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I'm glad your eyes are on Vietnam Lebbe1.
"This Decision takes effect from the date of its signing." ???
Has this happened?
I second that.
I agree with you about the upcoming newsletter. Also it feels good to know the company is more in control of its own destiny with the addition of the new equipment. This machinery should be a big boost for accelerating sample deliveries of even more advanced technical textiles Beyond dragon silk and the shoot packs. Of course I wish that delivery had been right on schedule but in the big picture we are ahead of the game. At this point I feel better about my investment than ever really. Rock On KBLB! It's a journey but we are getting there.
Excellent buy Z
that's a lot of shares. You are going to be a very happy man.
I think many who are being negative are only making a lame effort to get the PPS down to buy more with their transparent and verbiage. I suspect they are actually quite envious of your stash. Just my humble opinion.
I have always admired this companies technology. Glad to see things going well for you guys. We are next. :)
"whist we find fault and thievery" That was my favorite part of that one.
I'll have what he's having.
Yes Cleantrade. I feel the same way. Your average is fantastic. . Great buys you had ole boy!
True. I was hoping there would be a comments section at the bottom of the article but I did not see one.
"The future is made in the lab"
Words to live by.
https://defence.pk/pdf/threads/us-company-builds-genetical-spider-silk-factory-in-vietnam.485998/
Same article but interesting source.
Sounds more like redman, man.
"Get um while they are cheap! "
This is excellent! It's nice to see the path to commercialization coming more into focus. I don't want to start counting my transgenic silkworms before they hatch by the millions in Vietnam but I must say that the large scale production we have been anticipating for so long seems very close and very real now. Show me the final approval at the federal level please ASAP Kim. I need to exhale. Ha ha. Congratulations to all of us who have seen the potential for so long and to this inspiring visionary company.
I do agree with you on that one.
http://www.refinedguy.com/2017/03/20/bolt-threads-spider-silk-neckties-video/
It's a bird it's a plane no it's supergoo ties. Humble is an overstatement.
Maybe they are afraid of actual existing super fibers that they know their goo can never compete with.
That sounds like an "alternative fact" to me. ;)
Thank you, very informative. They mentioned that yeast is superior to bacteria for this. Did they happen to make a comparison to silkworms?
Yes I think the spinning abilities will eventually improve to some degree for the goomisters but that's not to say that strength and elasticity will substantially. Do you recall what was said on this board sometime ago regarding the shorter lengths of proteins produced by bacteria and the limits of their capabilities relative to longer chain Silkworms? I'm nobodies scientist and would like to get opinion from those who are.
I did not mention anything about creating a website.
I see your point about the lifespan of whatever platform animal may be used. However I still believe silkworms are the superior way to go forward even though one may not be able to make and see genetic changes as rapidly as with bacteria, the changes you can make in silkworms are being made to an animal that has already got the silk making thing down and can more easily incorporate dragline silk characteristics to the final product rather than a big teaming vat of bacteria that does not already have silk in it's DNA to begin with. Take the best existing vehicle mother nature has evolved and improve on that seems like the way to go.
Eska, I would never encourage anyone to be "hostile" only politely informative. Also I don't think Bolt was the first to market transgenic spider silk because of "shorter microbial life spans" rather KBLB's desire to have a superior product in quantity when they ultimately go to market. IMO Additionally, I believe Kim is already using "protein based fibers" with the silkworms. Maybe jazz can clarify that for us.
I agree.
