zip, I totally agree with you. Just an additional point in support of your perspective: Dr.Berger does not make dosage decisions by barking orders at his underlings who carry out his orders unquestioningly. In fact it's a decision that was made with the best understanding of risk/benefit at the time, with the full participation of not only Ariad's senior staff, but the very best experts out in the CML community.
In fact, the 45 mg dose may be the correct dose - at least to start treatment.
You are only able to make that statement now, AFTER the EPIC stoppage. I happen to agree that there are patients who need to begin therapy on 45mg but there simply is no justification to conduct a front line trial with the highest dose available when the drug was not fully understood to begin with....especially when patients would be expected to stay on drug for 10 plus years.
I would bet my bottom dollar that there was extensive conversation and disagreement on dosing for EPIC 45mg v 30mg. We may never know that but in the end what we do know is that it was entirely HB's decision as CEO.
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