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zip....
"I was advised today, by a lawyer, that some court cases, requiring juries, have been delayed."
No juries in the Amarin case..A bench trial....
I'm hoping we get the verdict next week or the following week...
":>) JL
Nice to see management acting intelligently and pro active...
There is no evidence that Vascepa will cut the risk of COVID-19..But IMO it is not far fetched that V could improve survival rates..The virus infection does trigger inflammatory storms which can injure vessel walls in an accelerated manner that has many of the effects seen in the aging process and in CVD...Logically V could be used in the active phase of the disease to mitigate the pneumonia and cardiac injuries which are really problems due to elevated SI...
":>) JL
Amarin Vascepa...
Quote (from the company): We will work to continue our diligent efforts to bring to healthcare professionals and the public our We will work to continue our diligent efforts to bring to healthcare professionals and the public our contribution to improved treatment of cardiovascular risk, which is not only an enormous and growing medical issue worldwide but also a leading factor of increased risk to those infected by COVID-19.”
Re: Facemasks....
You should wear a face mask if you are infected..The facemask is to protect those who you come into contact with, not yourself...
The contagion is not spread Airborne...It is spread by small droplets of saliva, sputum and other body fluids and stools..You touch a surface that is contaminated and then touch an area around your mouth, nose eyes ears or genitalia or anus...
Hence the importance of hand washing...The fact the endemic is not airborne is very important because it greatly decreases the chance of spreading...
":>) JL
jasbg....
Good point...
":>) JL
invest...
Quote: "at some time, during or after tha ANCHOR trial the FDA stated/ruled that triglycerides were not a valuable bio-marker for CVD risk." Can anybody point me to a link of that statement? "
Actually the FDA made their opinion very clear..by reneging on the ANCHOR SPA...The FDA cited three CVOTs..Those were ACCORD, AIM-HIGH and THRIVE...There was some evidence that trig lowering did result in CVD event risk..but it was not Stat SIG and lowering trigs had the effect elevating LDL-C...A surrogate, FDA did believe and recognise would increase CVD event risk.
The confusion comes about because elevated trigs (>150 mg/DL) does indicate a greater risk for CVD events...It's just that lowering trigs does not as a rule lower risks...The explanation lies in the fact that elevated Systemic Inflammation" (SI) actually increases trig levels...and elevated SI does increase the risk for CVD events..So trig lowering only lowers CVD event risk if the trig lowering is accomplished by lowering the SI...And this is why Vascepa (EPA) lowers trig and lowers CVD events because EPA lowers SI...
":>) JL
Babr...
Thanks for posting..I agree with you observations..They all add up to a very positive situation..
":>) Jl
S 4...
Don't forget about Chloroquine...I think it has a better chance of being a pandemic killer than GILD's drug...And it will be a hell of a lot cheaper..Even if it lacks the "Star Wars" appeal...
":>) JL
beach...
I would favor Co2 extraction rather than distillation..Distillation breaks down the molecular structure of EPA...and other eicosanoids..
":>) JL
Distillation is not good for these oils because distillation uses heat and heat denatures the fish oil components making them rancid and unusable physiologically...
Co2 separation uses vacuums and chromatography to do the separation which does not oxidise EPA...
":>) JL
Bouf...get lost....
Pelosi is not going anywhere..Trump did the right thing and the market loved it..They are being pro active..
":>) JL
@twi
I don't remember seeing any of those effects in the RVN..I wonder how many of those supposed effects were actually combat troops who were taking Chloroquine were using them to get out of country...
":>) JL
@twi...
Amazing that Chloroquine might work to stop the COVID-19 virus in its tracks. Chloroquine has been used for decades as a treatment for Falciparum Vivax a very potent strain of Malaria..It was used extensively in Vietnam and officers were graded on their soldiers adherence to taking the malaria drug...Getting Malaria was one way combat soldier could get out of Vietnam before their DEROS date..So many soldiers did not take their meds..
This is very big news..I did know about Chloroquine..But not exactly how it worked..Apparently as I understand it alters the PH (acidity) of certain membranes in the cell cytoplasm. Membranes which re required to synthesise the Viral proteins required for the viral structure...
