Life long Maverick: Seen it ALLl in 40 yrs of PROF. exposure as invest analyst/port mgr on the FRONT lines vs iHub Msg Bds.
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USA REALITY vs nonstop online obfuscations never hitting the mark:
Editor's picks
MARCH 12, 2020 / 03:42 PM / UPDATED 2 MINUTES AGO
Material shortages for Test Kits & BACKORDERED; AND on ALLOCATION & PROCESS COMPLICATIONS to COMPOUND/ PROLONG:
Coronavirus testing in U.S. threatened by shortage of critical lab materials
The slow pace of coronavirus testing has created a major gap in the U.S. public health response.
Read in POLITICO: https://apple.news/AIzm1W1NZSju9aWBDmaoP5w
Exclusive: U.S. coronavirus testing threatened by shortage of critical lab materials
The slow pace of coronavirus testing has created a major gap in the U.S. public health response.
A looming shortage in lab materials is threatening to delay coronavirus test results and cause officials to undercount the number of Americans with the virus.
The slow pace of coronavirus testing has created a major gap in the U.S. public health response. The latest problem involves an inability to prepare samples for testing, creating uncertainties in how long it will take to get results.
CDC Director Robert Redfield told POLITICO on Tuesday that he is not confident that U.S. labs have an adequate stock of the supplies used to extract genetic material from any virus in a patient’s sample — a critical step in coronavirus testing.
“The availability of those reagents is obviously being looked at,” he said, referring to the chemicals used for preparing samples. “I’m confident of the actual test that we have, but as people begin to operationalize the test, they realize there’s other things they need to do the test.”
The coronavirus task force convened by the White House is also aware of the shortages, and one official said members are working on it.
The growing scarcity of these “RNA extraction” kits is the latest trouble for U.S. labs, which have struggled to implement widespread coronavirus testing in the seven weeks since the country diagnosed its first case. Epidemiologists and public health officials say that the delayed rollout, caused in part by a botched CDC test, has masked the scope of the U.S. outbreak and hobbled efforts to limit it.
If enough processing kits aren’t available, the risk that testing will be disrupted is “huge,” said Michael Mina, associate medical director of molecular diagnostics at Brigham and Women's Hospital in Boston.
“RNA extraction is the first step in being able to perform” a coronavirus test, he said. “If we cannot perform this step, the [coronavirus] test cannot be performed.”
Qiagen, a major supplier of the kits, confirmed that its product is backordered due to “the extraordinary pace” at which the world has increased coronavirus testing over the last few weeks.
Public health labs across the U.S. have tested more than 5,000 people, according to the Trump administration. HHS Secretary Alex Azar told lawmakers on Tuesday that U.S. labs’ capacity could grow to 10,000-20,000 people per day by the end of the week.
“Increased demand for testing has the potential to exhaust supplies needed to perform the test itself,” said Robin Patel, president of the American Society for Microbiology. That would limit the testing capacity of public health, hospital and commercial labs alike, she added.
Complicating the situation, most labs have been running at least two tests per patient — although that could soon change. The CDC issued interim guidelines on Monday that minimize the number of tests required for a diagnosis. The agency says labs can combine a patient’s nose and throat samples into one test, a move experts say will cut in half the amount of supplies used to test each person.
But Redfield said he doesn’t know how the agency would deal with any scarcity of RNA extraction kits and reagents that arise. “I don’t know the answer to that question,” he said when asked how the CDC would handle such a situation — adding that he is hopeful “there will be mechanisms between multiple manufacturers to correct” it.
Mandy Cohen, North Carolina’s secretary of health, said that a shortage of extraction kits and other chemicals had hampered testing in her state. “Folks were saying, ‘We are sending you the [test] kits,’ and I don’t think they understood at first what exact part of the supply chain we needed,” she said. “We needed extraction kits.”
An FDA spokesperson said that the agency is contacting labs that are testing for the coronavirus “to understand their supply issues and assist where we can.”
The FDA has also approved a change to the CDC diagnostic test that allows labs to switch from Qiagen’s RNA extraction method to another manufactured by Roche, says Denny Russell, who leads the coronavirus response at Washington state’s public health lab. But getting his lab ready to use the Roche method could take a week in part because technicians will need training to use it.
Commercial labs, which have recently started running coronavirus tests, have not experienced any supply shortages, according to a spokesperson for the American Clinical Laboratory Association.
In the meantime, Qiagen has told customers that it may not be able to fill large standing orders, because it is trying to provide smaller numbers of kits to as many labs as possible, said spokesperson Robert Reitze. The company is ramping up production of RNA extraction kits at manufacturing sites in Hilden, Germany; Barcelona, Spain; and Germantown, Md.
Nancy Cook and Dan Goldberg contributed to this report.
Life and it’s increasing COMPLEXITIES!
ONLY Experienced & Open Mindsets can deal with The Fury!
DIFFERENT STROKES FOR DIFFERENT FOLKS
World Health Organization declares coronavirus a pandemic
From CNN Health’s Jamie Gumbrecht
Credit: NIAID-RML
Credit: NIAID-RML
The World Health Organization just declared the novel coronavirus outbreak to be a pandemic.
The novel coronavirus outbreak is the first pandemic caused by a coronavirus, WHO Director-General Tedros Adhanom Ghebreyesus said Wednesday.
Remember: CNN began calling the virus a pandemic e
20 min ago
20% of students across the world are out of school because of coronavirus
From CNN's Jonny Hallam
The United Nations estimates that the coronavirus crisis is now impacting close to 363 million students worldwide, according to data published by the UN Educational, Scientific and Cultural Organization.
Schools and colleges across the globe have closed — some moving to online only classes — to contain the spread of novel coronavirus.
“One in five students worldwide is staying away from school due to the COVID-19 crisis and an additional one in four is being kept out of higher education establishments,” according to UNESCO.
UNESCO says 15 countries have ordered nationwide school closures and 14 have implemented localized closures, spanning Asia, Europe, the Middle East and North America.
DIFFERENT STROKES FOR DIFFERENT FOLKS
https://cnn.it/38CJiOw
Great ADVICE from Dr OZ: been doing ALL of it since 1988 except for FLU Shots:
My result since 1988: NO need to see a doctor; NO prescriptions or medications; few if any sniffles; ideal BMI even slimmed down from 33 inch waist to 29 inch; have LOW Blood Pressure!
