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ONTX reverse-merges with—(private)—Trawsfynydd Therapeutics:
https://www.globenewswire.com/news-release/2024/04/02/2855799/0/en/Onconova-Therapeutics-Inc-and-Trawsfynydd-Therapeutics-Inc-Announce-Business-Combination-to-Form-Traws-Pharma-Inc-a-Best-in-Class-Virology-and-Oncology-Company.html
$VKTX bouncing off 73's anyone liking it here or wait?
XLO 1.38 - nice buy. I exited my last shares yesterday before close and will attempt to swing trade the momentum, shortterm. Longterm, I thought the recent news was pretty dynamic for a $1 biotech stock and may try to build a poke to just hang on?
Recent Biotech Bankruptcies/Liquidations/Dissolutions
[Added ACOR and EIGR.]
*Emerged from bankruptcy as FCSC.
iHub
Company Date Reference
ACOR 4/24 #msg-174156166
ADLS 5/11 #msg-62813901
AFFY 6/14 #msg-103663749
AGIX 1/09 #msg-35019458
AKAO 4/19 #msg-148227772
ALNA 9/22 #msg-169875553
ALPIX.PA 11/23 #msg-173275218
ALTU 11/09 #msg-43509933
AMB.TO 8/09 #msg-40145970
AMPE 4/24 #msg-174111257
ANSV 1/10 #msg-45161615
ARAV 1/24 #msg-173646720
ARDM 2/19 #msg-146903332
ARLZ 8/18 #msg-142824112
ARNI 12/17 #msg-137120846
ARTE 12/08 #msg-33895436
ASP.TO 1/23 #msg-171046860
ATHX 1/24 #msg-173589749
ATNX 5/23 #msg-171913749
AXLA 12/23 #msg-173374718
BAXS 11/14 #msg-108147336
BCART.BR 9/23 #msg-172903024
BIND 5/16 #msg-122328088
BIOA 5/18 #msg-140549553
Biolex 7/12 #msg-77324773
BPUR 7/09 #msg-39629524
BTTX 3/24 #msg-174037486
BVTI‡ 3/13 #msg-85440257
CALA 1/23 #msg-170898055
CBIO 6/22 #msg-169273606
CDAK 3/23 #msg-171544942
CJB.TO 7/10 #msg-52557510
CHKT 12/08 #msg-33949508
CLSC 8/09 #msg-40685152
CLVS 12/22 #msg-170599077
CRXT 9/22 #msg-170229149
CWBR 11/23 #msg-173138450
DCGN 11/09 #msg-43629379
DDXS 6/16 #msg-123229557
DMK 2/24 #msg-173773814
DNDN 11/14 #msg-108004147
DXTR 12/17 #msg-136829445
Egenix 1/15 #msg-109921347
EIGR 4/24 #msg-174151841
ENDP 8/22 #msg-169707980
Epix† 7/09 #msg-39900524
EPRS 7/16 #msg-123687350
EYES 6/20 #msg-156388471
FRTX 9/23 #msg-172854853
GMDA 3/24 #msg-174125313
GNCA 5/22 #msg-168957883
GNTA 8/12 #msg-78123007
GTOP 9/08 #msg-32249160
HEMA 4/12 #msg-74167597
HGEN 7/23 #msg-172432338
HSTO 9/23 #msg-172847239
ILIU 7/17 #msg-133264435
IMMG 8/17 #msg-134305213
IMNP 2/19 #msg-146936897
IMV 5/23 #msg-171814610
INFI 10/23 #msg-172941539
Inspiration 10/12 #msg-81024196
INSY 6/19 #msg-149302493
Introgen†† 12/08 #msg-33947783
Isolagen* 6/09 #msg-38746197
KBIO 12/15 #msg-119489701
KLDO 4/22 #msg-168491485
KV.A 8/12 #msg-78203130
LBPS 6/22 #msg-169255625
LHDX 2/22 #msg-171275021
LIAN 2/24 #msg-173835088
LMDX 12/23 #msg-173530663
MACK 2/24 #msg-173845049
MBRK 4/10 #msg-49658072
MBVX 3/19 #msg-151985211
MIIS 11/08 #msg-33720220
MIPI 12/10 #msg-57646943
MLNT 12/19 #msg-153074747
MNK 10/20 #msg-158843178
MRV.TO 3/23 PR link
NBSE 3/24 #msg-174119874
NEXI 11/23 #msg-173152495
NMTI 4/11 #msg-62251315
NMTR 7/23 SEC link
NOVN 7/23 #msg-172361873
NRGX 3/12 #msg-73415156
NRX 5/16 #msg-122331475
NSTG 2/24 #msg-173773766
NVDL 2/17 #msg-128923029
NVIV 2/24 #msg-173755991
NVLN 1/20 #msg-153111867
NVTA 2/24 #msg-173844970
OBSN.SW 2/24 #msg-173937364
ODT 3/21 #msg-162706983
ONCR 6/23 #msg-172037432
ONCS 6/23 #msg-172145325
OREX 3/18 #msg-139213097
ORPH 3/22 #msg-168169591
OSCI 7/09 #msg-39511719
OTIC 12/22 #msg-170737355
PEAR 4/23 #msg-171639648
PHAS 10/22 #msg-170272758
PLXP 4/23 #msg-171677346
PROMO.ST 10/23 #msg-173007859
PTX 2/19 #msg-146937356
PYMX 4/13 #msg-86313192
PZRX 12/17 #msg-136794351
QTNT 12/22 #msg-170676963
RCPI 8/16 #msg-127560117
REX 11/08 #msg-32189097
ROKA 8/17 #msg-133945967
ROSG 6/18 #msg-141797330
RUBY 2/22 #msg-171270235
RVALL 1/20 #msg-153358221
RVLP 10/23 #msg-173007859
RXPC 7/14 #msg-104103329
SCLX 2/23 #msg-171193757
SGYP 12/18 #msg-145394802
SIEN 2/24 #msg-173834941
SIGA 9/14 #msg-106313111
SIOX 12/22 #msg-170699458
SNNA 9/19 #msg-151196707
SPHS 5/20 #msg-155712447
SRGA 6/23 #msg-172201878
SRNE 2/23 #msg-171193757
SVNT 10/13 #msg-92997648
TDLP 6/11 #msg-64744114
TLCV 12/09 #msg-44751578
TMBR 11/23 #msg-173254229