It seems as though Bolt is getting a tremendous amount of press coverage in a wide variety of news and other informational outlets. It is no surprise that this is the case as people have long awaited the first transgenic spider silk product. (such as it is)
Given the low performance technical quality of this $314 necktie, to me which amounts to little more than a publicity stunt, it is apparent to the very few of us who are somewhat well informed relative to the general public that KBLB has a vastly superior product and platform to monopolize the spider silk technical textiles Industry and create a vast footprint in the world of mundane silk products. This publicity stunt by Bolt is apparently wildly successful. The net is flooded with articles on this recent development. This is a fantastic opportunity for us as motivated active shareholders to make the world aware of what we have and potentially bring many new investor's dollars into the company and justly increase the value and pps. I have a challenge for the people who believe in this company. There are several of you who are obviously very well informed and quite eloquent in written communication. You could use your talents to enlighten the world as to the potential of Kraig Biocraft. The rest of us can play a huge part in this as well. How do we do it? Let's incorporate the knowledge of what we have in KBLB in every article and publication that we see on the Internet that has a comments or response option at the end of the article. Given the amount of coverage this could be a great tool to help our cause. Let's respond with our opinions and supporting links and quoted copy whenever the opportunity presents itself at the comments section of these published news articles and other stories. It cannot hurt and could possibly be extremely advantageous to us. Some here will say that promotion is not the job of the shareholder. It is the job of the company. They are correct. However when there is something that so many of us believe can change the world in a positive way and help our own prosperity why not look at it as our fiduciary responsibility to ourselves? Go forward into the world and spread the good word my friends.
Sent from my iPad
Yes gimme. In a very few words it does speaks volumes. All of the goo companies can make no greater claim than Bolt to the most profitable technical textiles future. KBLB Is indeed the leader and without peers. IMO
My humble recommendation to all is buy on the dips and hold them long and strong for a massive successful return on investments in this company. IMHO. Not trying to cheerlead, just looking at the facts. Among everyone else attempting to complete we are head and shoulders above all of them when it comes to spider silk quality and a platform for relatively inexpensive production. When I consider that we already have fibers that are even better than Dragon Silk it gives me comfort and optimism.
https://www.technologyreview.com/s/603817/synthetic-spider-silk-for-sale-in-a-314-necktie/
Bolt’s Breslauer says his assumptions about what synthetic spider silk might be useful for have changed over time. “The allure of spider silk made me assume we’re going to make some technical material,” like fibers for bulletproof vests, he says. The silk in Bolt’s tie, he says, is not a super fiber, which is inherently more difficult to manufacture.
Ha! Good one.
Correct me if I am wrong but I believe that many people in agriculture use the term "cloning" rather than what they are actually doing which is simple"rooting" of the plant. No complicated true cloning going on just continuing the exact genetic material through rooting a small branch in water and easily available growth stimulating agricultural chemicals. Once the first "trees" are growing the company can get almost limitless cuttings to produce more of the same exact plant for expanded production.
Traditionally, the concept of a material created from spider silk that’s robust sufficient to face up to excessive forces corresponding to being hit by bullets, however delicate and cozy sufficient to be worn as regular, on a regular basis garments has been a dream for hundreds of years, however few have been capable of produce it till very lately.
Within the early 1700’s, the primary recorded use of spider silk was by Francois-Xavier Bon de Saint Hilaire, a Frenchman who was efficiently capable of harvest sufficient silk instantly from spiders to provide gloves, socks, and even a full go well with for his king, Louis XIV. It was mentioned that he would exit and collect lots of of spiders at a time and retailer them in crates solely to return and discover just a few left as a result of the truth that spiders tend to eat one another when positioned in shut proximity.
Somewhat over 100 years later, a Spaniard working in Italy named Raimondo de Termeyer was capable of produce a pair of stockings and a scarf for Emperor Napoleon and his then spouse Empress Josephine. He was in a position to do that through the use of a machine that he invented that might immobilize the spider and take away the silk with out harming the spider.
Within the late 1800’s, a French Jesuit missionary named Jacob Paul Camboué who lived in Madagascar started experimenting with extracting silk from spiders. He later teamed up with one other Frenchman who glided by Mr. Nogué and, impressed by Termeyer’s design, created a hand powered machine able to extracting silk from as much as 24 spiders concurrently and mixing it into one steady strand. Utilizing this machine, the workforce was capable of create a set of mattress hangings which was on show on the 1900 Exposition Universelle in Paris.