This has been a 30 plus year time tested quality of strong IMMUNE System
AND I recognized since 1988 the BANE/DOWNSIDES of Food co’s Health Care costs!
AND although no science background fairly good track record in land mine infested emerging biotechs;
I do spend LOTS of time reading many nutrition/ trade journals to CONTINUALLY IMPROVE my IMMUNE system along with NOURISHING the most important of all: Your Brain!!
Followup on RESTORING your stomach's natural bacteria for HEALTHY DIGESTION:
https://www.amazon.com/Clean-Gut-Breakthrough-Eliminating-Revolutionizing/dp/006207587X/ref=sr_1_4?crid=36GAWUSU9PJOG&keywords=dr.+alejandro+junger&qid=1581471657&sprefix=dr.+ale%2Caps%2C197&sr=8-4
Dr. OZ today:
Oz also highlighted important areas of focus when it comes to keeping your immune system strong: sleep, exercise, supplements and a healthy diet. Here are a few specific things you can do to stay healthy.
1. Take care of yourself.
Practice good sleep hygiene, exercise and try to mediate. Meditation can help to reduce stress on your immune system.
"Something as simple as a five-minute yoga tactic,'' he said. "Go sit on the toilet seat, put it down — you're not going to the bathroom — sit there, quiet yourself and just realize that it's OK. No one will bother you there."
2. Consider taking a vitamin D supplement.
Oz suggested adding a few supplements to boost your defenses against illness.
"Supplements have never been shown to beat coronavirus, however there are some tactics that will slow down the progression of viruses in general,'' he said. "So ideas that work well generally are vitamin D, which you get from the sun, but this time of year you've got to take it as a supplement."
He also recommended vitamin C, zinc and elderberry supplements, as well as getting vitamin C from healthy sources like leafy greens, salmon and berries.
3. Load up on healthy fruits and vegetables.
"Fruits and vegetables make a huge difference, they enhance your immune response," he noted. Oz shared some recipes for delicious and healthy smoothies that also pack in plenty of antioxidants for immune system health.
His "green energy machine" smoothieincludes spinach, matcha powder and almond milk, while his "ginger hydrator" drink features oranges, bananas and pineapple.
"The nice thing about this baby is that it's got all the antioxidants you'd ever want to have, and I think you'll like the taste," he said about the ginger hydrator.
4. Get the flu shot.
"That way if you feel ill, you know it's not the flu, most likely," Oz explained.
For those who are 60 and older and worried about the coronavirus, Oz shared risk factors people in that demographic should keep an eye on.
He also noted that he has been frequently asked by people whether they should avoid going out in public due to the coronavirus, and he urged people not to panic.
"Live your life,'' he said. "Do not live your life with fear. Live it with joy and kindness”
https://www.aol.com/article/lifestyle/2020/03/09/dr-oz-shares-4-ways-to-strengthen-your-immune-system/23945080/
LIFE is what YOU MAKE of IT!
DIFFERENT STROKES FOR DIFFERENT FOLKS
Coronavirus: Up to 70% of Germany could become infected - Merkel
Reuters
Chancellor Merkel addressed reporters alongside Health Minister Jens Spahn
German Chancellor Angela Merkel has warned that up to 70% of the country's population - some 58 million people - could contract the coronavirus.
Mrs Merkel made the stark prediction at a news conference on Wednesday alongside Health Minister Jens Spahn.
She said since there was no known cure, the focus would fall on slowing the spread of the virus. "It's about winning time," she explained.
Her remarks came as Italy entered its second day of a national lockdown.
Italian Prime Minister Giuseppe Conte announced the closure of schools, gyms, museums, nightclubs and other venues across the country, which on Wednesday passed 10,000 confirmed infections.
BBC
FOLLOW LIVE UPDATES
EASY STEPS: What can I do?
QUARANTINE: Could the US do what Italy has done?
A SIMPLE GUIDE: What are the symptoms?
IMMUNITY: Are women and children less affected?
MAPS AND CHARTS: Visual guide to the outbreak
VIDEO: The 20-second hand wash
What's happening elsewhere?
New York's governor announced that troops would be sent into New Rochelle, a town north of the city, in an attempt to contain an outbreak of the virus, as the total number of US cases passed 1,000 on Wednesday.
A one-mile (1.6km) containment zone was in force around New Rochelle - with all of those in the zone quarantined.
In Italy, which has seen a steep rise in cases, Mr Conte pledged 25bn euros ($22bn) to tackle the outbreak - up from the 7.5bn euros announced last week.
Music festivals and other major events, including Coachella festival in California, have been cancelled or postponed. Berlin city authorities on Wednesday banned all events with more than 1,000 participants.
Thousands of flights have been cancelled worldwide as airlines struggle to cope with a slump in demand.
A UK health minister, Nadine Dorries, said she had tested positive for coronavirus and was self-isolating at home.
China - where the virus was first detected - has seen a total of 80,754 confirmed cases and 3,136 deaths. But it recorded its lowest number of new infections, just 19, on Tuesday.
Third patient dies in Germany
Germany confirmed its third coronavirus-related death on Wednesday, in the badly affected district of Heinsberg in the western state of North Rhine-Westphalia.
The first fatality was an 89-year-old woman who died in the town of Essen, the second a 78-year-old man with pre-existing health conditions who died in Heinsberg.
Germany has so far reported 1,296 cases of the virus, according to figures released by the Robert Koch Institute (RKI) for disease control late on Tuesday. Lothar Wieler, the president of the RKI, said the body did not believe there was a significant number of undetected cases in the country.
Speaking alongside Mr Wieler at a press conference - her first public address on the outbreak - Chancellor Merkel warned that border closures would not be enough to prevent the spread of the virus. She ruled out following Austria's lead in banning visitors from Italy.
"This is a test for our solidarity, our common sense and care for each other. And I hope we pass the test," she said.
Mrs Merkel also said she was open to scrapping Germany's "black zero" rule to allow new government borrowing. She said it was "an extraordinary situation" and that ending the outbreak came first.
Wednesday also saw Berlin city authorities ban all events with more than 1,000 participants until the end of the Easter holidays.
"The coronavirus continues to spread. In such a phase, public life must be restricted," said the city's Health Minister, Dilek Kalayci. "The spread of the coronavirus can be slowed down by reducing major events. At the beginning of an epidemic, such a restriction is important."