TOMDF 12/23 #msg-173490278
TPPH 2/08 #msg-26765260
VION 12/09 #msg-44654555
VLRX 2/20 #msg-153741993
VRA 10/07 #msg-18053275
VRAY 7/23 #msg-172361873
VVUS 7/20 #msg-156752080
ZSAN 6/22 #msg-169035970
ACOR files for bankruptcy—drug portfolio bought by Merz (subject to approval by the bankruptcy court):
https://www.businesswire.com/news/home/20240401939079/en
GUTS—I’ll be astonished if this device works as advertised:
https://www.globenewswire.com/news-release/2024/04/01/2855050/0/en/Fractyl-Health-Receives-FDA-IDE-Approval-for-the-Revita-Remain-1-Pivotal-Study-of-Weight-Maintenance-in-Obesity-after-Discontinuation-of-GLP-1-Based-Drugs.html
Yes, Sorrento / Henry Ji was notorious through $SRNE existence for pumping one drug after another to make sure management continues to "earn" a salary while bleeding naive investors dry. This happened especially during Covid-19. I think he said something like "short sellers and their family will be real sorry" (super paraphasing because I can't remember the exact phrase).
So his mere association with Aardvark will give me serious pause, not that I care about IPOs in general.
I also didn't realize this is a thing: https://www.reddit.com/r/BANDOFBROTHERSOFSRNE/comments/1ba0mib/congratulations_henry_ji_you_messed_over_everyone/
GRTS—(-40%/AH)—reports purportedly-positive phase-2_data_for colorectal-cancer vaccine:
https://www.globenewswire.com/news-release/2024/04/01/2855416/0/en/Gritstone-bio-Announces-Positive-Preliminary-Progression-free-Survival-and-Long-term-Circulating-Tumor-DNA-ctDNA-Data-from-Phase-2-Portion-of-Ongoing-Phase-2-3-Study-of-its-Persona.html
I was able to get XLO at $1.16 this morning. Not sure why it took so long to gap up, but I'll take it.
Bladerunner
If the only thing I knew about RVNC was that they had the most superior Botulinum toxin on the market for years ahead, would that automatically confer/ bestow immediate stock value translated into, now at its current stock price and current management , is the compelling time to buy RVNC? And what argument would I use to duel with distractors who contend RVNC must dilute , to boost their financial' s by adjusting stock price lower with the value of those shares sold allowing them to remain solvent, insuring inflicting near term pain for current stock holders?
FDA clears ABT’s 15-minute test for TBI/concussion:
https://finance.yahoo.com/news/abbott-receives-fda-clearance-whole-130000849.html
Note: This is not the hand-held diagnostic ABT is developing to give TBI results from a simple finger prick (#msg-172397644).
You could well be right. We'll know more when they go public.
The folks and dealings associated with Aardvark's history just seem a little sus to me, although maybe there's really nothing there to be concerned about. I can understand there's a lot of back scratching that goes on in business in general, but... it just peaked my interest when i noticed the association with Sorrento's Henry Ji who's a bit of a controversial character in biotech especially during Covid-era and served on Aardvark's board of directors following the transaction Sorrento struck with Aardvark (https://investors.sorrentotherapeutics.com/news-releases/news-release-details/sorrento-therapeutics-and-scilex-holding-majority-owned) Also Vickers being one of Aardvark's Series A investors, Vickers involvement with $SCLX which was majority owned by Sorrento and brought public via Vickers Vantage spac. I can only assume Ji and Aardvark's founder/CEO Tien Lee met while Lee was at NantKwest (most of Aardvark's leadership team came from $NK now $IBRX). Remember that Scilex was majority owned by Sorrento prior to their coming public in 2022, and Tien Lee Aardvark's CEO joined Scilex bod in late Feb '19. This was 2 years ahead of ARD-301 licensing by Sorrento/Scilex... and then there's the whole Sorrento bk. There's just so much incestuous stuff going on here, and yet, maybe it says nothing about the legitimacy of Aardvark. IDK.
associated with both AVTX and IBIO on the same day. 🤷 good for him.
