JL%jtf3: There's significant evidence that HDL is no longer the accurate metric it used to be. PFE and MRK both dropped the HDL mimetic programs. PFE's PH III HDL mimetic missed both primary and secondary endpoints. At a UBS conference MRK commenting on discontinuing their HDL mimetic program, stated the concept of good cholesterol has lost support among Cardiologists. I happen to agree and have for many years.