DIFFERENT STROKES FOR DIFFERENT FOLKS
LASER FOCUSED in USA versus errant crickets:
Quote:
New York has the most Covid-19 infections in the U.S., as of Monday afternoon
https://benzinga.com/z/15513760#.XmcZ81R0I34.mailto
Quote:
Tri-State COVID-19 Cases Triple Since Friday; NJ Declares State of Emergency
Quote:
The number of novel coronavirus cases in the tri-state area surged by 216 percent between late Friday and Monday afternoon, from 49 cases to 156
New York was up to at least 143 cases statewide, 20 of them in the five boroughs, as of Monday evening; the lion's share of those cases are in Westchester County
New Jersey had 11 positive samples that had been sent to the CDC for confirmation, and Gov. Murphy declared a state of emergency; Connecticut saw its second presumptive positive as well
https://www.nbcnewyork.com/news/local/brooklyn-sees-1st-coronavirus-cases-as-tri-state-total-surges-136-in-3-days-some-schools-close/2317966/
Temperature sensitivity of Corona Virus re China experts:
https://www.inkstonenews.com/health/coronavirus-highly-sensitive-high-temperatures-study-says/article/3074204
DIFFERENT STROKES FOR DIFFERENT FOLKS
From the FRONT LINES The crystallization of USA issues with COVID 19 versus others: DISGRACEFUL!
As of Feb. 26, CDC had performed a total of 445 tests. For comparison, the UK, with a population five times smaller than the US, had conducted over 7,000 tests.
March 2, 2020
Dr. Matt McCarthy, a staff physician at New York-Presbyterian:
“I’m here to tell you, right now, at one of the busiest hospitals in the country, I don’t have [a rapid diagnostic test] at my finger tips.” “I still have to make my case, plead to test people. This is not good. We know that there are 88 cases in the United States. There are going to be hundreds by middle of week. There’s going to be thousands by next week. And this is a testing issue.”
“In New York State, the person who tested positive is only the 32nd test we’ve done in this state,” he said. “That is a national scandal. [...] They’re testing 10,000 a day in some countries and we can’t get this off the ground,” McCarthy said. “I’m a practitioner on the firing line, and I don’t have the tools to properly care for patients today.” (Video, CNBC)
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Instructive for ALL high profile prolific posters from a REAL expert versus babbling brook The Science from an Expert an EPIDEMIOLOGIST PRECLUDES errant misguided ways:
Quote:
Why this epidemiologist is more worried about coronavirus than he was a month ago
Maciej F. Boni
Americans need to prepare themselves that the next 12 months are going to look very different.
By Maciej F. Boni
Americans need to prepare themselves that the next 12 months are going to look very different.
Passengers get off a New York City subway on March 7.
The Harvard historian Jill Lepore recounted recently in The New Yorker magazine that when democracies sink into crisis, the question “where are we going?” leaps to everyone’s mind, as if we were waiting for a weather forecast to tell us how healthy our democracy was going to be tomorrow. Quoting Italian philosopher Benedetto Croce, Lepore writes that “political problems are not external forces beyond our control; they are forces within our control. We need solely to make up our own minds and to act.”
And so it is with the coronavirus epidemic. How big will this epidemic be? How many people will it infect? How many Americans will die? The answers to these questions are not written in stone. They are partially within our control, assuming we are willing to take the responsibility to act with commitment, urgency and solidarity.
I am an epidemiologist with eight years of field experience, including time on the front lines of the isolation and quarantine efforts during the 2009 swine flu pandemic. One month ago, I was under the impression that the death reports due to COVID-19 circulation in China were giving us an unfair picture of its mortality rate. I wrote a piece saying that the death rate of an emerging disease always looks bad in the early stages of an outbreak, but is likely to drop once better data become available. After waiting for eight weeks, I am now worried that these new data — data indicating that the virus has a low fatality rate — may not arrive.
Case fatality rate and infection fatality rate
By Jan. 31, China had reported a total of 11,821 cases of COVID-19 and 259 deaths; that’s about a 2% case fatality rate. Two weeks later, the tally had risen to more than 50,000 cases and 1,524 deaths, corresponding to about 3% case fatality (the rise in the case fatality is expected as deaths always get counted later than cases). For an easily transmissible disease, a 2% or 3% fatality rate is extremely dangerous.
However, case fatality rates are computed using the officially reported numbers of 11,821 cases or 50,000 cases, which only include individuals who (a) experience symptoms; (b) decide that their symptoms are bad enough to merit a hospital visit; and (c) choose a hospital or clinic that is able to test and report cases of coronavirus.
Surely, there must have been hundreds of thousands cases, maybe a million cases, that had simply gone uncounted.
First, some definitions from Steven Riley at Imperial College. The infection fatality rate (IFR) gives the probability of dying for an infected person. The case fatality rate (CFR) gives the probability of dying for an infected person who is sick enough to report to a hospital or clinic. CFR is larger than IFR, because individuals who report to hospitals are typically more severely ill.
If China’s mid-February statistic of 1,524 deaths had occurred from 1 million infections of COVID-19 (counting all symptomatic and asymptomatic infections), this would mean that the virus had an infection fatality rate of 0.15%, about three times higher than seasonal influenza virus; this is a concern but not a crisis.
After waiting for eight weeks, I am now worried that data indicating the virus has a low fatality rate may not arrive.
The IFR is much more difficult to estimate than the CFR. The reason is that it is hard to count people who are mildly ill or who show no symptoms at all. If you are able to count and test everybody — for example, on a cruise ship, or in a small community — then you may be able to paint a picture of what fraction of infections are asymptomatic, mild, symptomatic and severe.
Scientists working at the London School of Hygiene and Tropical Medicine, Imperial College London and the Institute for Disease Modeling have used these approaches to estimate the infection fatality rate. Currently, these estimates range from 0.5% to 0.94% indicating that COVID-19 is about 10 to 20 times as deadly as seasonal influenza. Evidence coming in from genomics and large-scale testing of fevers is consistent with these conclusions. The only potentially good news is that the epidemic in Korea may ultimately show a lower CFR than the epidemic in China.
Impact of the epidemic in the U.S.
Now that new COVID-19 cases are being detected in the U.S. every day, it is too late to stop the initial wave of infections. The epidemic is likely to spread across the U.S. The virus appears to be about as contagious as influenza. But this comparison is difficult to make since we have no immunity to the new coronavirus.
