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Science 2/17/ 2021 Intranasal fusion inhibitory lipopeptide prevents direct contact SARS CoV 2 transmission in ferrets. Again, that should be Brilacidin.
But it ain't.
Instead we will treat already hospitalized inpatients - a very sick group, mind you. With most of the trial taking place in a country no one trusts. Russia. Seriously? So what if the science is good? Who trusts the Russians?
Totally bonkers the way this unfolded. Sure I get it: we had no equivalent lung inhaler to budesonide, so we could not test it. And we have no intranasal inhaler similar to the ferret drug to test either. No drug company apparently willing to help out little IP and B to warp speed the development of these delivery systems.
And so we have ended up in a weird place for sure.
Molodetz(strong work) maxinvest! This is one of the most bizarre developments here ever. How to figure it? Trial was supposed to be 160 and they say 106 here- a misprint? Numbers reversed? 54 patients for the US? Why? That'd be exactly 2/3 there and 1/3 here. This will make conclusions harder and not easier for us shareholders. When Russia says what its vaccine results are, do you believe them? Of course not. No one trusts the Russians about anything.
For IP to run 2/3 of its trial through Russia is a mistake, unless this was forced on IP and B as part of a partnership. Is that the next announcement?
This is too weird. The trial started in Russia and no one bothers to inform the shareholders.
Nivozmozhno(unbelievable)
why just one week? why not one month? That means they have been working secretly on those big grants for several months too, right?
LOL
Oh- and I wonder how far along they are with B UC and B OM already?
Just cannot make this stuff up
Just another day with no trial and no info from the company. Business as usual lost in the chatter about Russia. Will the trial even start?
How does partnership at this point make any sense? If B works, better for IP to control it until results are out and the company is worth much much more. No one signed up over the summer and fall to help get the lab stuff go smoother and faster and to get the trial started. Why now? The time a big partner woulda helped was May and June, so that we coulda had data back and a trial start in August or Sept. But no. Despite all that hype by Leo- so much interest shown-no one stepped up and things moved on non warp speed....
If the trial fails then that is the end of B v C and maybe the end of IP too
Don't you think it is already going on? here and in Russia? Less info is more.
Leo=perfect CEO to fail to inform
Leo=ideal CEO to keep shareholders in the dark
IMHO they are hard at work on the unannounced grants already, and the trial must be what- almost through recruiting.
Keep it quiet Leo!
Oh so quiet
Favipiravir? Hindsight? remember that name? Pls see Bakovics Viruses 2/9/21 paper pages 8 and 9. Of course also in the preprint too, remember? With a statement that B and F both had antiviral activity but no synergy.
That was the conclusion - in the lab: no synergy.
I started looking up RX of C in Russia and see that they use avipiravir/favipiravir, how frequently I do not know yet. Interesting that the lab chose Remdesivir and Favipiravir. Were they considering Russia way back then? Although favip originally Japanese drug.
Opyat, pochemoo Rossiya?
Again, why Russia???
Trust- that is what it is all about. If the Russia data is good and USA indeterminate I can assure you that B v C is dead. Would anyone suggest otherwise?
still no trial start..no details ...nichivo(I have no Cyrillic keyboard)
Time passes, IP fails to get B into the ring v C.
Interesting prediction of Russia as trial site so long ago-
just a lucky guess one supposes....mozhet bweet(Cyrillic problem again)
Best case for obfuscation! What if data are not just so, perfectly in alignment? Who would ever trust data out of Russia? Nobody, right? If trial results are not so good here and better there what will Leo say? I can tell you this- he can say all he wants to, put out all the twisted stats he wants and it will not matter one whit- B will sit on the shelf and not move forward here.
It'll be like that B OM "success." You know, the failure that everyone pretends was a success- even though there was no deal, no P3 no nothing.
If there is good Russian data and not so good USA data B for C is a goner.
Why oh why choose Russia? Different standard of care? They must get Dexamethasone there since it is very very cheap. I do not know if they use Remdesivir or not.
The Russia choice makes me very uneasy
please please please not trial announcement today or the next or the next and just run the trial, it's already going. Tell people when it is over when it works. Or, do shareholders even need to know then? Maybe just keep it all vey quiet for a long time and that is the best strategy. Less news=more!
That strategy has done so well for IP. Just look at the grant! They are bound to be working on all sorts of viruses with grants including MERS and SARS but- by not telling about it we can all still accumulate at these low prices.
Just keep trial and grant news quiet and then spring it on everyone- at a later date. Things are just bound to be up and running. Not only is the trial running, heck, they may be almost finished with the trial. But no news is good news.
No news is good news, can't you see?
Leo=ideal CEO=less communication is more!
ugly ugly ugly as the CEO tells company owners= shareholders nothing at all about the trial delay. So what is the story Mr Ehrlich? Your shareholders deserve no info NO INFO???
is this bogus or what?
Untruth teller. Momentum squanderer. Fool's gold peddler.
Lemming leader. Deliverance misser.
IP CEO=loser in so many important ways.
Who got him to try B as an antiviral? Who?
DeG?
The whole endeavor has been a fiasco with horribly slow research over the summer and fall and here we are: trial talk for ALMOST AN ENTIRE YEAR PEOPLE!
Trial talk PR starts April 6 and where are we? No trial started, IP disgraced with the missed announcements, CEO worthless nonsense PRs on so many fronts too sad for words....
the trial- when is it, anyway? Oh yeah, we keep hearing that it will start but NO! Is this just all a bit embarrassing? Of course it is.
Get in the game Leo
Tell your shareholders what the problems are Leo
Do not make a total fool of yourself and the company- as you have done recently.
