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You who have not received a proxy to vote email message. It is possible that you have not selected that option to receive such info on your stocks online with your broker? Check into your broker online and find the place to do so. And or call them and ask where your proxy is. My Etrade accounts sent it out one day last week. Easy grab the control number in the Email click link insert control number. Read the questions and vote for each of them. I voted WITH the the Board of Directors suggestion. YES on all questions. Hit the go button and shortly you receive an email for your verification of your votes.
John k9uwa
Redwing and any others contemplating your votes. PLEASE PLEASE PLEASE DO VOTE. And yes like many other have or will respond I voted YES in accordance with the Directors Wishes. This is a MOST important vote for our shares.
Thanks
John k9uwa
LEO Xena and others Date of Record for VOTING your shares is just the settlement date by SEC 3 business days back from probably the Board Meeting date when the VOTE will actually take place. Or in SEC terms "trade date plus three days". OR perhaps since the Proxy's came out in the last couple days was the record date for ownership of shares that are allowed to vote? I guess I can't answer that question. Think about this, I do some trade shares sometimes as much as 20% or so above my core position. So Yesterday I bought my trade shares back as I had sold them on Friday. Yeah 50 cents cheaper gets me more shares this time around. So the question becomes the Proxy I Voted yesterday was prior to my repurchase of the trade shares. And I might sell them in a few days or maybe never. Two points here. First I just brought up again the Proxy Vote and I can still change my vote if I want to do so. Second point. The Proxy Vote doesn't list the number of shares that I own in that account. It does state that Annual meeting is 2017 Tuesday, April 18, 2017. So I am guessing that RECORD DATE TO VOTE has to be T+3 business days PRIOR TO the actual meeting date. That is the date to VOTE your shares and who owns them as of T+3 days prior to meeting April 18th.
Now then POISON PILL RECORD DATE. Assumes that the provision is voted IN at the Annual Meeting. RECORD DATE for POISON Pill SHARES will go to those who had OWNERSHIP on Feb 17, 2017. Meaning shares you owned T+3 days prior to Feb 17th. Even if you SOLD those shares today or if some company made a hostile offer of 50 bucks or so and bought over 50% of the outstanding shares. including yes you sold your shares. YOU STILL HAVE THE RIGHT to those additional shares as per the poison pill arrangement.
Or I am all screwed up and will someone else explain where I am wrong?
Xena and others as to confidence in voting etc. I have to have confidence in Etrade my Broker. Or else I probably should leave them in favor of some other brokerage firm.
My OTC shares I had prior to the RSS and becoming NASDAQ were all converted to NSADAQ shares by Etrade ... Yes Etrade can be sometimes called E-TARD as it many times takes them a few days longer than other brokerages to get it all done and into our accounts correctly. Like when Opko Health gobbled up Prolor Israeli Company and someone messed up the paperwork. It took I think a couple weeks before my Prolor shares became Opko shares.
Now if one held OTC shares the real paper in your hand for the shares rather than being held ... in Street Name I think is the terminology. Sorry calling on my 40 years ago NASD training. Memory sucks sometimes. If one held the real paper shares then probably you would have to deal direct with the company to vote those shares.
Anyway please correct me and the others who read this board if I am wrong.
John k9uwa
Xena I received my proxy yesterday morning from Etrade. I voted both accounts and within a few minutes received confirmation of the votes. I have been an Etrade customer for about 15 years. Over that time I have received MANY of these proxy ballots. Always they are correctly registered and legit. Sorry, I wouldn't trust someone who called on the phone. It may well be legit if they already had your account and share info and phone number.
Whatever you people do .. be SURE TO VOTE .
John k9uwa
Excellent Article. Thanks Turnaround for posting the link. It looks like Anavex is doing well today considering the beating of the rest of the Bio section. I am happy. Bought back my Trade Shares at 5.51 Thanks Tom for your charts and key pricing points. I see it bounced off 5.50 nicely today.
John k9uwa
Thank You Tom for your charts. Last trade shares bought 5.51 sold 6.01 yesterday. Bought back trade shares a while ago at same 5.51. Now watching them all go back up. All the while the core position is all long term much of it pre-RSS. Whole market beat up today gave added ability to the manipulators.
Quite Happy I am.
John k9uwa
Yes time to beat the manipulators again at their old game. Still holding my core position. Most is pre-RSS. Bought trade shares at 5.51 a week ago. Sold trade shares yesterday 6.01. Hoping to buy them back at 5.51 again. Getting close.