On balance, it is reasonable to guess that COVID-19 will infect as many Americans over the next year as influenza does in a typical winter — somewhere between 25 million and 115 million. Maybe a bit more if the virus turns out to be more contagious than we thought. Maybe a bit less if we put restrictions in place that minimize our travel and our social and professional contacts.
The bad news is, of course, that these infection numbers translate to 350,000 to 660,000 people dying in the U.S., with an uncertainty range that goes from 50,000 deaths to 5 million deaths. The good news is that this is not a weather forecast. The size of the epidemic, i.e., the total number of infections, is something we can reduce if we decrease our contact patterns and improve our hygiene. If the total number of infections decreases, the total number of deaths will also decrease.
What science cannot tell us right now is exactly which measures will be most effective at slowing down the epidemic and reducing its impact. If I stop shaking hands, will that cut my probability of infection by a half? A third? Nobody knows. If I work from home two days a week, will this reduce my probability of infection by 40%? Maybe. But we don’t even know the answer to that.
What we should prepare for now is reducing our exposures — i.e., our chances of coming into contact with infected people or infected surfaces — any way that we can. For some people this will mean staying home more. For others it will mean adopting more stringent hygiene practices. An extreme version of this exposure reduction — including mandatory quarantine, rapid diagnosis and isolation, and closing of workplaces and schools — seems to have worked in Hubei province in China, where the epidemic spread appears to have slowed down.
For now, Americans need to prepare themselves that the next 12 months are going to look very different. Vacations may have to be canceled. Social interactions will look different. And risk management is something we’re going to have to think about every morning when we wake up. The coronavirus epidemic is not going to extinguish itself. It is not in another country. It is not just the cold and flu. And it is not going away.
Maciej F. Boni is as associate professor of biology at Pennsylvania State University in State College, Pa. This was first published on The Conversation — “How big will the coronavirus epidemic be? An epidemiologist updates his concerns”
https://counter.theconversation.edu.au/content/133133/count.gif
RELATED: When does a coronavirus epidemic become a pandemic? When does a coronavirus epidemic become a pandemic?
RELATED: Deadly viruses are no match for plain old soap — here’s the science behind it Deadly viruses are no match for plain old soap — here’s the science behind it
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http://www.marketwatch.com/story/why-this-epidemiologist-is-more-worried-about-coronavirus-than-he-was-a-month-ago-2020-03-09
The level of so called Due Diligence is appalling IMHO.
DIFFERENT STROKES FOR DIFFERENT FOLKS
From the FRONT LINES The crystallization of USA issues with COVID 19 versus others: DISGRACEFUL!
As of Feb. 26, CDC had performed a total of 445 tests. For comparison, the UK, with a population five times smaller than the US, had conducted over 7,000 tests.
March 2, 2020
Dr. Matt McCarthy, a staff physician at New York-Presbyterian:
“I’m here to tell you, right now, at one of the busiest hospitals in the country, I don’t have [a rapid diagnostic test] at my finger tips.” “I still have to make my case, plead to test people. This is not good. We know that there are 88 cases in the United States. There are going to be hundreds by middle of week. There’s going to be thousands by next week. And this is a testing issue.”
“In New York State, the person who tested positive is only the 32nd test we’ve done in this state,” he said. “That is a national scandal. [...] They’re testing 10,000 a day in some countries and we can’t get this off the ground,” McCarthy said. “I’m a practitioner on the firing line, and I don’t have the tools to properly care for patients today.” (Video, CNBC)
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Instructive for ALL high profile prolific posters from a REAL expert versus babbling brook The Science from an Expert an EPIDEMIOLOGIST PRECLUDES errant misguided ways:
LASER FOCUSED in USA versus errant crickets:
FACTUALLY from REAL EXPERTS on CoronaVirus: COVID 19 VERSUS heresay which not surprisingly happens to be always DEVOID of LINKS; debate postmaster etc:
Umibe: Stupendous OVER the Top closing summation before TLD:
Likened to a wrecking ball: leaving little to no oxygen for the bowled over skeptics
who may still need Iwasadiver to add his NYC skyscraper wrecking ball!
After 5 + years for many of SOLITARY confinement in one stock:
Anxiously awaiting being UNSHACKLED!
BTW Superb coverage/sleuthing by Lyricki/Longfellow series of posts re 17 acre left Sawston site
DIFFERENT STROKES FOR DIFFERENT FOLKS
COVID 19: NPR Here&Now 3/2/20 morning Radio Interview w/former Sec of HHS Kathleen Sebelus:
Finally a delayed link ( since this interview 4 more Seattle deaths=6: happened in a nursing home! (older people more susceptible!) Accounts for all the USA deaths
City of booming Seattle(where I lived; last few yrs has had more construction cranes each year than the Next 3 USA cities COMBINED! City of Seattle has bought a Motel to deal with burgeoning COVID 19 issues!
https://www.wbur.org/hereandnow/2020/03/02/health-us-covid-19-coronavirus
DIFFERENT STROKES FOR DIFFERENT FOLKS
The "complete" basics on Maverick_1 previously posted:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=144839547
As for:
Listened to just ended NPR Here & Now:
Insightful, NO nonsense & comprehensive interview of Kathleen Sebelius former HHS re world’s leading expert on Infectious Diseases: Dr Tony Fauci( last week said not till NEXT year under control);Trump Politics; VP Pence; we are behind the curve; did not help that CDC funding was drastically reduced last two years by Trump! Covid19 will grow this Spring etc
Re Undertaking the Coronavirius (Covid 19).
NO link too recent
BELATEDLY DMiller is being recognized over The HERD!
DIFFERENT STROKES FOR DIFFERENT FOLKS
I was employed by Cowen in 1980-1985 when they had one of the best Health Care; Technology; and Defense
research teams on Wall St then : re Cowen’s NEW Buy Recommendation today with a $51 price target
https://www.streetinsider.com/dr/news.php?id=16552196
https://thefly.com/landingPageNews.php?id=3042747&headline=AMRN-Amarin-initiated-with-an-Outperform-at-Cowen and AMRN appearing today at Cowen's 39th Annual Health Care Conference.
Cowen becomes the 12th Wall St firm to cover Amarin:
https://investor.amarincorp.com/analyst-coverage
OECD: Coronavirus: Global growth ‘could halve’ if outbreak intensifies
A "longer lasting and more intensive" outbreak could halve growth in 2020, says the OECD.
