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Just curious, anyone ever tell you that your style sucks? Google AXXHOLE.
Biostockglub...predictions??? If my memory is correct you have had very good accuracy and content predictions in the past on what happens next.
Can you look into your crystal ball and comment on what you think will happen next w/AVXL and the world around sp? It feels to like something is going to play out soon.
TIA
Doc328, thanks for the information.
Thanks Biostockclub...will need to keep a watch for LLY amyloid developments.
Jimmy667:
Biostockclub:
Peter is a great guy and brilliant thinker. I did a 2 year intern task/workout w/him.
Dr. Peter Senge has done great work in systems dynamics @MIT. (his book, "The Fifth discipline" is helpful). He describes a number of archetypes, many of which might be applied here. One of his archetypes is called, " fixes that fail". One characteristic is a process that keeps getting repeated in spite of unintended consequences, (previous failures) usually w/ follow up delays. (nothing new) People who have found themselves in one of these management death spirals will tell you how hard it is to detect your own process failures. Talon would tell you that the term "Death spiral" has a very specific meaning for pilots and it is easily analogous to what has happened in the CNS disease space. Hint, pulling back on the stick while in a death spiral only accelerates the out of control dive condition, the opposite of what seems intuitive. IMO, the Scientific method of reasoning begat the FDA trials process, the rest is history. Somehow they never understood they were in a death spiral, which BTW is what killed John Kennedy Jr. off Cape Cod.
So, let's all move on then. Precision Medicine-Science looks to me to be the next version of the Scientific Method...but...it now includes breaking through the walls of, "Not knowing what we don't know". Well, we are going to find out w/the help of some excellent new AI tools and with a process team who have challenged the establishment and (so far) are still alive. The PROCESS is what matters.
Your cup half empty philosophy is well known to members of the MB.
Thanks Biostockclub:
Xena, my suggestion, take a couple of days and do something else. We need you for the big game.
Yes, understand WS closed was curious about ROW (UK, FR, AUS, GER) etc. PR/news could come from anywhere in case of AVXL. It will not take much for a flashover IMO.
Will markets be open Monday, not including WS?
A classic post on what this (AVXL) is all about. When an otherwise healthy human has their life destroyed while they watch, what could be more devastating?
If everything we have been given to read/told about Anavex and A2-73 and if this turns out to be some kind of snake oil farce then so be it, but we will have done our DD.
IMO, we are witnessing a kind of medical development process asteroid strike on an established system which has been almost totally ineffective for years. Now experts predict the healthcare cost of AD w/in 30 years will be greater than U.S.DOD projected budget. So, if destroying lives is not sufficient motivation then maybe projected costs will be.
I have recently begun to consider that FDA/other BP/government leadership has been holding back. They cannot be so incompetent as to not see the importance of CNS diseases-treatment. Is status quo acceptable as long as the erevrgreen bills get paid?
Something is not right, there are/have been snake oil events for sure but AVXL is not one of them. Someone needs their ass kicked.
I would imagine the fact that they are also still breathing should help. Add to that, no brain bleed, sleeping OK and few other basic self care things. People will notice theses things. On the downside they do not get a chance to meet a lot of new people every day.
Not at all shabby. There has to be a pony in here somewhere.
Xena
AVXL from down under rally is likely based on past performance. On the other hand, the best team that money can buy, NYY has been all but statistically eliminated. Maybe the NYG will do well....yeah right.
SOKOL says:
OK, we'll see I guess. Lots of guidance written on this kind of obvious issue by FDA.
Bourbon:
f1ash...all very good points. Yes, we will need to hit a lottery or make moves to achieve the goals. I am hoping he can sequence actions/results to minimize the impact.
powerwalker, thanks. Yes, it reads better. The structural sequences and (shall/may) delivery is till inconsistent w/today's needs and technological capability/style. Overall, if sponsors must wait they are going to be looking elsewhere. IMO, if AVXL gets results by going a different path the FDA will have to adapt instead of insisting that everyone else follow them. IMO.
Kentucky123. Your observation makes good sense. It s possible to get too close. I am planning to buy more here.
ihidfromtheX...honor to meet you. I think you are right, others may take time to see. http://defense-arts-center.com/articles/2016/2/22/karate-ni-sente-nashi
Another one (CNS Disease pfizer) bites the dust.
https://finance.yahoo.com/m/4100621f-94f6-3abe-ba1a-b4f4b494c9e5/ss_pfizer-stops-developing.html
Any thoughts, clues, explanations on why AVXL sp continues to waffle-edge downward or what ever the technical term is for what we have seen since last trial start PR? I am open to rational conspiracy theories as explanation. SP seems to have no correlation with potential of product plans or healthcare system need. A2-73 is at least as viable AD option as BIIB's.
BTW, if it is due to some shadow competitor effect please provide evidence.
Thanks Kevli33: Dr.G. says ...I have broken the code below.
dia76ca
Extreme said..
Is it OK-rational to HATE a color? Red is a really lousy color.
Powerwalker, thanks for the link and information. I remain baffled by the BIIB AD product development efforts. The management seems to have a blind spot around the Amyloid thesis long history of failures. Yes, they have a lot of money to throw around so their campaign seemingly stretches over the horizon. I get the sense there is some kind of silent showdown w/AVXL being played out. Anyone who holds BIIB stock should be paying attention.