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where is the announcement mr. IR?
RNA-based drugs
Little hopes
Jun 14th 2007
From The Economist print edition
New classes of drugs that exploit the new RNAs are in development
DRUGS based on RNA interference (see article http://www.economist.com/science/displaystory.cfm?story_id=9333471 ) are still being tested, but they are moving within striking distance of the market. Opko Corporation, based in Miami, is planning its final round of clinical trials for an RNAi drug later this year. The drug is designed to halt a disease called wet age-related macular degeneration, which is one of the most common forms of blindness in elderly people. It works by stopping the manufacture of a protein called VEGF, which is over-produced in the disease.
In the past two years investment has poured into two larger RNAi specialists, which both claim more intellectual property than Opko. In September 2005 Novartis, a big drug company, promised one of these ambitious young hopefuls, Alnylam Pharmaceuticals, $700m if it creates real medicines from its science. In April 2006 GlaxoSmithKline, another of the pharmaceutical industry's ruling elite, dangled the same figure in front of Alnylam's main rival, Sirna Therapeutics. Then, in December, Merck gobbled Sirna for $1.1 billion—more than twice Sirna's stockmarket value. Although the company has finished only one clinical trial, Ted Tenthoff, of Piper Jaffray, an investment bank, thinks that price may prove cheap.
There is, however, an obstacle to turning RNAi into the next broad category of drug. Opko's eye treatment can be popped straight into the eyeball with a needle. Inside a cell, or an enclosed space like an eyeball, RNAi works like a charm. Often, though, a drug must hitch a ride in circulating blood to reach the diseased part of the body it is aimed at. RNA is not tough stuff. Enzymes in the blood destroy it quickly. Even those in a breath that is carelessly exhaled over a test tube can ruin an RNA experiment. Most RNAi drugs will probably have to be encased in lipid bubbles to protect them. At the moment RNAi companies are designing bubbles that unload their contents when they find the right sort of diseased cell.
If that problem can be solved, a subsequent wave of medicines might come from microRNAs. When a cell stops making a crucial microRNA, the proteins it would have controlled are produced in abnormally large amounts. Conversely, if the cell makes too much of the microRNA, too few of those proteins will be produced. These sorts of changes have been linked to Tourette's syndrome and to many cancers. Alnylam and Merck hope that restoring the microRNA's levels by adding it to the cell (or, by contrast, adding something called an antagomir, which sticks to microRNAs and prevents them working) will eventually remove the disease.
http://www.economist.com/science/displaystory.cfm?story_id=9333482
translation:
well written euniverse1
i agree with you 1000%!
pawson will get what he deserves, no worries.
i wish this guy only bad things and he should rot in hell!!!
hope that helps ;)
am i right that it is tomorrow again? :)
yep, pawson killed the first possible hype with dilution... i don't think this is playable again!
chu sold his 100 shares??? he's out of this?
weeeeeeeeee we're going to da moon ;P
ps: chu, no offense ;)
that's where we can make even more money on those plays ;)
was there a mail yet? :)
i don't think he learned anything... ;)
you actually believed that? ;)
is today tomorrow? ;)
didn't followed it that close lately...
but i agree that makes sense
time to get in this stock again :)
Target-IR? is that new??
it was a great flipper for me... i'm not complaining ;)
currently i'm long again :)
you said tomorrow were today!? your first IR job? ;)
i had no problem to buy with IB today...
AMUG IR guy pumping? :D
hope it works, have free shares left with AMUG ;)
Posted by: uniqueinsights
In reply to: None
Date:6/13/2007 12:30:27 PM
Post #of 112
Market makers are cleaning up the bids good time to get in...
http://www.investorshub.com/boards/read_msg.asp?message_id=20417955
maybe we see your movie in germany before it starts in the states like Spiderman? would be cool ;P
anyway, good luck :)
i'm not here for the quick flip, i really hope this is a stock you buy and hold forever ;)
also i really would love to see a higher shareprice, i have time :)
i thought we would trade higher after franchise news, it proofs the concept and took alot of risk away from investing here imho
maybe the timeframe of 4 years is to long for some?!
isn't it cool to be able to print your own money? ;)
still showing total volume of 27.500 shares in my trading app?
good to know... ;)
and you are?
happy birthday btw ;)
there is also a website...
http://uniqueinsights.net/Grandmontgold.html
tnx :)
i had a fat finger and sold some at .0001 :(
forgot to change from sell to buy
yup, still waiting (Interactive Brokers)
gap closing?
nice timing on your part ;)
sweet ^^
Yahoo changed the symbol already... to OPK-WI, what does the WI stand for??
http://finance.yahoo.com/q?s=OPK-WI
it's not the exchange... it's the companies that are either good or bad!
since this reverse merger started all, that was said, happend in a timely professional manner imo
so i look forward to the future of this company!
but time will tell... as always :)
GLTA
maybe SkySat is just a powerpoint presentation yet, like Magic Money was?
It appears the SkySat is ready for flight
HUH? wich part of the PR makes you believe that?
haha, i heard of that... :)
USXP? i wouldn't want them for free ;)
i also bought 1 share... through IB, $1 commission and 0.0011 for the share ^^
hmmm, 1 share should do it...
http://www.investorshub.com/boards/read_msg.asp?message_id=20308118
guess it doesn't count if you don't have the physical cert...