Disclaimer: The BBC
I have only offered constructive commentary on any msg bds: receded dramatically in last 6 months due to
“Oil does not mix with water: retail vs Institutional mindset differences”
AND many more critical time consuming endeavors in keeping abreast of the Investment scene!
DIFFERENT STROKES FOR DIFFERENT FOLKS
BEST single eye POPPING DAILY site re COVID 19 developments in a nutshell IMHO & supplemented by CNN et al:
:
https://www.worldometers.info/coronavirus
BTW I have been tracking the Corona Virus since close to it's inception:
Expected HUGE market impact as shutting down and isolating cities especially in China would have MASSIVE worldwide repercussions as China HAS BEEN RESPONSIBLE for a LARGE part of the world's economic recovery from the massive financial collapse.
Add to that the relentless downgrades previously by the IMF on world GDP due to Trump's Tariffs wars with China; the success of TSLA's EV's being leaps and bounds ahead of ALL their peers and close to 9 mln worldwide auto assembly workers doing internal combustion engines and it's attendant multiplier supply chain effectS; AND down the road: FASTER depreciation on existing gasoline cars.
There will be loads of China defaults in the coming months as those loans come due!.
The WW banking system will be STRAINED: on top of lower births in US/China ; BreExit ETC ETC Black SwanS
Even more Dramatic slowdown in Global Economic activity which was already faced many IMF growth reductions since Trump Tariff Wars began will be realized IMHO.
COMPLICATING the ABOVE are Trumps POOR judgements of my way or the highway (I am not a registered voter and turning 71!):
https://www.rawstory.com/2020/02/cdc-employees-demoralized-over-trump-interference-as-they-grapple-with-coronavirus-crisis-cnn/
Growing litany of articles citing WW economic impact from COVID 19:
https://www.nytimes.com/2020/02/29/upshot/coronavirus-recession-US.html
BEGINNINGECONOMIC IMPACT from COVID19:
China factory activity shrank at its fastest rate on record in February
PUBLISHED FRI, FEB 28 20209:45 PM ESTUPDATED FRI, FEB 28 20209:55 PM EST
Reuters
KEY POINTS
China’s official Purchasing Managers’ Index (PMI) fell to a record low of 35.7 in February from 50.0 in January.
The data highlight the damage from the coronavirus outbreak on the world’s second-largest economy.
The results suggest deepening cracks in an economy already hit by the trade war.
What does the coronavirus mean for China’s economy?
Factory activity in China contracted at the fastest pace on record in February, highlighting the damage from the coronavirus outbreak on the world’s second-largest economy.
China’s official Purchasing Managers’ Index (PMI) fell to a record low of 35.7 in February from 50.0 in January, the National Bureau of Statistics said on Saturday, well below the 50-point mark that separates monthly growth from contraction. Analysts polled by Reuters expected the February PMI to come in at 46.0.
The somber readings provide the first official snapshot of the state of the Chinese economy since the outbreak of the coronavirus epidemic which has killed almost 3,000 people in mainland China and infected about 80,000.
The results suggest deepening cracks in an economy already hit by the trade war as the coronavirus forces widespread transport curbs and tough public health measures which have paralyzed economic activity.
China’s economy is widely expected to suffer another sharp blow in the first quarter of this year, pressuring policymakers to unveil more stimulus measures.
Nomura expects first-quarter growth to be at 2.0% year-on-year while Capital Economics estimates China’s economy would contract outright in year-on-year terms this quarter, for the first time since at least the 1990s.
GP 200229 china pmi factory
Workers work at a vehicle chair manufacture factory in Lintong District of Xi’an, northwest China’s Shaanxi Province, Feb. 26, 2020.
Xinhua | Liu Xiao | Getty Images
A sub-index of manufacturing production nosedived to 27.8 in February from January’s 51.3 while a reading of new orders plunged to 29.3, down from 51.4 a month earlier.
Factories continued to lose jobs at the fastest pace in years as labor conditions remained tight amid the travel restrictions.
China’s leaders have urged local governments, factories and workers to re-start operations as soon as possible in less affected regions. But the response has been slow and many migrant workers — including those in worst-hit Hubei province — have yet to return to work due to stringent quarantine rules and ongoing travel bans.
Official data showed that only about 30% of China’s small- and medium-sized companies had resumed production as of Wednesday. Some firms that have restarted work are reportedly running below normal capacity.
Small- and mid-size firms account for more than 80% of nationwide employment and over 60% of gross domestic product.
Global outbreak could prolong China’s pain
As the coronavirus spreads to more countries, some analysts have warned that the impact on global supply chains could risk dampening the subsequent recovery for Chinese manufacturers.
“Even if labor shortages in China start to ease, some factories may run into problems resuming normal production if outbreaks in other countries mean they have trouble sourcing intermediate goods,” Julian Evans-Pritchard, senior China economist at Capital Economics, said in a note on Friday.
Economists at Morgan Stanley have warned of a pronounced impact on first-quarter global growth, with rising risks of it extending into the second quarter this year.
China’s services sector activity also posted the deepest contraction on record, with official non-manufacturing PMI dropping to 29.6, from 54.1 in January, a separate NBS survey showed.
China’s economy has transitioned more towards services since the SARS coronavirus epidemic in 2002-2003, and the sector now accounts for about 60% of the country’s Gross Domestic Product (GDP).
Transportation, tourism, catering and entertainment sectors have been hard hit during the coronavirus outbreak as people avoid crowded areas.
A sub-index of construction activity, a key driver of growth, stood at 26.6, down from 59.7 in January.
Expecting MORE collateral damage to China's economy and Europe's courtesy of BIG Chinese DEBTS DUE that may have Domino Effects. WW Banking System resources will be tested IMHO.
When so much of the world has been dependent on low cost mfg AND GROWTH from and in China (ie Starbucks has 4,000 stores there and is SBUX's 2nd largest market next to US; 70% of all shoes bought in US is made in China!; China is the world's computer hardware and micro electronics capital etc) and their awakening from the Sleeping Giant since 1990's and the US's
These TWO samplerS are a MUST READ:
https://www.cnbc.com/2019/07/15/mckinsey-world-has-become-more-exposed-to-china-but-not-the-reverse.html
https://www.nytimes.com/2020/01/29/business/china-coronavirus-economy.html
SO INVESTORS doing their Due Diligence should NOT have been SURPRISED BY THE WORLDWIDE STOCK MARKET MELTDOWNS
CDC did NOT have the adequate COVID19 test kits nor the volume needed: only by end of next week.
