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The difference is Gingko Biloba is an OTC herb supplement and is relatively cheap. 2-73 will be a drug that will only be available by prescription and will be much more expensive. Not to mention that unless some agency approves 2-73 it won't be available for anyone.
Apples and oranges comparison.
My bad. I should know better than to argue with you.
I have a request/suggestion. When the list of posts is shown on a stock board all the various emojis are shown along with a total emoji count.
I think it would be helpful of the emojis were shown in descending order so you would have a sense of the sentiment by looking at the emoji order.
Now one has to open the post to see the counts and determine what the emoji are indicating about the sentiment related to that post.
Does that mean you have finally sold your 11 million shares?
You can't handle the truth.
The truth is you don't know and neither do I.
We can speculate all day long.
I'm not defending anyone. I'm telling you that you are out of line calling people liars all the time.
Have you talked to Jin? Do you know why he took the job?
There are many reasons he may have had for joining Anavex. Unless you have had him tell you why he joined Anavex your guess is no better than anyone else's.
Aren't you a former CEO? I would think you would have a good idea of what is involved in running a company with a multi million Dollar budget that is running multiple projects simultaneously.
That couldn't be a disingenuous comment could it?
I guessed you missed the word "maybe" in his post. That takes out of the declarative statement category i.e. outright lie, into the insinuation category which is not a lie by any definition.
insinuation
noun
An unpleasant hint or suggestion of something bad.
His post may have been tacky or perhaps just stating a possible different explanation for a set of circumstances.
Either way calling it a lie is huge overreach on your part.
Georgejjl when are you going to quit accusing anyone that posts something you don't agree with of posting lies?
Many of us have made money on Anavex. There are the day traders, the swing traders, options traders, and those of us that have a core position, which we hold, and a smaller amount of trading shares.
There is another opportunity to make a few bucks coming up. We are told that every time there is a conference call the share price drops. So sell some shares now and buy them back after the CC drop.
If you aren't making money on Anavex you may want to reexamine your approach.
Wishful thinking.
Lawsuit is coming ...
There is no "pivot". Pivot means turning away from something towards something else.
There is no indication that Anavex is turning away from 2-73. Currently Anavex is waiting for guidance from the FDA about Rett. Can Anavex file based on what the trial results are, does it need to run an new trial, if so how big and how long?
AD is in progress with the EMA. My guess is that Anavex will decide what to do in the US and AU based on the feed back it gets from the FDA on Rett.
Starting work on 3-71 has been in the developmental pipeline for quite a while. The P1 has been done and was successful so now on to P2 trials. All part of the normal pipeline development process.
Drug development is never easy. Ask NWBO.
Very interesting new findings on neuron health in AD with possible restoration of function.
https://medicalxpress.com/news/2024-02-scientists-potential-synapses-alzheimer-disease.html#google_vignette
So what's your point?
People attack the CEO and people defend the CEO, what's the problem?
And it is your duty to protect the great unwashed from him? Sorry, but that is pretty sad. Following him for years you say. Wow. My choice of the word obsession was well chosen it seems.
Like I said., board noise, like many others.
That is a ridiculous answer. You are staying with Anavex because you feel it is your duty to counter balance stuff on a minor message board. Really?
I assume you have no money at stake in this endeavor. If that is the not case your reasoning makes absolutely zero sense.
I am fascinated by your obsession with George. Most of his posts are just so much board noise like many other posts and posters.
The ninny wars continue.
Doxing (sometimes written as Doxxing) is the act of revealing identifying information about someone online, such as their real name, home address, workplace, phone, financial, and other personal information. That information is then circulated to the public — without the victim's permission.
I hub rules prohibit Doxing. Notice that doxing is real names and real information. An I hub alias is already public information and is anonymous.
I hub will not reveal the real identity of an alias without a court order.
Another reason that sleep apnea causes problems is you don't get into deep sleep which is when the brain moves the metabolic wastes out of the brain.
A new study conducted at the University of Rochester Medical Center has found that brain activity during deep, non-REM sleep is ideal for the brain’s glymphatic system to “clean” itself of toxins. Some of these include the toxic proteins beta amyloid and tau, the buildup of which has been linked to Alzheimer’s and dementia. Beta amyloid and tau are thought to harm and inhibit communication between neurons.
“Sleep is critical to the function of the brain’s waste removal system and this study shows that the deeper the sleep the better,” said Maiken Nedergaard, co-director of the] Center for Translational Neuromedicine at the University of Rochester Medical Center and lead author of the study. “These findings also add to the increasingly clear evidence that quality of sleep or sleep deprivation can predict the onset of Alzheimer’s and dementia.”
This study emphasizes the link between poor sleep and Alzheimer’s and underscores the importance of maintaining brain health as a part of a complete approach to fighting Alzheimer’s.
Normal day for our biotech.