John k9uwa
Proxy Voting came from Etrade this morning.
John k9uwa
So when will Dr Missling blow the doors off? Asia? West Coast? Oppenhiemer? Annual Stockholders Meeting? The Oppenheimer presentation has Online Live Real Time Web access. Where the Conferences don't offer RealTime to any who have interest.
John k9uwa
Dear OFP the 57 week has to do with the initial 5 week Wash Out Period at the beginning of the test. Thats On and Off and On and Off definition of Wash Out Period. So get over that 57 week number. It is 52 weeks of being ON THE DRUG plus the first 5 weeks.
As to Placebo in the case of Alzheimer's The world already has lots of Placebo Tests of these patients. Over a years time they ALL decline in cognitive response.
Perhaps you and many others have never been around Dementia and Alzheimer's patients for any consistent long period of time? I had unfortunately. All of these patients will exhibit "Good and Bad" days. Some days you would think there is nothing wrong with them. And the next day they are mentally out in space someplace. But over a period of TIME. They all decline.
As to this other company with some short term test for Alzheimers I wouldn't believe any of their results. Unless they had started with patients who had 20 score MMSE and 100% of them all went to 30 MMSE score after this short 3 month test. Then I might think that they did have some real cure.
John k9uwa
"break out the super-responders by correlative sub group in the 12-month results and is not making claims to any empirical legitimate stratification. "
Yes they did. I have the chart in a PDF file but don't know how to post it here. Sometimes ago I think Xena did post the chart.
MMSE scores of the 6 super responders. Covers 57 weeks.
2 started at MMSE of 25 1 ended at 29 the other ended at 28
1 started at 22 and ended at 24
3 started at 20 1 of them ended at 26 another at 25 and the last one at 22.
The fact that ANYONE with Alzheimer increased MMSE over 57 weeks is just flat out amazing. The Average Decline is 1.65 pts per year. No one increases.
John k9uwa
"I'm interested to see the updated institutional ownership. I think it will surprise some"
Institutions have to file quarterly. 45 days after the close of the quarter. So the next batch we will see on May 15th. 45 days after March 30th.
All we have now are the Dec 31 2016 13F filings. 18%. End of previous Qtr it was 12% ended Sept30 2016 filed by Nov 15th.
Whoever Park West is they were not listed at all for the qtr ending last Sept. Their brand new entry as of Dec 31 was 1.5M shares. Someone is buying for sure.
To: Bourbon on my Cornflakes. It is the same info on https://fintel.io/so/us/avxl Fintel shows the same basic numbers for institutions. All of them get it from the same source. SEC 13F forms and their auto programs sort the info into easy to read for all of us.
I am with Whiskey Sausage in thinking that solid retail is at least in the 20% range. Many of the posters here I recognize from back in the old Yahoo board days. Prior to the Reverse Split dates.
GLTA have a nice weekend.
John k9uwa
From WhiskeySausage
Nice. Add to that the estimated 10-15% retail (from FB and this board) and it will be difficult for a hostile takeover of any sort.
Interesting when I was wandering through the 70 Institutions who filed 13F forms as of 12/31/2016. Source Whale Wisdom. I am in 47th place with my meager holdings. That doesn't include my trade shares just the core position.
As to Hostile Takeover at about $100 pps I would consider selling to some hostile takeover offer!
Wondering if one of Tom's "Stink Bids" made it today? $5.21 I think was about the low for today. I offed my trade shares early this morning for +1% today and bought them back a while later for -1% today.
A good Weekend to all.
John k9uwa
Well yes, I too would be much happier if the pps were up considerably from the present price. However I did make money on Anavex in 2016. By playing the trades shares game Always maintaining my core position as the long term goal or Anavex. But at the same time buying dips and selling the trade shares on the peaks. Yeah not really on the peak. I usually never manage to hit the real peaks. Enough of those trades and I am up nicely in 2016. Hoping of course that 2017 will be a banner year.
John k9uwa
And I hope that in 2017 Dr Missling makes 100 million dollars. Note majority of his compensation is based on milestones and share price. Doc makes money we all do. Excellent.
John k9uwa
"Market Manipulation again this morning" NICE. I beat them at their own GAME. Sold yesterdays trade shares at +3% and bought them back at -2%. Screw'em the Market Makers Platoes of Wall St. Main position they can have it when Dr Missling sells his shares.