TO WIT:
Japan is closing ALL it's schools for A MONTH
China's quarantine resulting in this: https://oilprice.com/Energy/Crude-Oil/Chinas-Floods-The-Market-With-Fuel-As-Coronavirus-Shatters-Local-Demand.html
Update COVID 19 growing FASTEST OUTSIDE China: there are 60 countries of 195 with confirmed cases I
AND EYE popping single best source IMHO:
https://www.worldometers.info/coronavirus
AND in the USA: first death::
8 min ago
Investigation into US coronavirus death suggests person became ill through community spread
From CNN Health’s Jamie Gumbrecht
The Washington woman who died from the novel coronavirus appears to have become ill through community spread, says Dr. Robert Redfield, director of the US Centers for Disease Control and Prevention.
“The investigation at this time shows no evidence of link to travel or a known contact,” Redfield told reporters at the White House on Saturday.
Trump said there are now 22 cases of the novel coronavirus in the United States. That number does not include individuals repatriated to the United States from Wuhan, China, or from the Diamond Princess cruise ship. Those cases have been counted separately by the CDC.
COVID 19 cases by Country:
https://www.cdc.gov/coronavirus/2019-ncov/locations-confirmed-cases.html
ALARMING how many countries have confirmed cases: largely plane travel; cruise ship and worst: "community spread"
Italy #1 in Europe 1200 cases
Germany now has 48 cases, making it the second most infected European country after Italy.
Looks like ALL of pre COVID19 Europe was on edge of recession AND WORST NOW w/Covid19 with
SHAKY FINANCES: NEGATIVE INTEREST RATES!
BEGINNING ECONOMIC IMPACT:
China factory activity shrank at its fastest rate on record in February
PUBLISHED FRI, FEB 28 20209:45 PM ESTUPDATED FRI, FEB 28 20209:55 PM EST
Reuters
KEY POINTS
China’s official Purchasing Managers’ Index (PMI) fell to a record low of 35.7 in February from 50.0 in January.
The data highlight the damage from the coronavirus outbreak on the world’s second-largest economy.
The results suggest deepening cracks in an economy already hit by the trade war.
What does the coronavirus mean for China’s economy?
Factory activity in China contracted at the fastest pace on record in February, highlighting the damage from the coronavirus outbreak on the world’s second-largest economy.
China’s official Purchasing Managers’ Index (PMI) fell to a record low of 35.7 in February from 50.0 in January, the National Bureau of Statistics said on Saturday, well below the 50-point mark that separates monthly growth from contraction. Analysts polled by Reuters expected the February PMI to come in at 46.0.
The somber readings provide the first official snapshot of the state of the Chinese economy since the outbreak of the coronavirus epidemic which has killed almost 3,000 people in mainland China and infected about 80,000.
The results suggest deepening cracks in an economy already hit by the trade war as the coronavirus forces widespread transport curbs and tough public health measures which have paralyzed economic activity.
China’s economy is widely expected to suffer another sharp blow in the first quarter of this year, pressuring policymakers to unveil more stimulus measures.
Nomura expects first-quarter growth to be at 2.0% year-on-year while Capital Economics estimates China’s economy would contract outright in year-on-year terms this quarter, for the first time since at least the 1990s.
GP 200229 china pmi factory
Workers work at a vehicle chair manufacture factory in Lintong District of Xi’an, northwest China’s Shaanxi Province, Feb. 26, 2020.
Xinhua | Liu Xiao | Getty Images
A sub-index of manufacturing production nosedived to 27.8 in February from January’s 51.3 while a reading of new orders plunged to 29.3, down from 51.4 a month earlier.
Factories continued to lose jobs at the fastest pace in years as labor conditions remained tight amid the travel restrictions.
China’s leaders have urged local governments, factories and workers to re-start operations as soon as possible in less affected regions. But the response has been slow and many migrant workers — including those in worst-hit Hubei province — have yet to return to work due to stringent quarantine rules and ongoing travel bans.
Official data showed that only about 30% of China’s small- and medium-sized companies had resumed production as of Wednesday. Some firms that have restarted work are reportedly running below normal capacity.
Small- and mid-size firms account for more than 80% of nationwide employment and over 60% of gross domestic product.
Global outbreak could prolong China’s pain
As the coronavirus spreads to more countries, some analysts have warned that the impact on global supply chains could risk dampening the subsequent recovery for Chinese manufacturers.
“Even if labor shortages in China start to ease, some factories may run into problems resuming normal production if outbreaks in other countries mean they have trouble sourcing intermediate goods,” Julian Evans-Pritchard, senior China economist at Capital Economics, said in a note on Friday.
Economists at Morgan Stanley have warned of a pronounced impact on first-quarter global growth, with rising risks of it extending into the second quarter this year.
China’s services sector activity also posted the deepest contraction on record, with official non-manufacturing PMI dropping to 29.6, from 54.1 in January, a separate NBS survey showed.
China’s economy has transitioned more towards services since the SARS coronavirus epidemic in 2002-2003, and the sector now accounts for about 60% of the country’s Gross Domestic Product (GDP).
Transportation, tourism, catering and entertainment sectors have been hard hit during the coronavirus outbreak as people avoid crowded areas.
A sub-index of construction activity, a key driver of growth, stood at 26.6, down from 59.7 in January.
Expecting MORE collateral damage to China's economy and Europe's courtesy of BIG Chinese DEBTS DUE that may have Domino Effects. WW Banking System resources will be tested IMHO.
When so much of the world has been dependent on low cost mfg AND GROWTH from and in China (ie Starbucks has 4,000 stores there and is SBUX's 2nd largest market next to US; 70% of all shoes bought in US is made in China!; China is the world's computer hardware and micro electronics capital etc) and their awakening from the Sleeping Giant since 1990's and the US's
These TWO samplerS are a MUST READ:
https://www.cnbc.com/2019/07/15/mckinsey-world-has-become-more-exposed-to-china-but-not-the-reverse.html
https://www.nytimes.com/2020/01/29/business/china-coronavirus-economy.html
SO INVESTORS doing their Due Diligence should NOT have been SURPRISED BY THE WORLDWIDE STOCK MARKET MELTDOWNS
CDC did NOT have the adequate COVID19 test kits nor the volume needed: only by end of next week.
