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Correction. KRTX jumped huge with phase 2 results in Nov, 2019. They raised huge sum of money after that.
In this space, good phase 2 results could yield big time just because of the promise.
-vg_future
Wow! A jump. Much needed, much deserved and of course long awaited.
-vg_future
TempePhil, thanks for checking with the IR and providing us the confirmation. That puts an end to all negative speculation.
vg_future
Okay, got it. I am hoping (rather betting) that changes this summer or before.
JMHO,
vg_future
Agreed. Also, as Biostockclub has posted from RETT agency, until otherwise explicitly mentioned or reached out to, patients in trials should continue the treatment as per plan. I would assume the same would be the case in other ongoing trials.
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=154336275
Snippet from the message:
“Unless you are notified by your provider, please do not assume that clinic visits or clinical trial visits are cancelled. Both of these are considered medically necessary; contact your provider for questions or concerns.”
-vg_future
Wrong! There are many biotech companies that jump with results and hold their value and some even get bought pre-revenue. So, market does value pre-revenue companies.
-vg_future
BIIB's context, money power, need are different...rather more desperate. Anavex's approach has always been, move forward only if it worked until the current point.
-vg_future
It is not mentioned, but it might most likely be hidden in the "undisclosed" indications. Anyway, my point was about their hedging approach...setting themselves for future. They don't want to be left alone when everyone else takes off.
-vg_future
Thanks for the additional info Doc328. Appreciate it. It felt like Biogen is hedging (good strategy for any company) for future if not for immediate need.
Anavex has gotten the street's attention now and is perfectly set for a great run once the results/indications starting coming out. Wish there was good response for the MS article. It will happen eventually.
JMHO,
vg_future
Yes, couldn't agree more. It is a bad combination of government agency's inefficiency and pharma companies' greedy/cunning tricks impacting the suffering people.
-vg_future
couple of tidbits from inference
1. Biogen’s so called FDA arm twisting might not be working as they hoped (so, either they might nit be able to re-run them or approval is proving to be harder)
2. Gene therapy and precision medicine is being embraced by all....luckily Anavex has a head start.
This deal decision might as well be because of Buffet.
JMHO,
vg_future
Speculation - BIIB's deal with Sangamo. Anavex might be close to a deal with a big pharma or an announcement of significant NEWS and BIIB might be just attempting to save their position in the market by preempting with their own deal with Sangamo.
I will await Anavex's NEWS.
-vg_future
Pcguy, I beg to differ. I don’t want to credit the upward movement to some rumor/leak. Anavex moved on its own merit. The downward could be an opportunistic manipulation or a combo of market and profit taking.
JMHO,
vg_future
Are you saying that our upward movement was due to the speculation or the downward pressure from the leak that it is someone else that BIIB is partnering with?
The upward movement is purely the stock strength....fast track, enrollment completion, expansion of AZ sites. It was a long overdue run and still not enough by the standards of the potential that the stock holds. The downward pressure could be due to many things....a leak being one of them.
JMHO,
vg_future
Biogen and Sangamo agreement gives a glimpse of an equity stake agreement. Biogen might end up making more money than the upfront money just on the equity stake....a win win situation.
-vg_future
Agreed. For his investment levels, he can get in at any point and still make his money since his strategy looks for a home run...it is more about consistency. I was only saying that he doesn't have to buy Biogen to get to Anavex, but he can always influence their strategies which could involve buying/partnering with Anavex.
-vg_future
Buffet also invests in companies that have value (in parts) and not run properly. He becomes active investor and helps them turn around either by changing things or divesting useless parts. So, not sure where Biogen would fit though. Also, if he wants to invest in Anavex, he can do directly...doesn't have to come through Biogen and pay for the extra layer of Biogen. So, I don't but the theory of Buffet-Biogen-Anavex. Having said that Biogen or any other bio pharma could make a play for Anavex (and most likely will do so considering Anavex's potential) irrespective Buffet or any other active investment groups.
JMHO,
vg_future
Okay. Thanks for clarifying and highlighting “clinical data” part that Missling stated. As sage4 said, it might not be The article, but still it is good to see good coverage through another peer reviewed article.
-vg_future
Sage4, thanks for digging it up. Much appreciated.
vg_future
Thanks TTTav66. Is this the peer-reviewed article? TIA.
I know folks (or maybe someone in Anavex's IR said that) think that we might not need it since all the advantages of Anavex's approach are well known/published now, but it doesn't hurt to have an additional confirmation.
-vg_future
Agreed. Next quarterly report would reveal the amount raised (if raised) and the change in the shares....we can only deduce the average price. Anyway, not that important as long as the share price keeps going up and the company is delivering.