John k9uwa
"keep your shares under your pillowcase"
More Fun to buy a few trade shares. My limit order at $5.51 I did get a partial fill of the order before it started walking back up.
John k9uwa
"Wow! They're really trying hard to shake those shares
loose. "
And the Walk down always seem to cease when I and I am sure others step in buying a few "Trade Shares".
John k9uwa
"Great post .. Motley Fool must be SHORT sighted to continue to dump on Anavex.. "
And what really Pee's Me off over Motley Fool is they don't allow any comments to be made to their articles. So out of all the readers that read their garbage articles just how many of them are going to bother to do any DD ?... ZERO is my guess. Even here on this Anavex board look at the number of people who show up and ask questions about everything you can think of. Financing being always the Biggie. Personally I really like the latest "Poison Pill" method that Dr Missling has setup. And he has continually stated that yes when it comes time we will partner with big Pharma for distribution and marketing. When that time comes I am sure that Dr Missling will have our interests upmost in his mind. Don't forget his own shares are his real payoff for doing his job. As to the partnering bit I have watched some other Bio Drug deals happen. One doesn't have to offer that partner the whole World. Just parts of it. Keeping other parts totally for the Bio that produced the drug.
Look at the changes in the FDA Cures Act etc. Missling made three trips to DC involved with writing some parts of the Adaptive Trial and other parts of this stuff. Ya don't think that the Powers to be selected him because they liked his haircut do you?
Our Day Will Come.
John k9uwa
"How much will the Aussie grant be for, approximately?"
I don't know that an exact amount was specified. You will have to go read the Annual Report from Caulfield Research hospital. That is where it was mentioned. Common sense says that since the last phase test went well that the Aussies would continue to pay the bill. It is to their benefit to do so when you think of the tremendous costs of dealing with the Alzheimers patients they have and will have in their health system.
Also Dr Missling when asked in some interview a month or so back stated we have enough cash for two years. That was just after he mentioned all three tests. Rett, Parkinson, Alzheimer.
https://www.alfredhealth.org.au/caulfield
If I had to make a guess regarding the previous and ongoing tests at Caulfield I would say that Anavex provided the drug. And most likely the costs of the evaluation of the results. The rest was probably all paid by Caulfield and the AU Govt.
As to the naysayers regarding No Placebo in the testing group. I would say that ZERO NADA NoOne who has Alzheimer will go a year plus without a reduction in cognitive ability.
My own personal experience. My own Mother had Alzheimer the same as three generations of all Females born of a Female in my Mothers Family. None of the Males have ever had it. When my Mother got to the point of not being able to live in her home with just a daycare caretaker we moved her into our home for her last 19 months of life. Full time caretaker plus my wife and myself. The last 9 months I also was retired and there all the time as well. Mother was mentally as sharp as a tack until her last 2.5 years. The last year it was sometimes I was ME, Sometimes I was my Father who had passed away 10+ years prior. And sometimes I was that "THING" that was married to my wife. So I have been there and got the Tee Shirt as they say.
John k9uwa
" Simple question. Where will the monies come from for the Ph 3 trials. Cash on hand "and" remaining Lincoln park option
will be tapped out in another 2 qtrs. "
The Rett Test financed through a Grant from rettsyndrome.org
The Parkinsons test financed by a grant from the Michael J Fox organization
And the alzheimers test financed by the Australian Government.
Any more questions?
John k9uwa
Perhaps arrilathehunt has hit on something here.
The CNBC app has our institutional ownership at 20.82%. Want last count at 18.5%?
Yes from NASDAQ it was and is at Institutional Ownership 18.26% Total Shares Outstanding (millions) 41
where CNBC has Total Number of Shares Held 10.9M
% Change in Ownership -1% % Shares Owned 21%
Notice that Nasdaq shows only totals filed in 13F forms Dec 31 2016
Institution Nasdaq CNBC
PARK WEST 1,500,000 2.1M
VANGUARD 1,314,104 1.3M
BLACKROCK 1,057,856 1.3M
MISSLING 1.0M
Lets stop here for a bit. Vanguard and Blackrock have more than one fund showing in the NASDAQ listings. Probably the added together makes them the same on both NASDAQ and CNBC ? However MISSLING is listed at 1M shares in the CNBC 20.82% yes Missling is not listed with the NASDAQ totals.