Extra lately in 2004, utilizing the design documented by Camboué and Nogué, Simon Friends and Nicholas Godley tried to recreate the machine and create their very own spider silk cloth. Each morning they collected new spiders, “milked” them for his or her silk, and returned them to the wild once they had been achieved with them. The whole course of was extraordinarily sluggish and the quantity of silk that may very well be acquired from every spider was very minimal as a result of it takes round 23,000 spiders to provide just one gram of silk. So, over the course of 5 years, utilizing over a million spiders, and spending half 1,000,000 , they’d lastly produced sufficient silk to weave a single golden cape adorned with intricately embroidered and appliquéd motifs that depict the spiders that had been used to generate the fabric. This cape is claimed to be extremely robust, but as delicate as cashmere.
Milking spiders for his or her silk may also be used for functions apart from textiles. An previous wound treatment that was used way back to the Roman Empire included gathering spider silk and making use of on to a wound to assist the therapeutic course of. Borrowing from this, the Division of Plastic, Hand, and Reconstructive Surgical procedure within the Medical College Hannover in Germany has developed a solution to make the most of a woven mesh of the dragline silk extracted instantly from Nephila spp spiders to create an “synthetic pores and skin” which may be utilized to the pores and skin to restore it with none immune system response. They did this by inserting regular pores and skin cells onto a spider silk mesh and, in the suitable situations, had been capable of create the outer and internal layer of skins in solely per week’s time. This may very well be used as a pure various to cosmetic surgery to regrow pores and skin on burn and trauma sufferers.
Sadly, as a result of massive variety of spiders that’s required to provide only a small quantity of silk and spiders’ cannibalistic nature, it’s impractical to reap silk instantly from them. Realizing this, there have been and are at present many corporations and organizations making an attempt to get round this by racing to develop and commercialize fibers which have properties much like that of pure spider silk.
In 1993, an organization referred to as Nexia Biotechnologies Inc. was based in Montreal, Canada by Dr. Jeffrey Turner and Paul Ballard. Initially working and failing to provide lactose-free milk, it discovered new route when Dr. Jeff Turner steered that they work to include spider DNA into the milk to provide spider silk proteins. By licensing analysis achieved by one of many world’s prime researchers on spider silk, Dr. Randy Lewis, they remoted and cloned the proteins for spider silk and had been lastly capable of produce 10 grams of spider silk proteins in goat milk in 2002. At full capability, they had been producing small portions of the proteins with every batch of milk harvested and spinning a few of them right into a fiber that they named “Biosteel&commerce;”. Sadly, with the extraordinarily restricted quantity of proteins that may very well be created along with the excessive value to provide these proteins, they discovered that the enterprise was unsustainable. They ended up promoting most of their property in 2005 and eventually went bankrupt in 2009.
Dr. Randy Lewis was not giving up and was decided to take this concept additional. He took the concept of the “spider goats” and ran with it in parallel with Nexia Biotechnologies, creating his personal breeds whereas figuring out of the College of Wyoming. He was additionally in talks with Dr. Don Jarvis, a famous molecular biology professor that specialised in silkworms on the College of Wyoming, to by some means incorporate the spider DNA into the silkworms in the same method because the goats.
In the meantime, Kim Thompson, a enterprise lawyer with a powerful curiosity within the course of of creating synthetic spider silk, had contacted the College of Notre Dame’s Dr. Malcolm Fraser. Dr. Fraser was one of many preliminary scientists that had labored on producing the primary transgenic silkworms in addition to one of many researchers who was capable of develop a technique to switch the DNA in a particular a part of an insect with one other distinctive sequence. He referred to as this technique “piggyBac”. Thompson was extremely taken with utilizing this technique to switch the DNA within the silkworm’s spinnerets with spider DNA. Collectively, Thompson and Fraser contacted Lewis and Jarvis and determined to work collectively to create this synthetic spider silk.
