Register for free to join our community of investors and share your ideas. You will also get access to streaming quotes, interactive charts, trades, portfolio, live options flow and more tools.
Register for free to join our community of investors and share your ideas. You will also get access to streaming quotes, interactive charts, trades, portfolio, live options flow and more tools.
goodietime,
"This was 'The Plan', IT DID NOT WORK !!!!
Equity IS part of the plan NOW."
Very true! And this might explain why many peeps around here are so obsessed with telling everybody that escrows will see nothing. They have fallen into a trap by thinking that "normally" equity is kicked out of the game. But not in this case
Christine Ichims Poster:
http://stemcellmeetingonthemesa.com/scientific-symposium/poster-session/
15. Silencing of the Novel Leukemia Target NR2F6 Using DiffronC siRNA Technology Induces Terminal Differentiation of Murine Hematopoietic Stem & Progenitor Cells
Presented by: Christine Ichim, Regen BioPharma
Authors: Ichim, Christine (Regen BioPharma); Dervovic, Dzana (University of Toronto); Chesney, Alden (Sunnybrook Health Sciences Centre); Reis, Marciano (Sunnybrook Health Sciences Centre); Ichim, Thomas (Regen BioPharma); Koos, David (Regen BioPharma); Wells, Richard (Regen BioPharma)
Abstract:
To identify therapeutic targets, we previously adopted a novel single-cell approach that used microarray analysis of clonal siblings to identify the molecular signature of leukemia stem cells. Our work led to the discovery of the orphan nuclear receptor NR2F6 (EAR-2) as a potential leukemia stem cell therapeutic target. Previously we showed that NR2F6 is expressed greater in individual leukemia cells with clonogenic capacity than in leukemia cells that do not divide. In vitro, overexpression of NR2F6 inhibits differentiation of cell lines and primary bone marrow cells. In vivo, overexpression of NR2F6 leads to a rapidly fatal leukemia that is preceded by expansion of the stem cell compartment, c-kit+, sca-1+, lineage- hematopoietic cells (KSL cells) in mice. The discovery of the role of NR2F6 in leukemogenesis and the induction of differentiation of leukemia cell lines following silencing of NR2F6 expression suggests that this is a logical therapeutic target for differentiation therapy using gene silencing technology. Hence, we wished to show proof-of-concept that silencing of NR2F6 using the DiffronC siRNA gene silencing technology in primary mouse hematopoietic stem and progenitor cells promoted terminal differentiation. Herein, we show that while silencing of NR2F6 did not significantly reduce the number of colony forming units, it did significantly increase colony size. We then showed that silencing of NR2F6 reduced the clonal longevity of bone marrow cells: In replating experiments we observed a significant decrease in secondary colonies in cells treated with NR2F6 shRNA. Furthermore, silencing of NR2F6 resulted in a drastic reduction in KSL cells after six days of ex vivo culture, and caused a dramatic decline in lineage negative cells, and a concurrent increase in cells expressing the myeloid markers CD11b and Gr-1, suggesting that they had differentiated into cells of the neutrophil lineage. This was confirmed by examination of the cytomorphology of the bone marrow cultures. Taken together, these results establish that NR2F6 is a negative regulator of terminal differentiation of the hematopoietic lineage and lays the foundation for use of gene silencing technology against NR2F6 as differentiation therapy for diseases with blocked differentiation such as leukemia and myelodysplastic syndromes.
Key Words: cancer stem cell differentiation nuclear receptor gene silencing hematopoietic leukemia progenitor
Volume over 1.000.000 - Like!
Boris, thanks for sharing. Sounds interesting indeed
http://www.finanzen.ch/nachrichten/aktien/First-Data-Prices-IPO-At-$16-00-shr-1000859126
First Data Prices IPO At $16.00/shr
(RTTNews) - First Data announced the pricing of its initial public offering of 160 million shares of its Class A common stock at $16.00 per share. Shares of First Data's Class A common stock are expected to begin trading on the New York Stock Exchange on October 15, 2015 under the symbol "FDC," and the offering is expected to close on October 20, 2015, subject to customary closing conditions.
First Data has granted the underwriters a 30-day option to purchase up to an additional 24 million shares of its Class A common stock at the initial public offering price.
First Data noted that it will receive net proceeds of about $2.5 billion after deducting underwriting discounts and commissions and intends to use the net proceeds from the offering to redeem all $510 million aggregate principal amount of its 11.25% senior unsecured notes due 2021, approximately $1.6 billion aggregate principal amount of its 12.625% senior unsecured notes due 2021, and to pay applicable premiums and related fees and expenses, and for general corporate purposes.