That's why I finally buckled and elected to sacrifice myself here to ONE POST per Day FOR INFINITY:
To devote to many MORE critical issues! GIVEN the EVIDENCE faced here since 2015! even with what I sensed since my earliest posts beginning mid 2014.
DIFFERENT STROKES FOR DIFFERENT FOLKS
Coronavirus unlikely to vanish NEXT Year re NIH Dr Tony Fauci!
FEBRUARY 28, 2020 / 03:49 PM / UPDATED 3 MINUTES AGO
Coronavirus unlikely to vanish next year-NIH's Fauci according to source
WASHINGTON, Feb 28 (Reuters) - A senior U.S. health official told lawmakers that the coronavirus that is spreading globally is unlikely to disappear next year and that many more cases should be expected in the United States, according to a source who attended a briefing on Friday.
Anthony Fauci, who heads the National Institute of Allergy and Infectious diseases, also told House of Representatives members in a closed briefing that the United States currently does not have enough coronavirus testing resources.
Reporting by Richard Cowan Editing by Chizu Nomiyama
————————————————-
Airlines Cancel Flights To Italy As Coronavirus Hampers Demand re Forbes
Topline: European airlines are cancelling flights to Italy, which has in recent days become a coronavirus hot spot in Europe, in the latest sign of the strain the aviation industry is under as Covid-19 spreads globally.
———————————————-
For your enjoyment JL:
Tesla Model S Competes Against Hybrid Acura NSX: Electric Vs Hybrid
It is time for the “Tesla Model S Vs Acura NSX.” Don’t make any mistakes, it is an important drag race battle between an electric car and a Hybrid vehicle. Brooks from “DragTimes” uploaded a video of a drag race between these two monsters of green and sustainable energy and we are here to talk […] The post Tesla Model S Competes Against Hybrid Acura NSX: Electric Vs Hybrid appeared first on Fossbytes.
Read in Fossbytes:
Tesla Model S vs Acura NSX Drag Race
DIFFERENT STROKES FOR DIFFERENT FOLKS
TRULY REFRESHING for a CHANGE to have MORE Company with posters with REAL demonstrated relevant experience on this board as well as for being BOLD and sharing your viewS which I previously expressed to hyperopia:
5.0 mln 4Q’19 Purchases of Baker Bros 7.0 mln sold 4Q’19 accounted for so far:
Artisan & Farallon apparently bought in Dec 4qtr 5.0 mln of the 7.0 mln Baker Bros 7 mln 4qtr sold:
https://www.nasdaq.com/market-activity/stocks/amrn/institutional-holdings
Different Strokes for Different Folks
Update UCSF re GBM:
Brain tumor surgery that pushes boundaries boosts patients survival
Control person deploying a TRIFECTA of wonders?:
Raising ~$1 mln via modest reduction in INMB % ownership to
for a more timely & get NWBO shares rolling for a massively larger return envisioned in NWBO achieving this:
1)Remove the possible overhang of that 5 mln NWBO (suggested by Sojourner55 & Hbpainter conjecture
of unsold Woodford holdings!
2)Give vital market support with CEO insider buying
3) BEGIN the redirection for a procession of events leading to an incoming tsunami re TLD
My sense: Clearly this would be a much better REdeployment of her money IMHO that performs ALL of the above vs INMB.
As for LP’s wts: that can wait
Thanks Umibe for sharing most of the details of your SVP Les Goldman’s recent conversation.
FYI: re Marzan VASCEPA Scripts (BasinStBlues request re Bloomberg terminal access)
MKT for TWO months NOT REACTING to Dec CC and Nov CEO Suen 900K buy at 35 cts
Despite over a month since CEO Suen did this:
https://finance.yahoo.com/news/weyland-tech-ceo-discuss-company-133110627.html
AND
Bought 900K shs in a private transaction in late Nov 2019 FRONT RUNNING the above acquisition in Dec 2019 :
https://www.globenewswire.com/news-release/2019/11/19/1949442/0/en/Weyland-Tech-President-and-CEO-Purchases-900-000-Shares-of-Company-Stock.html
Still PERPLEXED as many here!
WEYL has DECLINED since late NOV 2019 from 50+ cts to 35 cts!:
https://stockcharts.com/freecharts/gallery.html?weyl
ALL of the above has NOT deterred me from my forthright INITIAL view yearS ago of AVOIDING.
Since Nov had a few issues I came up with on my own going UP 300% plus.
BEST STRATEGIC Summary (without getting lost in the weeds, trees or forest) IMHO in consideration of:
THE Death by a Thousand Cuts here since 2015:
The NWBO TEAM survives many emergency rare blood transfusions due to many mortal wounds and becomes STRONGER!
Thanks Gary for your COMPLETE composite, few here have been able to muster all through this EPIC SAGA!
NOTE: Re edited & re posted from midnight post.
Re:
Although NWBO “investors” may believe in the yet to be decided
Efficacy Quality of Life by the Powers to be by FDA regulations in DC VAX L Ph 3 trial and three other Regulatory Authorities.....
What can be said DEFINITIVELY is that way too many since 2015 have been somewhat Financially ILLITERATE as to financial Options available to CEO Linda Powers obviously to her background as a deal maker re her Venture Capital background over a few DECADES to do what WhosleftholdingtheBag ascribes in the not surprising awarding to RE- pricing lower of various WRTS to solve NWBO current short term funding needs.
Lots of investors here are undergoing an expensive stressful yearS since 2015 of an EPIC Saga of dealing with all the land mines endemic to emerging biotechs which is why hedges re Adam Feurerstein do have on balance an enviable record with their growing gold mine.
IF “investors” complied with Feb 2919 PLEADS to get YOUR NWBO shares in your OWN Name which I had to REINFORCe, INHO what CEO Linda Powers would NOT had to do what WhosleftholdingtheBag cites below IMHO.
Betting against CEO Linda Powers is NOT the right strategy as timehas witnessed in last 2-3 years!
Onward & Forward IMHO to:
“From Near ASHES TWICE to The PHOENIX
BOTH CEO Linda Powers and UCLA’s Dr.Linda Phd MBA will be HERALDED
as Pioneering Women with a Legacy!
Thanks WhosleftholdingtheBag for:
Integrity, Backbone and TRUE GRIT from RRRIchmond when you do a cursory on his previous posts in 2015!