In 2006, Thompson based Kraig Biocraft Laboratories Inc. and commenced working to create transgenic silkworms which were injected with spider DNA. In 2010, they lastly achieved their aim and created a silkworm able to spinning a a lot stronger silk, which the corporate dubbed “Monster Silk®”. They revealed their strategies and findings in a PNAS paper and begun ramping up the manufacturing of silkworms to industrial portions. Since then they’ve additionally licensed one other technique for extra exact gene insertion referred to as “Zinc finger” from Sigma-Aldrich. Utilizing this technique, they had been capable of produce a good stronger fiber which they dubbed “Massive Purple”. Just lately, they’ve been working with Warwick Mills, a technical textile firm primarily based in New Hampshire, to check and develop their fibers into sensible purposes. They’re additionally in talks with the Vietnamese authorities to construct a industrial manufacturing facility pending Vietnamese laws. They’ve acknowledged that they hope to be at industrial manufacturing ranges of Monster Silk® as early as this yr.
Dr. Randy Lewis has since moved on together with his work, trying to additional develop the manufacturing of synthetic spider silk. Bringing his “spider goats” with him, he transferred to Utah State College and began diversifying his work, injecting spider DNA into many organisms corresponding to alfalfa vegetation, E. coli micro organism, and silkworms utilizing much more lately developed strategies for changing DNA such because the CRISPR/Cas9 system. In 2012, he based his personal firm, Araknitek Inc., and is decided to deliver his personal model of synthetic spider silks to the market.
Different corporations have seen the chance that these fibers can present and have began improvement utilizing their very own strategies.
In England, Oxford College’s silk analysis group lead by Professor Fritz Vollrath with Dr. David Knight based an organization named Spindox Ltd. Quite than inject spider DNA into silkworms, they’d developed a technique to spin silkworm silk proteins right into a stronger silk fiber that resembled the properties of pure spider silk by cleansing and modifying the fibers. They named this fiber “Spidrex®”, modified their title to Oxford Biomaterials Ltd., and are at present engaged on producing vascular grafts which can be extra dependable than these available on the market at the moment. They’ve additionally produced three spinoff corporations utilizing and creating Spidrex® fibers: Suturox Ltd., Neurotex Ltd., and Orthox Ltd.
Suturox was based in 2007 and hoped to develop naturally biodegradable sutures made type Spidrex®, however had been unable to take action and had been dissolved in 2013. Neurotex, based in 2006, hopes to commercialize a Spidrex® nerve conduit and is at present working to prefect it. Orthox, based in 2008, makes use of Spidrex® fibers to develop a cartilage substitute that they dubbed “FibroFix&commerce;”.
A German startup firm referred to as Spin’tec Engineering GmbH. Based by Dr. Michael Rheinnecker in 2004, bought the spinning know-how from Oxford Biomaterials Inc. and has since improved upon it. They’re at present working with their very own breeds of silkworms and have been embedding organic brokers into the silks from the silkworms whereas nonetheless spinning them in such a approach that may produce a thread with properties approaching a spider’s thread. They hope to make use of these threads to help with bone therapeutic, wound therapeutic, and creating synthetic tissues and organs in addition to different medical and pharmaceutical makes use of. They’re at present working with the KLS Martin Group to develop an modern maxillofacial product.
One other German firm has been creating a man-made spider silk utilizing a unique technique. AMSilk GmbH is utilizing E. coli micro organism which were genetically modified with spider DNA to provide spider silk proteins. They’ve already efficiently commercialized lotions and powders for beauty use that they named “TruSilk©” and are at present engaged on making a coating for breast and different silicone implants which they name “Bioshield-S1©” to cut back the potential for the physique rejecting the implant. In addition they are near commercializing an over-the-counter wound care patch that they name “SanaSilk®” that may maintain the wound clear and hydrated. They’ve even been profitable spinning fibers from the proteins. They named these fibers “Biosteel®” after Nexia Biotechnologies deserted the trademark. They’re at present working to optimize these fibers and convey them to market.