Boris, Yes, I believe we are still in the game. Was surprised to read so much negative comments today without having a real base. Somethings up
100k shares@2.50$ were just bought
http://cdn1.boardpost.net/quote.php
$WMIH
That is possible! Just check the corresponding box on your settings page and it will do so
Set "Replies To Ignored People" on "hidden"
News on NASDAQ-Listing
http://ih.advfn.com/p.php?pid=nmona&article=68693336
Smug_rat, do you have experience with LEVEl2 on NASDAQ ? (I think that should be the "big cap pro" subscription?). Upgrading to that feature might be worth it for WMIH but I am actually not sure whether it is really useful. LEVEL2 on OTC was somewhat disappointing (share volume of MMs at Bid and Ask not fully shown etc.). Thanks, Kryo.
Justice, that sounds plausible and very promising. Even if it takes a few more days/weeks for an event to pop up, leaving OTC now and being upgraded to NASDAQ is a very good indicator for WMIHs future IMO
Thanks Justice! Great events ahead ??
There are many other great countries out there. You americans are really funny when it comes to the 4th of july
And can you provide any serious reason why they shouldn't be cashable?? Nonsense!
No, he made it fair & reasonable
No selloff in sight. Only the usual MM-games IMO
Very true so far
BBanBob: Remember the question was hypothetically
500$ per WAMPQ for 1/3 of my WAMPQ-escrows
If you can't take an intraday minus of 1,2% you probably shouldn't trade OTC-stocks. Relax dude, we will be fine soon ??
Same here. Wonder when will these shares go Live. In the meantime VNDM is taking RGBPdown again.
Didn´t we close at 0,20 yesterday ?? How come that actual 0,16 is shown as 0% in todays chart ?
No need to buy it back up. These little sells are only scare tactics. But these will not work here imo. RGBP may skyrocket soon based on positive news or fade away. I'll wait it out
Funny, somebody was really in need of a significant amount of money: 793 shares sold for 0,1011. I hope that guy has something really important to pay from these 80 Bucks, LOL
From PR: "We have essentially found a template (which needs to be refined) to make the small molecule chemical more potent, less toxic and more drug-like, which will allow us to create a therapy for cancer treatment."
Doesn´t sound like fluff to me.
BMSN$
Nice volume so far and 0,25s are up next. Might be an interesting week for RGBP with conference participation and maybe an update on the two INDs.
Yes agreed, it's pretty obvious what is going on. Even if there will be posted something in "2 hours", I am pretty sure that the more educated Board members here will clarify any "Proof" to be a misinterpretation. I will not stay up all night for this to happen, but will read the outcome tomorrow morning
How can "they be acknowledged" when you cannot distinct between PRE and POST-shareholders after the conversion to WMIH and Escrows.
Sorry, I am a non believer of that story
That was my understanding as well. Accepting the plan including giving releases entitled all shareholders to receive WMIH-shares and escrows, easy and simple. I wondered that this PRE vs. POST thing has revived
Mmh, as far as I remember, the ballot for POR7 was specific for the class of shares somebody had at that time. So e.g. we got ohne for commons and one for Ps, correct? These ballots asked for the number of shares owned at that Time, not when they were bought, correct? So I wonder how there could be something like a "Secret Marker" telling anyone that these shares were Pre- or Post-BK??
Just have a look at the boards intro page, it states:
"WMIH and WMILT iHub Message Board"
So a split between your points 1) and 2) is not necessary.
Concerning point 3) I don´t care, as I am not a US-citizen
Wrong! Not everyone got their divi yet, but the waiting goes on ...
Ok, thanks. Will have a closer look on that one.
So you have changed your Broker? I am comsidering that as well, as CC doesnt allow me to buy more
Yes, and starting tomorrow I will ride even better with my preferred shares from my initial divi shares )
GLTY, Kryo
It was Bid and Ask for BMAK IMO
Honestly, I have no clue, but I hope this is another piece of the puzzle, Koos and the Ichims are setting up for BMSN and RGBP
News (Amended Statement of ownership)
Cool_lion, you are spot on! Great analysis. Thank you for sharing this.
RGBP
Yes, but unfortunately I can't buy, my Broker has blocked everything ob OTC below 1 USD. Guess I'll have to wait for a higher PPS to increase my stack
Knight playing with himself
Next MM on the ask is over 0,42