-vg_future
Raja48185, as I mentioned in my other post to ExtremelyBullishZig, I am not against company raising money and it will be a show of confidence for the upcoming activities lined up for this year. But, I think they would rather raise over 100 million (needed for the pipeline) with the right kind of NEWS.
vg_future
I am not saying that they wouldn’t/shouldn’t be raising cash....particularly with some much activity needed this year. I am saying that they might wait for little bit longer ($6 a pop is better than the $3 from a few weeks back or from tha last time they raised the money) and raise cash in a big way or handle it with partnership once the NEWS is let out of the bag (of course I am assuming they are privy to the NEWS and like what they are seeing so far in the trials)..
JMHO,
vg_future
I think they would wait for some announcements and/or results to be published (March, 2020?) before raising money because the price trend is pointing higher. They could potentially partner with someone and eliminate the need for raising capital at these prices.
JMHO,
vg_future
Anybody know if Tom Bishop has updated/published a report after the recent Anavex CC? He is rooting for AVXL and had some intriguing questions on the CC.
TIA
vg_future
Plexrec, thanks. Is this from the report after the recent CC? Has Tom published an updated report...would love to see it. His questions about the expansion of sites and urgency was good, so wondering if he has formulated a theory or has some analysis. TIA.
vg_future
Thanks pcguy. Some analyst targets are too old and way off. Most likely their targets have been updated since 2018 (the ones that are saying $7 and $8). The other target of $54 - would love to see that report.
vg_future
I like this better. When we are guessing/hoping...why not the pop! Hope we wake up for a great surprise from Anavex one of these days.
vg_future
then you should be careful about them as well.
I stand corrected. Slides are saying "irreversible". Basically , the current status of the disease. Hoping to see "reversible" in future.
-vg_future
Here we go again....no good thing with Anavex can be good. We keep over analyzing until we can sleep tonight knowing that we brought down an expert to our level. Why can’t it be reversible....isn’t that a great thing! Do we really hope for a cure or just desperate to rule out any positive break through.
I would leave it to an expert and person in the know like Missling until this science unravels rather than second guessing his words and statements.
-vg_future
Reposting - could this be due to PA?
This caught my attention from the CC
Tom Bishop
But is there some reason for the acceleration? I must admit to having had some exciting anecdotal news of patient improvements coming out of Australia. And that we’re just…
Christopher Missling
So we are excited about this program. And we already had said previously that the Phase 2a Alzheimer’s study gave us the confidence to move forward into this Phase 2b/3 study, and that is the basis of now accelerating this because we are realizing that we want to now make sure that the study is finishing sooner than later. And so we were confident so far with the first 50%. And now we are moving to this level of acceleration by increasing the number of sites.
This sounds like someone or some agency might be pushing them for completion. Would a PA fit that urgency with a given a timeline to prove. I think so. Great and exciting times ahead.
JMHO,
vg_future
There are many exciting things in the CC, but this caught my attention
Tom Bishop
But is there some reason for the acceleration? I must admit to having had some exciting anecdotal news of patient improvements coming out of Australia. And that we’re just…
Christopher Missling
So we are excited about this program. And we already had said previously that the Phase 2a Alzheimer’s study gave us the confidence to move forward into this Phase 2b/3 study, and that is the basis of now accelerating this because we are realizing that we want to now make sure that the study is finishing sooner than later. And so we were confident so far with the first 50%. And now we are moving to this level of acceleration by increasing the number of sites.
This sounds like someone or some agency might be pushing them for completion. Would a PA fit that urgency with a given a timeline to prove. I think so. Great and exciting times ahead.
JMHO,
vg_future
XenaLives, high probability that PA has already been applied for and is in review considering the amount of data (showing positive results) available down under.
JMHO,
vg_future
And the restlessness and desperation continues and grows. I am more confident now that we are closer to success. Awaiting updates in coming days/weeks.
vg_future
Nice try. The fear of Anavex’s success is creeping in. Fun to watch.
-vg_future
Tradeherpete, agreed. The time seems to be ripe for a perfect announcement for the long awaiting patients and families.
-vg_future
Tradeherpete, excellent point. Maybe something is about to be made public and hence the permission to speak freely (and still not reveal completely and violate rules/regulations of the trials).
Also, now I see the value in how Anavex is guarding the NEWS(even though I would have loved more updates for the sake of long term holders/believers) - that is an excellent way to counter the subtle and distracting negative campaign that is going on with Anavex.
JMHO,
vg_future
Regions vs International expansion. Hope I am not stirring up another discussion about regions in Australia vs international sites. Based on the article that TTT has posted, Stephen Macfarlane seems to be saying that the expansion will/could happen at a global level....meaning Europe and NorthAmerica and not just other regions within Australia. So, what Missling meant about regions could be international expansion because they have seen historic (or maybe even maxed out) enrollment in Australia.
JMHO,
vg_future