IMO that makes it highly likely it will stop viral reproduction in human cells and is known to be safe from its long term history..The in Vivo trial should start right away...It should end the epidemic..They already know it works in cell culture...and clinically for malaria..
Plus the drug is taken in pill form and is dirt cheap...
":>) JL
In this case ...No..The generics know the story better than this certifiable Moron...I don't want him to get a stage on this MB...
":>) JL
ggwpq...
Why are you posting this moron bathroom installer's materials on this MB...The guy is a liar and a provocateur...Just a trouble maker...
":>) JL
Good news
Chinese using Gild's new RNA drug and chloriquine...A pill we used in Vietnam to cut the spread of Plasmodium Vivax...Both drugs look very promising in treating patients with COVID-19...
"In a three-page paper published Tuesday in Cell Research, scientists at the Wuhan Institute of Virology’s State Key Laboratory of Virology write that both chloroquine and the antiviral remdesivir were, individually, “highly effective” at inhibiting replication of the novel coronavirus in cell culture. Their drug screen evaluated five other drugs that were not effective. The authors could not be reached for comment."
Who says good news won't help Amarin...
":>) JL
PS..Because a drug is effective in cell culture does not mean it will work in Vivo...But the fact remdesivir and Cloroquine both proved effective in cell culture does mean they can cross the cell membrane and that is a biggie. Chloroquine is one of the most widely used drugs ever.
On another front the USA is gearing up testing for COVID-19..and this time the government is committed..Going to be anyone can go get tested.
":>) JL
Jas...
Course news will drive this buggy...News not only re: Amarin, but news we are getting a better understanding of COVID-19...Increased ability to estimate cases through testing which gives us a better idea of what is really happening..Possible new drugs like GILD's RNA drug..and if we get good news from Reno (and we should next week or the next)...
The dow futures are plus 1000..The sun is coming up off the ocean in Florida..I looks like its going to be a beautiful day..
":>) JL
Back2Deuce..
Please do not confuse KIWI with the facts...
":>) JL
KIWI..
Quote.. "After 1987, stocks took two years to top the levels seen Oct. 16, 1987"
A good deal of the recovery occurred early after the crash...
":>) JL
gg....
Its not that one person who is very active..can not spread the disease..The problem here is the Lawyer should have been contained. Quarantined..but being a lawyer he probably was arguing his rights...
In Saigon we had a 19 yo soldier who came into the Emergency Room. coughing...One of the nurse sent him home with a diagnosis of Hydrophobia, an archaic term for Rabies,..Rabies in the USA is very rare and there are few doctors in the whole USA that have ever seen a case...I admit I smiled when I saw the discharge diagnosis..This time the medics ordered a chest Xray which revealed free air in the Mediastinum...Differential diagnosis was essentally an esophageal perforation..This condition normally is associated with severe pain in the back which could be a thoracic aortic aneurism..but he had no pain...
He had been seen this time by one of our internists who wrote down R/O Rabies..Well I had to laugh because I knew Rabies was impossibly rare..The only previous case recorded by the US army was in the Civil War...We booked the patient for an esophagostomy...Three of us did it in the OR..Examination of the distal esophagus revealed no perforation..The patient was admitted and a spinal biopsy was performed sent to Naval Hospital at Subic Bay...The biopsy showed Negri bodies..which are diagnostic for Rabies...It is unknown whether Rabies can be transmitted human to human..The patient deteriorated rapidly but could not be transferred to Hawaii, because Hawaii does not allow individuals with Rabies to enter the country...
I bring up this story because everyone who came into contact with this patient needed to go on the fourteen day anti rabies DEV inoculations...
These are sub cutaineous injection given every day for for fourteen days..Very painful injections given in a clocklike pattern around the umbilicus..The injections also cause inflammatory swelling going down to the scrotum..and pain in the inguinal lymph nodes..
It turns out in the three days it took to get the biopsy report back..76 members of the hospital came into contact with the patient and had to go through the innoculations..
So yes one individual who has many around him can potentially infect many others...But it is not as bad as airborne contagion..
":>) JL
Dirbryu,,,
Quote: " It has been reported that a reduction in inflammation is beneficial. Comments?"