The other interesting part of the above is Park West at 2.1M vs 1.5M so does CNBC update with current ownership? or do they only do it once per quarter as does NASDAQ ???
We should watch to see it Park West totals show differently in the next couple weeks.
John k9uwa
I as well appreciate your charts Tom. They can call me whatever they want to call me. First yes I own a considerable amount of this stock and have held it since prior to the reverse split days. I also keep around 30% or so in Cash and with that I buy "Trade Shares" Of this and a couple others I own. If I happen to buy at the wrong time no big deal I just keep the trade shares until the price is again above my basis.
Lots of fun watching this company. Quite interesting that Doc Missling has been moved from just a presenter over to this Forum. Or maybe he does a presentation plus forum and skips the poster part. It certainly seems that Doc is in demand.
And Tom they call that Key word advertising. Amazing the prices they pay for that stuff. My little old website has keyword ads. Last year the keyword income paid the bill for at least 10 years of what the whole website costs me.
John k9uwa
http://johnjeanantiqueradio.com/
re: AU Govt paying the bill for the upcoming tests. THEY never did state that the Govt was paying the bill for the last tests. The only place you could find it or figure it out was from some of the Caulfield annual statements. Anavex certainly didn't pay it as their cash never dropped by any significant amount during the tests. So I also doubt you find anything in print that says AU Govt is again paying the bills.
As to this latest re: additional shares etc. See Whiskey Sausages description. He hit the nail right on the head. Missling can continue to give the bird to cheap bids to buy Anavex. The Good Doctor has the shareholders best interest. Same as his own. PPS way up and for him over time additional shares as part of his compensation.
John k9uwa
It certainly looks that way. 290K shares and we are up better than 2%. Not many interested in selling unless they get more for their shares.
Several additional 13F forms filed in the last 3 days showing total new Tutes and or increases. Today being last day to file. In the last week Tutes jumped from 12% up to 18% ownership. Also don't forget this is from Qtr ending 12/31/2016 which is only the third quarter that we have been Nasdaq and no long OTC. It seems the cat is out of the bag.
John k9uwa
"It has been demonstrated that the placebo effect in Alzheimer's studies wears out after 12 weeks. We are 2 years into the Anavex study and people are still getting better. Explain that to us."
Alzheimers patients over 1 year and approaching 2 years in 2-73 tests are only going to be doing one thing. Reduced MMSE scores. Any patients who held their own or increased their scores are only have one reason. The 2-73 drug WORKS.
So my question is the extension given to these patients. Did Anavex change the quantity of the drug and or the combination with DZP? Misslings comment that the patients on the low level were holding their own on scores. SUPER would be if they increase these patients to the level of the super responder group. Yes all OK to start another larger group including the placebo group. But it is an Adaptive Test. So Adapt.
Awaiting the 15Mo results of tests!
John k9uwa
I trust Dr Missling to get us a great deal. He himself stands to gain a large amount if the stock goes way up or produces some large form of income.
John k9uwa
I would accept 10B PLUS 50% of the GROSS sales for any use of 2-73. And of course an arrangement for considerably more if 3-71 is better.
That would be much better than an outright total sale of the company.
John k9uwa
That's not what I heard Tom. Pretty sure Xena is correct. Or else my ears heard something different than you heard. Doc didn't make any specific comments as to WHO was financing the Parkinsons and the ALZ trial. But thought he said financing was provided to Anavex.
We can probably surmise the WHO. Most likely the Parkinson's is from MJF and ALZ is from the Australian Government + Caulfield Research Hospital.
John k9uwa
It seems pretty clear to me. This copied from THE PATENT
Publication number US9180106 B2
Publication type Grant
Application number US 14/205,637
Publication date Nov 10, 2015
Filing date Mar 12, 2014
Priority date Feb 26, 2009
Also published as CN102325529A, 4 More »
Inventors Alexandre Vamvakides
Original Assignee Anavex Life Sciences Corp.
Export Citation BiBTeX, EndNote, RefMan
Patent Citations (11), Classifications (28)
External Links: USPTO, USPTO Assignment, Espacenet
Looks like it was GRANTED on Nov 10, 2015.
NEW YORK, NY, August 12, 2015
Missling said: Anavex expects the patent to be issued by the end of 2015.
Appears he was correct.
Your comments about the 10K that 10K was dated prior to receiving or prior to the issue of the GRANTED PATENT date perhaps?