You underestimated my laziness!! 😂
Well my ploy was to get you to verify it .
So obviously I've failed in that endeavor :--)
Kiwi
Kaiser is a very busy guy, but he is very interested in DR and thinks $OCUL has the potential to make it practically treatable.
ij
The simple answer is that Dr. Kaiser was working for OCUL less than 50% of the time. Rather than be in violation of an employment covenant, he renegotiated the contract.
I wonder what the full explanation of “to eliminate his 50% service requirement” entails? As it doesn’t imply otherwise, I assume he still holds the position without the service “requirement”.
AI - FWIW
I have been using several AI engines. Sometimes I ask the same question of each.
Claude3 and Gemini are the worst for my queries. Claude frequently comments it is not current and thus cannot inform beyond August '23. Gemini likes to make you refine your query and then tells you all the reasons it cannot answer.
Perplexity and Pi are my favorites in that order, but it is close. ChatGPT (CoPilot uses it) is good but so far not as good as Perplexity and Pi.
I have read that MSFT CoPilot will be processing some of the requests locally and taking some of the processing off the cloud to speed things up. They are going to require computers to not only have the normal CPU's and GPU's but also a NPU capable of operating at over 40 TOS.
The time saving in getting basic information together is enormous. As others have pointed out, we cannot trust the answers blindly. I have noted some. But these tools are just getting started. For those of us who are not geniuses or topic experts, the tools are good today and in a couple of years we won't be able to spot errors if there are any.
How do you know if Chat GPT didn't summarize the key pts accurately ...unless you actually looked up the FDA doc. ?
You can't .
The value of this board , to me at least , is that generally posters will back up their pts of view with links supporting their opinion.
Kiwi
Re: XLO
This is a penny stock, isn't it.?
Bladerunner
Right.
There are ways to use AI to speed the search but you still need to check the results, they even spew out false references sometimes.
Of course, there are ways to search the text of a specific webpage or .pdf and some of those are via AI. That makes it faster to find specific text or to locate keywords. Old technology that predates AI can be pretty efficient.
I've overspent my daily 5 minutes on this site today. Later.
Exactly
Except it’s time consuming. If you can get references for the answers from searches that would be an improvement bc then you can judge the trustworthiness of the sources
We all know there is misinformation out there and my understanding is that current generation of AI can’t always distinguish good from bad sources. Chatgpt could be correct here but If it’s garbage in then it’s garbage out
So how about getting the correct answer ...copy and pasting it for us so we can see how accurate ChatGPT was ...and the time it took you to find the answer.
I'm not saying ChatGPT is perfect ...its obviously a work in process ...and I'm biased as NVDA has been my 1/3rd largest position for the past 10 mths
Kiwi
Well the question was ...Market exclusivity following approval .
Where is that mentioned in your links ( copy and paste section ...thx ) and how much time did you spend finding it ?
Kiwi
Why even ask ChatGPT when you can go to source material?
FDA Breakthrough Devices Program
https://www.fda.gov/medical-devices/how-study-and-market-your-device/breakthrough-devices-program
Guidance PDF
https://www.fda.gov/media/162413/download
PHARMACEUTICAL TECHNOLOGY research news via GlobalData -
March 29, 2024
Enanta Pharmaceuticals gets grant for inhibiting coronavirus replication with compound of formula (i)
Enanta Pharmaceuticals has been granted a patent for compounds that inhibit coronavirus replication. The patent covers pharmaceutical compositions and methods for treating or preventing coronavirus infections. Claim 1 specifically pertains to a compound represented by Formula (I).
Excerpts:
Additionally, the patent includes claims for pharmaceutical compositions comprising the disclosed compound and methods for treating or preventing virus infections, specifically coronavirus infections such as those caused by 229E, NL63, OC43, HKU1, SARS-CoV, or MERS coronavirus.
The patent's claims highlight the compound's versatility in treating various virus infections and respiratory disorders, positioning it as a valuable asset in the field of antiviral and respiratory therapeutics.
Read more:
https://www.pharmaceutical-technology.com/data-insights/enanta-pharmaceuticals-gets-grant-for-inhibiting-coronavirus-replication-with-compound-of-formula-i/
Some more :---)
Thanks—good to know!
ChatGPT's answer
An FDA breakthrough designation does not entitle the manufacturer to a period of marketing exclusivity, as far as I know. Maybe you are thinking of an FDA Orphan Drug designation, which confers 7 years of marketing exclusivity.
Yes ...Breakthrough designation if approved grants market exclusivity for ??? years ?
Kiwi
Thanks. The word, "circuit" refers to the dialysis loop, right?
TEVA sues AMRN for_alleged cornering of Vascepa API:
https://www.fiercepharma.com/pharma/teva-follows-suit-after-hikmas-2023-complaint-arguing-amarin-locked-drug-ingredient-supply
Dew. a more specific answer to your questions re TLPH
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