Do you read this board? the subject of EPA and the virus has been discussed by me and others..The idea V could help is persuasive..but there are no clinical studies...The most serious aspects of the COV-17 Virus is that it can lead to a Cytokine Storm which produces malignant elevated Systemic Elevation...
Medicine is under the control of the FDA by in large..and the idea would have to be put before the agency which is not known for its rapid responses and most likely the epidemic would be long over before the FDA came to a conclusion...The company has made no comment on using V for urgent treatment of inflammation in those at risk...
":>) JL
ggwpq
Great post...Quote "Regardless of what the government does, people have to take responsibility for their own health."
The idea that this "pandemic" is beyond the control of humans..Is ridiculous...This is a contagion that begs to be controlled..Can be controlled by the simplest of actions...Don't want the virus..don't go out...Don't don't go into area or closures where people congregate...
This virus is not "The Big Bad Wolf"...and its not like polio back in the early fifties..When the medical community did not understand polio was caused by a virus. The COVID-19 virus is one that more or less can only be transmitted by slobbering on someone or having someone slobber on you..Take a bar of Ivory soap with you if you go out..Get some disposable latex gloves..They are like 50 cents a pair...You do not need a mask unless you have the disease and don't want to spread it..Make sure to wipe down your door knobs when you get home..
The virus will weaken over time...a couple of months...The virus will not travel as much in warm climates or warm weather...It's a problem in Northern Italy...Not Southern Italy...The virus is mostly lethal in the elderly or those at risk for CVD events..
I do believe the situation is not being helped by partisan politics or the media putting a political slant on it...I am an agnostic when it comes to politics but I have to confess that I think the democrats have put their own personal agendas and their hatred of the President above the general good of the American people..I have never considered myself a Republican or a Democrat..and confess I have never voted in an election.
Still the President is the President by the will of the people regardless of his personality or whether he is suave our boorish..I have never seen one party go after a sitting President with such venom and we have had some bad ones Carter, Bush (S)..And we need both parties acting in the interest of the American people and not behaving like three year olds..Some of them trying to scare the britches off the people..And the media just diving in..
":>) JL
Jas...
I would like to chime in...Most likely the flash crash was today...That would make it similar to "Black Monday" in 1987...
I think both Black Monday and today were not really "Bear Markets" but rather super corrections...and as such this should blow over sooner than most estimate..A month after Black Monday it was as if it never happened.
I do not believe the contagion and loss of life will be anywhere near what the pessimists are suggesting...My reasoning is the COVID-19 virus is not airborne and airborn dissemination is what makes for global massive death rates because airborne mean inspiration of the vector (virus) and that is to the entire surfaces of the lungs..Which means rapid developing pneumonia which overwhelmed the the victim before any therapy can get them.
This virus is transmitted by spit, saliva, fecal material and probably other body fluids...Which generally means a limited area is infected and must be transported to other parts of the body...Airborne transmission means a single individual can infect a room full of others while surface to surface transmission means only individuals who have very close contact to with a carrier can be infected...
At present we note the creeping up of the numbers and this is not at all like the Great Influenza of 1918...The pandemic of 1918 did not pick off individuals..By the time an outbreak was noticed there would 25% fatalities or more at the occurrence site...Infected in the morning..Dead by twilight time...The 1918 pandemic was spread airborne..No standing around wondering whether you had the virus...No Tom Hanks...or President Trump...waiting for diagnosis..
Even so the 1918 pandemic ended after killing an estimated 100 mil in a world population of one third that of today..
I believe what will do the most to limit the spread of the disease and the deaths is steps each of us can do which cut our risks..That is first and foremost to limit your near term exposures to others and to practice OCD hygene when you leave your home and wash your hands and face when you get home.and wipe the door nobs with disinfectant..This plague does not target hermits...You need another human to get the disease..If you can avoid them then you will live long enough to the time the virus will lose its potency which is what viruses do..
Don't go to movies, restaurants, parties, sports events...or bars..Stay home and watch the tube or video games.Don't get on a airplane unless you have to or God Forbid a Cruise ship...The estimated time till the threat ends, as estimated by Gotlieb, is around 8 weeks...That's only two more months..
And for God sakes do not sell your Amarin stock at these prices..
":>) JL
My focus is on the Player's Championship...