Ugh
it has been his whole career, no big deal , nothing new, sorry. much ado about nothing
wait for the trial, already
embarrassing and pathetic to own this company- the CEO will not provide essential info. Why not?
now moving from urgency to emergency-
what is up with the trial? Why no communication from IP? Do company owners=us deserve to know? Leo will not say so the 13 cent shares can be dumped now before a problem?
Why not sell those shares when there is a trial announcement bump?
I guess we sit facing the corner, while the potential cases to treat dwindle.
A couple more million vaccinated every day. How will the vaccines do against the variants?
Leo would have appeared to squandered our opportunity
Three months ago woulda been a very good time to finish the trial But no-
b-inhaler? sure they can get in line behind the other b inhaler for c, budesonide? The drug and delivery with some actual human experience.
IP misses out. They actually really need those trials on MERS or SARS to prove wider possible efficacy. I suppose it all comes down to this trial and if it fails no one would bother with B and other corona viruses
inflammable means flammable? What a country! A great Dr Nick line-
What would Homer have to say about trial mispronouncements? D'oh.
if the trial does not start today then what to say and what to do?
Oh yeah- they already started it... now THAT is really funny-
Ha- you do not need me then. For amusement please let me refer you to the B OM subset PRs from spring 2019. That's a laugh.
Or, what about the recent 3 strikes for IP announcing the trial? Comedy, certainly, heading for tragedy if the trial never starts.
Can Leo finally start the trial? After striking out, 3 misses, with the announcement? Inquiring minds want to know what'll happen this week. We just endured pathetic lack of info flow from the company last week.
Can IP get in the game?
Leo's lemmings wanna know. We all wanna know
Just so you know folks- you can read the numbers. But from the from lines of Mass- and I am not talking about anywhere else. Almost nobody with COVID coming through the ED as opposed to everybody with COVID a month ago.
Leo? You starting the trial soon?
I sure hope so. Just try to announce it correctly for a change.
OK?
of course somebody- lots of people -will need antiviral therapy
BUT the market for B is less than it was, likely by many thousands of doses, due to failure of IP to launch the trial(if it even works)and then to start treatment 3 months ago
and what about the day after? and the day after that? Or a couple days ago?
same coulda been said every day for 3 months already...
Leo can no longer announce that the trial will start- he can only announce that it did start.
If you screw up an announcement 3 x already you thehave to change things up. You cannot keep repeating the same thing if you get it wrong again and again and again.
I mean, who's stupid enough to believe him if he says it will start (fill in the blank). No one is that dumb.
Or are they? I wonder...
and what about P?? The trinity? B and K and P? Can't they bring that back too?
I feel the power of B in a lab in Virginia but wonder about how things will go in hospitalized COVID patients.
That is, if the trial ever starts.
Any day now right?
Any day now for the last 3 months.....
is this sad, or what?
Please remember : info is for losers! Leo already started the trial and got the grant and MERS and SARS are on the run in the GMU ! Tell no one! Since when do shareholders have to be informed of material events??!!
Baby B for C, baby
B for C, baby
Baby will it ever B?
Hey Leo- guess what. You need to tell us what's goin' on-
Will there actually be B v C trial? So much talk about it and yet it has not begun. I am not saying there will be no trial but it is appropriate to ask if there is a problem that Leo will not explain since he has said it would start 3x already- and no trial yet
Here endeth one of the saddest weeks in IP history. Not only did the trial not start- as has been announced 3 times now-as we reach midFeb, but the CEO never bothered to explain the delay.
This sort of failure to communicate is typical of Mr Ehrlich and is deplorable.
What a screwup.
you do not mean it, do you? are you saying that people want to know the results in the B v C trial before they can accurately assess the value of the company or a partnership?
People just do not want to commit. Sad, no?
I mean: know what you own.
We don't need no stinking trial to know what we own. Do we?
LOL
I bet you are right. After all, how many times can he be wrong about the trial starting? Once or twice?
umm, yes.
Wrong three times?
Umm, yes.
More than three times(gulp)?
Probably not.
Eventually he has to say something. Just not on any reasonable time frame, is all.
I much prefer believing that all is well and that the trial did start- recruitment even as we speak. And that we got the grant and that there is ongoing research on B vs MERS etc. And that B v UC will start as planned too.
No need whatsoever to tell anyone about any of it. The need to know is for the weak hands that oughta sell.
More information is for losers.
superb summary not to mention April 6 2020 PR which says that discussions are beginning for a trial of B v C. So much talk about a trial and never any actual start. All talk.
And not only did the trial probably start, IP probably got the grant too, to study other viruses. We never heard otherwise, right? And why should Leo tell anybody- keep the doubters on their toes!
Maybe he started B OM 3 and B UC oral trials too.
But he just is not saying because IP is so crazy like a fox.
I agree- run the company and move it forward and never tell anyone about it.
Until you finally do tell someone.
I wonder when that will be?
gee, I wonder why we even have to bother with a B for C trial? I mean, just look at those data for completely unrelated problems- cellulitis and distal ulcerative colitis? But we still have to prove B can help C patients?
Who could possibly suggest that Remdesivir would be great in the lab and so- so in real life? Oh- that has already been shown?
Hmm. OK we do need atrial, then.
Just start it up please Leo
Hey-it already started...
LOL
No really, it's going on right now.
Please: wake up already
shocking dereliction of duty to fail to inform shareholders of trial delay. What is happening? Why the delay? It would not be so worrisome if Leo had no track record of failing to update shareholders about problems. But of course he does.
Recent update problems? Remember the grants people? The ones for all the viruses that B was going to work against? And then the MERS SARS testing?
We hear so little about grants these days.
Like nothing. All that chatter from the CEO and then silence.
Put up or shut up IP
please contact CEO to demand answers. This is shocking-
write your CEO to demand explanation for failure to inform company owners-us-about the trial.
Pathetic. This is getting worse as each day passes