed, we are a pharmaceutical company focused on the research, development and commercialization of drugs for the treatment of various forms of cancer. The preclinical studies for our lead compound, Adva-27a, a multi-purpose antitumor compound, were successfully completed in late 2011. We are now continuing our clinical development of Adva-27a by conducting the next sequence of steps comprised of GMP manufacturing, IND-enabling studies, regulatory filing and Phase I clinical trials. We plan to conduct our Phase I clinical trials for Adva-27a at the Jewish General Hospital, Montreal, Canada, one of McGill University's Hospital Centers. The planned indication will be multidrug resistant breast cancer as Adva-27a has shown a positive effect on this type of cancer for which there is currently little or no treatment options available.
We believe we have been making significant progress in our drug development program over the last three weeks, including the following:
1. We have completed six IND-Enabling studies and have several other studies under way. The data from these studies will form part of the IND Application which we are planning to submit to the FDA soon in order to get the go ahead for the human trials (Phase I);
2. We have 1 gram of our drug currently being synthesized for use in specific animal studies as required by the FDA;
3. We have obtained a quotation for GMP synthesis of 1 kilogram of our drug for use in the upcoming human trials (Phase I);
4. We have a new patent application covering new subject matter for Adva-27a currently in preparation which we plan to file with the US Patent Office by the end of the month or early next month; and
5. All other patents pertaining to Adva-27a (US, Europe and elsewhere around the world) have just been transferred to us and our licensor from the government research lab in France.
IMO they know there is a massive amount of gold and other metals, and they are getting support along the way from all the right sources to get the biggest bang for their buck "The American Stock Market" wake up.. the writings on the wall.
Riding The Wave !! eom
896% on 500 shares.. it's a jumper !
hahaha GO SRGE, (even though the game is fixed..)
CORAL SPRINGS, Fla., Nov. 8, 2012 /PRNewswire/ -- Trans Global Group, Inc. (PinkSheets: TGGI) is pleased to announce the Company will reduce its total Authorized shares by 20%.
TGGI will file with the Amendment with the State of Nevada after the 3rd quarter report is filed reducing the number of Authorized shares from 5 Billion to 4 Billion.
The Company will look to try to reduce the number of Authorized Shares again before the end of the fiscal year 2012.
After the filing of our 3rd Quarter Financials we will forward the report to our attorney for review so he may prepare the Attorney Letter to submit to OTC Markets which will then allow the Company to return to a "PK" listing.
The Company will issue further news as events unfold over the coming weeks.
The foregoing press announcement contains forward-looking statements that can be identified by such terminology such as "believes," "expects," "potential," "plans," "suggests," "may," "should," "could," "intends," or similar expressions. Such forward-looking statements involve known and unknown risks, uncertainties and other factors that may cause the actual results to be materially different from any future results, performance or achievements expressed or implied by such statements. In particular, management's expectations could be affected by, among other things, uncertainties relating to our success in completing acquisitions, financing our operations, entering into strategic partnerships, engaging management and other matters disclosed by us in our public filings from time to time. Forward-looking statements speak only as to the date they are made. The Company does not undertake to update forward-looking statements to reflect circumstances or events that occur after the date the forward-looking statements are made.
CONTACT:
Chris Clarke
chris@transglobalgroupinc.com
954-509-3749
SOURCE Trans Global Group, Inc.
Copyright 2012 PR Newswire
..at least we own the float !! eom :)