Not in the least bit interested in what the politicians are spewing or what the PPS is on Amarin in this minute...Not going to take the hook and torture myself...Not on margin...Bring it...
":>) JL
Invest...
Quote.."do you believe Amarin management has a clue as to Vascepa's MOA?"
I don't know...What is even more frustrating is I don't know if Amarin's KOLs understand the MOA...I am pretty sure Budoff does not..The company may be following the theory that most of the medical community is ignorant and bringing in issues like the EPA/AA ratio might actually hurt sales..
Maybe the company thinks its better to "dumb it down"..To me its a no brainer...The R-It trial was based on increasing dietary intake of EPA...really nothing more...Facts are lowering trigs by most medications labeled trig lowerers has not proven to be effective in lowering CVD event risk..Although high trigs are a fairly accurate measure of CVD event risk...
"(What most doctors do not understand is elevated Systemic Inflammation (SI) is more effective at raising trigs than increasing diet intake of trigs...And lowering SI will lower trigs if the diet remains the same and lowering SI also lowers CVD event risk...And increasing the EPA/AA ratio will lower SI...)"
....This last paragraph is the message that Amarin needs to get out..Send to every cardiologist PCP and lipidologist...And lastly needs to understand themselves..
":>) JL
G..
I can relate to Dianne's state....
On Dec 6th 1972, literally weeks before the cease fire which ended the full participation of the United States in South Vietnam...The NVA and the Viet Cong carried out a rocket attack on Ton Son Nyatt airforce base...The US Army Hospital Saigon was blocks away from Ton Son Nyatt (always pronounced Nute)...My introduction was the windows of my third story "villa" were blown out at 6 AM...I immediately turned on the radio and got only soothing music..General SMith was in charge of security in the Saigon area and I was present three weeks earlier when he said there was no chance of an attack on the Saigon area..
I jumped out of bed, put on clothes and walked the half block to the hospital emergency staging area and heliport landing. Entering the ER was greeted by rows and rows of patients both military and civilian..The timing
of the rocket attack was perfect..We had three surgeons at the hospital and the other two were out of country...We took 73 casualties within an hour..It was true triage situation..The hospital commander Col Blair was a thoracic surgeon but had done no doctoring for more than 15 years..(a Lifer)...
There were patients totally unconscious without a scratch on them..There were arm and leg injuries..Frag wounds of the chest and abdomen and head injuries..Col Blair accompanied me through the triage and we came to a patient where on of the male nurses was holding pressure over the left clavicular area..Blair asked what was wrong and the nurse took his hand away and the blood spurted six feet in the air...
I ended up being in the operating room for 48 hours with short breaks between cases...The patient with the arterial bleeding had a torn left sub clavian artery...There was only one other such injury reported in the medical history of the Vietnam war. My patient did not survive and perhaps a more experienced thoracic surgeon might have saved him .Only one other patient with a sub clavian artery ever lived long enough to make it to the hospital..The whole experience was exhausting , frustrating, and left me with a sense of spiritual emptiness so well expressed by the Italian lady...
I can say it passes..."The sun also rises and hasteneth to its place"...Ecclesiastes
People need to take responsibility for their own security...This current Virus is not airborn and is spread largely by droplets of saliva..which are aided by hand to mouth..This means you can cut your risk down greatly by staying away from crowds..Avoid close contact with other people and wash your hands...Pretend you are OCD germaphobe...Don't suck your thumb...Don't go on cruise ships..airplanes, theme parks. Or other countries....bunker down wash your hands soap and alcohol..
":>) JL
And the Angel of death passed over...
"Stop sucking your thumb"....
Mother...
chas...
Quote: "Any advice?"
Yes get a Vascepa script and start taking it immediately...Get your ear checked..Most likely you have Otitis Media..Which is a bacterial infection.
":>) JL
KIWI...
Quote: "At last an MD who is willing to tell it like it is."
I am an MD and I always 'tell it like it is"...and I am saying this "pandemic" is a farce...I am not sure what Babr's comments mean..I don't think this Virus is going to create widespread deaths in terms of major fractions of the populations and predict it will pretty much lose traction and disappear...