RE:
GREAT insightful; fortifying and comforting posts today by Iwasadiver(especially); Umibe; DocLogic ; Trocproftit; Marzan for TRUE Longs today that are a MUST READ & NOT overly perturbed by TDL delays; or
HOW we get to SANE valuations (a KEY was what CEO Linda Powers stated Feb 2019 and I REINFORCED: GET YOUR shares in YOUR OWN NAME which few seemed to understand:
IMHO EGO! Density; INEXPERIENCE got the better of most here vs the greater good for ALL! let alone DO! IF that was complied to: Do NOT think we've be where we are AS the exercise of below 30 cts warrants would have "been a taken care of drought and provided captive internal funding"
AND those who join me in continuing to ADD shares: THANKS!
ALL IMHO!
LOTS of relevant GBM news that I digested just today: see below (Why I've consistently mention whereas some spend their 24/7/365 on this one stock or a few stocks, for me in the last 40 yrs of 70 yrs, there is NEVER enough time in one's day to deal with the REAL WORLD NEWS on so many fronts that is ULTRA DYNAMICALLY CHANGING at ever increasing velocity rates!
One needs to keep vigilant by reading sorting, and digesting REAL RELEVANT INDUSTRY NEWS ; keeping an OPEN mind vs resting on one's laurels which has demonstrably proven so far financially disastrous for 99% of those here whether posting or LURKING.
Not in any order of priority:
What Manibiotech suggests does NoT have ANY basis!
Re:
Likely refutation of no imaging technology for T Cells:
Re Manibiotech:
CEO Missling last insider purchases (Mar 2018) were MODEST +5K shs and below $3:
https://www.nasdaq.com/market-activity/stocks/avxl/insider-activity
WHY didn't Missling buy <$1.60 late Dec 2018?
The above is confirmed on SEC 14D Proxy Filinghttps://secfilings.nasdaq.com/filingFrameset.asp?FilingID=13183181&RcvdDate=1/31/2019&CoName=ANAVEX%20LIFE%20SCIENCES%20CORP.&FormType=PRE%2014A&View=html
Everyone should have been aware of:
deepcapture.com
Which I posted here to your AVXL/NWBO moderator:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=103842106AND
Based on today's 12/11/2019 CLOSE AVXL is 7th ON the SHAME list of
STKS on ALL MARKETS: FIVE CONSECUTIVE TRADING DAYS DECLINE:
https://www.barchart.com/stocks/performance/five-day-gainers/declines
Recurring Dilution in place prior to 2021 completion of Anavex 2-73 with ATM partner Lincoln Park Capital:
https://secfilings.nasdaq.com/filingFrameset.asp?FilingID=13642818&RcvdDate=9/13/2019&CoName=ANAVEX%20LIFE%20SCIENCES%20CORP.&FormType=424B5&View=html
ALL is taking place IN SPITE OF:
https://ih.advfn.com/stock-market/NASDAQ/anavex-life-sciences-AVXL/stock-news/81280997/anavex-life-sciences-presents-anavex-2-73-blarcame
I sold AVXL many years ago@>$10 and NEVER thought of reacquiring.
This event likely caused AVXL’s recent drop IMHO:
Lots of “HIDDEN” Landmines in Emerging BioTechs! which are
aptly rated as Unsuitable for the NON adept
ACADIA Pharmaceuticals(ACAD) Presents Positive Top-line Results from Pivotal Phase 3 HARMONY Trial of Pimavanserin in Patients with Dementia-Related Psychosis at 12th Clinical Trials on Alzheimer’s Disease (CTAD) Meeting
- Pimavanserin met the primary endpoint in the study, significantly reducing the risk of relapse of psychosis by 2.8 fold (Hazard Ratio (HR)=0.353, one-sided p=0.0023)
- Pimavanserin met the key secondary endpoint in the study, significantly reducing the risk of discontinuation for any reason by 2.2 fold (HR=0.452, one-sided p=0.0024)
- Currently, there is no FDA-approved drug for the treatment of dementia-related psychosis
- Webcast to be held today at 7:15 p.m. Pacific Time
December 04, 2019 08:45 PM Eastern Standard Time
AND
When will we see AVXL on this SHAME list:
https://www.barchart.com/stocks/performance/five-day-gainers/declines
This stuff in your blood may cause inflammation, damage kidneys and blood vessels
Doctors interested in ways to minimize the risk of heart disease have long had blood cholesterol levels in their sights.
But other types of blood fats (also known as ‘lipids’) can also be damaging to health.
In a new study, researchers found high levels of a special group of lipids, triglycerides, could cause inflammation and damage kidneys and blood vessels.
The research was conducted by a team at Saarland University.
The team was able to demonstrate that patients with elevated levels of triglycerides in their blood had a much higher mortality rate than comparison groups with a similar health history.
They found that when these naturally occurring fats are at high levels, they can alter the body’s defense cells in such a way that the body reacts as if responding to a bacterial infection.
This leads to inflammation, which, if it becomes chronic, can damage the kidneys or cause atherosclerosis—the narrowing of arteries due to a build-up of deposits on the inner arterial wall.
And atherosclerosis is one of the main causes of heart attacks and strokes.
The study established a definitive link between the chronic inflammation triggered by a high triglyceride level in the blood and secondary diseases such as kidney failure or heart attack.
The team says that adopting a low-fat diet can strongly extend the life expectancy of high-risk patients, such as those with diabetes or those whose blood pressure is too high.
Blood triglyceride levels rise substantially in people who eat a high-fat diet.
The researchers hope that their results will help in developing new strategies for treating and preventing these life-threatening diseases.
The lead author of the study is Timo Speer.
The study is published in Nature Immunology.
Dr.Carlo Rago (@rago_carlo)
12/9/19, 3:54 PM
$NWBO #GBM
Full article showing [mOS of 35.9 months here:
ncbi.nlm.nih.gov/pmc/articles/P…
=========================
Dr. Carlo Rago (@rago_carlo)
12/9/19, 3:31 PM
$NWBO expectations
"If we include only those who received the DC vaccine in the newly diagnosed setting (n=15), the median overall survival is 35.9 months, with a mean follow-up time of over four years, and one, two and three-year survival rates of 93%, 77% and 58%,respectively."
pic.twitter.com/ZPWGUOJpVY
RE: Lot’s of recurring (non stop?) bamboozling grandstanding NONSENSE today lead by RECALCITRANTS
serve no constructive purpose!