Replies to post #3102 on NorthWest Biotherapeutics Inc (NWBO)

[ou71764]

gpb,

Good points. I agree completely.

The immune system has clearly failed at the time the time the patient has surgery. But after surgery and the initial chemo, the cancer is at its ebb and the chemo hasn't poisoned the patient yet. It's the optimum time for the vaccine to succeed.

The patient's dendritic cells are being prepped for the vaccine outside the patient. Whatever deception the cancer has imparted to the dendritic cells that are left in the patient, the cells growing outside the patient that will be used for the vaccine aren't subject to that.

[flipper44]

gpb, logical reasoning in your theory why DCVAX-l efficacy benefits more from major resection than chemo.


In your collateral inquiry regarding dosing and timing, In one of Linda Liau's reviews, she noted that booster shot timing and dosage is sometimes counterintuitive; in that, sometimes too much booster too early can cause inefficacy….she sated it had something to do with programmed cell death interference (over my head at the time). In some cases, after initial DCVAX-l therapy, it appeared that booster shots with tumor lysate alone worked quite well.