If you want google this and read all of it.
https://www.google.com/patents/US9180106
Jeez if you hit the 4 more button they also issued it in Chinese. Translated. I would think this should put it to rest for anyone who can read. PATENT HAS BEEN ISSUED AND GRANTED.
John k9uwa
"Most institutions have guidelines of not investing in a startup biotech until its drug is, at least, into Phase 3 "
Tell that to the 1,000,000 additional shares purchased during the last quarter to these Institutions.
yes that list is a Net increase of 1M shares.
https://fintel.io/so/us/avxl
Current total of the institution list is 4.66 M shares. So the 1M increase this last quarter is a significant percentage increase.
John k9uwa
RE "Another insty added 500 shares"
I see many institutions in the list who added shares this last quarter and only a very few who reduced shares. Many new Institutions in the list as well.
AND Tortoise Investment Management, LLC 250 250 still holding slow and steady.
Nice bit of information today
John k9uwa
The thoughts about the Tutes holding stocks are that #1 they have analyst types who decide what stocks to buy and what to sell and supposedly those people know more about what to select and what to sell than us "Joe Public" types. #2 Tutes usually don't invest for a short period of time. As to the small position holding Tutes at 5000 shares Jeez I own considerably more than that amount.
John k9uwa
McMagyar your comment: "You are aware of the Placeholder poster title and outline for AD/PK conference on 3-31 right ? It confirms 15 Month success!"
Can you tell me where you found this Placeholder Poster?
Thanks
John k9uwa
XenaLives sorry for the misunderstanding of my comments.
Many of my Australian Amateur Radio friends refer to themselves as living in the land of OZ.
Explanation is: An informal reference to a resident of Australia is "Aussie," and an informal reference to the country itself is an even shorter derivative of the word, "Aus." When residents pronounce "Aus" with a hissing "s" sound, it sounds like "Oz," which has resulted in the country's informal nickname of "Oz."
Most likely the cost will be borne by the research hospital. Minimal costs to Anavex. They supply the pills. All other costs paid by someone else. Dr Missling is doing just fine in my opinion.
I have only been in AVXL since it was 55 to 80 cents pps.
John k9uwa
Perhaps the Research Hospitals in OZ land aren't charging Anavex for the trials tests etc? Perhaps the only charge to Anavex is to supply the pills used?
Regardless Missling said these are the upcoming tests we will preform. And we have the cash for 2 years. Seems pretty clear to me regardless of the money sources needed.
John k9uwa
Good Post Tom. And you know that two can play that game. I do play it in the reverse of the shorties. When they drive it down I buy additional shares. What I call Trade Shares. When it bounces up enough I might sell the trade shares. Nothing says I have to sell them. I don't pay any interest like shorty pays. I don't need the money for something else. A few dimes here and there pps and I am in cheaper than my original. Original was back in the 65 to 75 cent range prior to RRS date. Not sure where I am at presently but for sure core position has a real net cost of considerably less than my original purchases. I did grab some the other day at $3.91.
Makes for something to do while waiting on the big one one of these days.
John k9uwa
don't you think that those patients and their caregivers don't talk to each other when they are in for their periodic testing? Over a period of time those people knew that some were improving more than others. They were smart enough to figure out who and why. Once their time period of testing was up it was Their Choice whether to continue or not continue on a voluntary basis. All selected yes to continue. At that point it would have been their voluntary right to no longer take the other stuff. Seems pretty simple to me. Also one of our mathematicians did the calculations showing the added 5 weeks 57 rather than 52. Something sure has hell changed at that point. Or maybe you just think it was dumb luck?
Look up Miss Australia and reread her 100 and some posts over the last year or so.
John k9uwa
Only conjecture on my part but. I think that the FDA has as much information as Anavex has. Keep in mind that some patients are nearing two years on 2-73. Some patients went from combo to Mono someplace along the way in the last year of testing. Having all this additional information the FDA will design he P3 the way they want it. Anavex will do the trial as directed by FDA. End of Story.
John k9uwa
Did someone say Japanese Company? Hummmm makes one wonder doesn't it.
From Wikipedia: Mizuho Securities Co., Ltd. is a Japanese investment banking and securities firm. It is a subsidiary of Mizuho Corporate Bank, Ltd., which is a wholly owned subsidiary of Mizuho Financial Group, the second-biggest Japanese financial services conglomerate
John k9uwa