AMSilk shouldn’t be the one firm utilizing modified micro organism to provide its silk. Spiber Applied sciences AB was based in 2008 in Sweden primarily based on the analysis from the veterinary school on the Swedish College of Agricultural Sciences. The founding researchers found a technique to provide synthetic spider silk in physiological situations and have since developed a recombinant spider silk protein that they name “Spiber&commerce;”. These proteins are very versatile as they are often spun right into a fiber, made into a skinny movie, frothed into foam, or minimize right into a mesh for customized makes use of. Spiber&commerce; may also be bioactivated with extra capabilities to higher go well with remaining purposes. The corporate is at present engaged on perfecting using their Spiber&commerce; proteins for wound therapeutic, implants, and different medical purposes.
One other firm with virtually the identical title, Spiber Inc., was based in Japan in 2007. The selection for his or her title was coincidentally the identical because the Swedish firm they usually additionally use modified micro organism to make their silk proteins, however they aren’t working collectively. Since their formation, they’ve began working with Kojima Industries Company and the Korea Superior Institute of Science and Expertise (KAIST) and have been capable of construct a small pilot facility able to producing 100Kg of silk protein a month. They’ve spun a few of this protein right into a fiber that they’ve referred to as “QMONOS®” (pronounced “kumo no su” which means “spider internet” in Japanese) and have woven a gown from it. They’ve lately began establishing a good bigger facility able to producing 20 metric tons of silk protein a yr at full capability and created a derivative firm referred to as Xpiber, Inc. They plan on promoting the proteins and fibers for sensible purposes by the yr 2017.
An American firm based in 2007 in North Carolina by Dr. David Brigham named EntoGenetics Inc. can also be trying to create their very own transgenic silkworms. It’s Brigham’s aim to provide 100% spider silk from a silkworm and produce the whole lot to make the silk within the USA. Initially figuring out of his residence and lately rising mulberry on marginal land at a repurposed water remedy plant, he has created a really robust silk and has a contract with the Military to provide bulletproof vests. He’s at present within the means of increasing operations.
Even one other American firm based in 2009 in California by UCSF graduate Dr. Dan Widmaier and his associate, UC Berkeley graduate Dr. David Breslauer, goes by the title of Bolt Threads Inc. They’ve lately modified their title from Refactored Supplies Inc. and are additionally trying to provide a man-made spider silk. Their preliminary experiments had been working with utilizing transgenic salmonella to generate the silk proteins and have since moved on to different strategies. Since their founding, they’ve been granted over $1 million by the Nationwide Science Basis and a contract with the Division of Protection to provide bulletproof vests. They hope to start out promoting their silk commercially by 2016.
The Okamoto Company, a Japanese luxurious sock firm, introduced in 2007 that they’re engaged on a brand new sock created from spider silk as generated from genetically altered silkworms. They’re at present working with Shinshu College’s School of Textile Science and Expertise to commercialize these socks and have already produced a prototype pair of socks. They’re at present engaged on making a silkworm analysis and breeding heart that must be up and working by spring this yr.
Like Nexia Biotechnologies, another, higher established corporations which have additionally jumped on the factitious spider silk bandwagon have not achieved so properly In 2001, DuPont, the producer of Kevlar, had experimented with injecting spider DNA into vegetation, silkworms, and E. coli micro organism to provide fibers with the energy of spider silk, however gave up on the venture after just a few years as a result of they may not obtain the mechanical properties that they wished in a constant method.
Synthetic spider silk is of nice curiosity and is at present being researched at many universities. Virtually each firm listed was spun out of a college and there are lots of extra within the means of creating spider silk that will type an organization and try to commercialize sooner or later. For instance, the Nationwide Institute of Agrobiological Sciences (NIAS) in Japan has produced their very own transgenic silkworm and has lately used its silk to knit a sweater and scarf and documented the whole lot in a PLOS One article. They’ve even lately visited the Indian Andhra Pradesh State Sericulture Analysis and Growth Institute (APSSRDI) and checked out their transgenic silkworm packages. They’re now trying into increasing manufacturing there.
The Wyss Institute for Biologically Impressed Engineering has created genetically modified shrimp injected with spider DNA to reap their cartilage that they named “Shrilk” to be able to create an environmentally pleasant, biodegradable plastic.