Was not specific to you. You just got lucky and that was the post I was reading when I decided to post.
The post was meant for the board in general.
This board reminds of elementary kids yelling at each other "you're a ninny" and the other kids yelling "no, you're a ninny". " no, you're the ninny 'cause I called you one first". Etc.
Is it possible we could get back to discussing the company and its products and leave the assessment of posters motivations up to each reader?
Interesting findings about AD. 2-73 may have positive effects on mitochondrial function.
https://medicalxpress.com/news/2024-01-energizing-mitochondria-alzheimer-disease.html
Not really. This has been trading in a range of late. So I don't see this as telegraphing anything.
The company has not announced the letter of intent that I am aware of. I would not be surprised if Missling never announces the letter of intent.
You can post whatever opinion you want. Expecting everyone to agree with it is unrealistic. This is an anonymous message board which lends itself to people behaving more poorly than they would in a face to face situation.
If a little name calling is a bit too much for you then ...
Actually they did. The EMA approved 2-73 for the centralized approval path which is a necessary first step in the overall approval process.
If that was not approved it would be game over for AD in the EU.
How about a little subtlety.
The Rett trial was not the clear success that was hoped. Everyone can agree with that I think.
It also wasn't stopped for futility which is a clear failure. Although that didn't stop Adulhelm from going forward after two trials were stopped for futility and it was still approved. So there's that.
There was some evidence of efficacy in the trial. That level of efficacy did not rise above the placebo effect sufficiently to meet the P<0.05 requirement.
There is also the anecdotal examples of reduced seizures in Rett girls. The trial did have a seizure log as a measure. Whether the seizure logs support that as a real result could have an impact on what the FDA thinks about the overall trial results.
So, whether the Rett trial results in approval or not is still up in the air. That decision will be made by the FDA. If the FDA says go ahead and submit an NDA the trial was was a success. If the FDA says run another trial to clarify the situation the trial was not a failure nor a success. If the FDA says don't bother with an NDA the trial was a failure.
What can be said is that endpoints were not met with P<0.05.
There are other factors that are involved that are not included in your analysis. There is unmet need which may mitigate the only one P3 trial issue. There is also the very low SOC which may have the AD results viewed more favorably than your analysis considers. There is the relative safety of 2-73 to be considered. One can argue that a safe but ineffective drug still doesn't get approved. However given that the approved MABS have marginal efficacy and significant safety issues, it is hard to predict where 2-73 will come out in that evaluation by the EMA.
Then there is the financial burden issues of AD. The EU seems to consider that with the rejection on the MABS for a cost benefit ratio consideration. 2-73 looks to be considerably cheaper that treatment with the MABS.
The points you make are legit. I'm suggesting there may be other considerations that are not included in your analysis.
We shall see what the EMA decides in due course.
Pivot is not word used by Anavex. It is a description used by posters on the MB.
The initiation of the 3-71 trial is a normal development of the drug pipeline. Nothing more and nothing less.
The company can do more than one thing at a time and develop more than one drug at a time.
You know the only thing that has changed is the Rett trial. That was expected to be a clear success and it wasn't. Whether it was a clear fail will be decided by the FDA. We don't have the answer to that yet.
AD is still moving forward and a new trial for 3-71 has be initiated.
It may not be WGT and it still looks pretty good to me.
It is not a 7 month wait after filing. It is a 7 month wait after notification of an intent to file. A significant difference. The actual filling occurs after the 7 month notification of intent to file. There are some circumstances that can shorten that time but it seems that most cases require the 7 month wait to actually file the MAA.
Thank you for bringing that data to the board.
Investor, Please go snipe at someone else. I have no desire to play your silly games.
I think you read too much into the 3-71 trial. That is the normal progression of developing a pipeline.
Doc, so far the regulatory agencies have yet to express an opinion on 2-73 in any trial. So we don't know how convinced or not they are.
We have your opinion, informed as it is. The agencies will see a lot more data ,in much greater detail, than any of us has seen.
We shall see what they have to say.
My reply was to someone else who made the claim that the Blackrock Anavex shares were only index funds.
Sometime ago I posted a Blackrock discretionary fund that owned Anavex. I'm sure you can find more if you are interested.
That argument is just wrong.
Number of BlackRock funds worldwide in July 31, investment style and fund type
Published by Statista Research Department, Sep 1, 2023
As of July 31, 2023, the allocation between actively managed and index funds operated by BlackRock was fairly even. Of the 1,098 funds operated by the world's largest asset manager, 590 were actively managed while 501 were index funds. Not surprisingly, the majority of mutual funds were actively managed, while only a handful of BlackRock's exchange traded funds were actively managed.
Seems to me it has worked out pretty well.
Money in the bank. Approval process started for AD in the EU. Rett is still alive, if delayed. Schizophrenia trial initiated.
Not nearly as fast as people want.