Time will tell..but 10 deaths in one country and 20 deaths in another country is not very impressive...20 deaths in the United states...that's pretty much Monday morning on route I4 in central Florida...
I am not mincing words here but telling it like it is...and that is my prediction..
":>) JL
BurR...
I like the fact Du (Da Judge) is taking her time announcing her decision.
This signals me she is going to drop the generics down the well..and she is not going to give them the argument that her opinion was a "rush job"...
Imo if the judge announced in the first week and she probably had already made up her mind the Generics would be screaming blue bloody murder. Think about it what other issue could the generics raise.
I would look for the decision sometime next week, or possibly later..twenty one days of thinking it over seems to be about the right time..
"":>) JL
metsfan...
The more I read the opinions and publications by lididologists. The more convinced I become that they are the stupidest collection of "specialists" in all of clinical medicine...
A confederation of numbskulls
":>) JL
jas...
See my earlier post...You probably want to wait until a diagnosis confirms the COVID-19 virus before you begin treating with high doses of EPA...EPA actually lowers SI and that could increase the risk of contracting the disease...Once you are confirmed and you are in the age group at risk then you want to take EPA to prevent the inflammatory "storm" related to the effects of the virus...
Nice to see the scientific community is realising the inflammation is a real problem..
JMO...":>) JL
invest...
Quote: Because I seem to have an extra month supply of Vascepa I’m inclined to take 6 grams a day for the next month or at least as long as the current corona virus scare persists, since I am in several of the high risk categories. any thoughts from those that may have a helpful opinion?
Its complicated but I would stick to 4 gms qd...Too much EPA might actually increase your risk of contracting the virus...You really want high doses after you are diagnosed as it is then that you are at increased risk of very high Systemic Inflammation...JMO
":>) JL
invest...
Quote: "It is now time, if it is not already too late, for the FDA to require each and every drug sold in the US be at least 50% domestically sourced. Our reliance on China and India put us in great jeopardy."
Hear Hear...
":>) JL
circ...
Agree...Hope Amarin will pick up the bit...
":>) JL
circuit...
Thank for the post..The issue of using China is they have the patients..We really don't have enough patients in the USA to run a study...We don't need Vascepa for the young healthy patients that do very well and go home..Its the 2-3% elderly patients that linger on and are more susceptible to problems related to elevated Systemic Inflammation...That Vascepa can help...
":>) JL
Zip...
Amen brother...
I don't run the company and they don't listen to me...The virus is not the problem..Its the high Systemic Inflammation..and Vascepa is the best drug in the world at combating elevated SI..Most of the financial cost of the epidemic is going to be related to the intensive care aspects...The pneumonia and the CVD events...Vascepa could save the country not only lives...but a lot of dollars..
":>) JL
jf...
The separations in the R-I trial are not because the drug works slowly..Its that the events occur slowly and without more events we do not get further separation..
In the case of the virus the scenario plays out in a much shorter time period... In a couple of weeks..You either get better or you "box".
The important point is even though the virus is very good at infecting new patients it is not so good at killing them..So most of them go back into the work force with what is for most purposes a cold...And yes I am in that category of those the Virus can kill...So I must be careful and stay away from people and wash my hands..If I get this flu...I will take Vascepa as I always do...I am not at all worried...I do worry about cancer, but not the COVID-17 Virus.
Bhatts point which he made earlier is medical conferences are not necessarily very cost effective or the ideal way to further medical education...I'm sure they are probably a pain in ass to him and he would rather stay home and have film crew come in and record his presentation for dissemination to his medical colleagues..
":>) JL
Michael...
Quote: "Doesn't it take some time for V to show results ? TIA"
Good comment...In an acute situation...very likely it would just depend on what the EPA/AA ratios were...And they could be reached in a few days..The point here is Vascepa seems to be the logical choice as there are so few alternatives..The possibility it would not work or take to long to work is a reality..But since the side effects are so mild...If I contracted the disease I would be screaming at them to put me on Vascepa..And I am in the group who is at risk for dying from the virus...
":>) JL
Chemist2,,,
Perhaps I should have not used the word "scam." What I do mean is the threat is wildly exaggerated..You are entitled to your opinion....I don't agree with you and you offer no real argument..Just a speculation.
":>) JL