The Southwest College in Chongqing, China, Tufts College in Medford, MA, USA, the College of the Pacific in Stockton, CA, USA, and sure many others have all been working individually on creating their very own model of spider silk.
Modifying organisms with spider DNA has turn out to be so widespread workforce of scholars from the College of Bordeaux in France even determined to change E. coli micro organism with spider DNA themselves for entry into the 2014 Worldwide Genetically Engineered Machine (iGEM) competitors wherein they received a bronze medal. They’ve named this micro organism “Elasicoli” as a result of its elastic nature, and offered it as a viable inexperienced various producing to plastics, various to medical sutures and substitute tendons, and technique to create stronger textiles.
Even with so many corporations and organizations concurrently racing to provide these merchandise, there’ll nonetheless be loads of room for different rivals to flourish available in the market as these fibers begin to overtake and substitute the present leaders within the business. It’s only a matter of time earlier than we are going to begin seeing these spider silk merchandise stocked in shops and hospitals worldwide.
Sources:
“François Xavier Bon De Saint Hilaire.” Wikipedia. Wikimedia Basis, 26 Oct. 2014. Net. 5 Nov. 2014.
Ward, Rebecca. “Golden Spider Silk.” Victoria and Albert Museum. 25 Jan. 2012. Net. 5 Nov. 2014.
Joyce, Christopher. “Spider Wranglers Weave One-Of-A-Variety Tapestry.” NPR. 27 Sept. 2009. Net. 5 Nov. 2014.
Wendt H, Hillmer A, Reimers Ok, Kuhbier JW, Schäfer-Nolte F, et al. (2011) Synthetic Pores and skin – Culturing of Totally different Pores and skin Cell Traces for Producing an Synthetic Pores and skin Substitute on Cross-Weaved Spider Silk Fibres. PLoS ONE 6(7): e21833. doi:10.1371/journal.pone.0021833
“Nexia Biotechnologies.” McGill Unversity. 30 Oct. 2002. Net. 5 Nov. 2014.
Pelzer, Jeremy. “College of Wyoming Professor Helps Create ‘monster’ Silk.” Casper Star-Tribune On-line. 1 Feb. 2012. Net. 5 Nov. 2014.
Noel, Joseph. “Kraig Biocraft Laboratories, Inc.” Rising Development Analysis, 26 Jan. 2009. Net. 5 Nov. 2014.
F. Teule, Y.-G. Miao, B.-H. Sohn, Y.-S. Kim, J. J. Hull, M. J. Fraser, R. V. Lewis, D. L. Jarvis. Silkworms reworked with chimeric silkworm/spider silk genes spin composite silk fibers with improved mechanical properties. Proceedings of the Nationwide Academy of Sciences, 2012; DOI: 10.1073/pnas.1109420109
“A Technique of Spinning Spider-like Silk, the ‘Holy Grail’ of Bio Supplies.” Oxford College. Inside: Expertise, Problem eight, The Expertise Partnership Plc., 20 July 2012. Net. 5 Nov. 2014.
Kuwana Y, Sezutsu H, Nakajima Ok-I, Tamada Y, Kojima Ok (2014) Excessive-Toughness Silk Produced by a Transgenic Silkworm Expressing Spider (Araneus ventricosus) Dragline Silk Protein. PLoS ONE 9(eight): e105325. doi:10.1371/journal.pone.zero105325
“Crew:Bordeaux.” Net. 5 Nov. 2014. < http://2014.igem.org/Crew:Bordeaux >
Fujisaki, Masahiko. “Challenge underneath Approach in Kyoto to Commercialize Spider-silkworm Thread – AJW by The Asahi Shimbun.” AJW by The Asahi Shimbun
I hear you I B.
I would love to see these girls in our DS pajamas for VS.
I would like to nominate PFS to be the new KBLB advertising agent.
Asked and answered.
Monster Silk may end up having several applications combining fabrics with it other than silk.
Personally I want to corner the world trampoline market using Monster Silk. Lots of applications out there.