Replies to post #4956 on Amarin Corp Plc (AMRN)

[drrc1949]

Maybe there's a deep pockets issue here as well AK and the Docs you're hanging out with aren't paying attention to it. There is no getting around the fact that, with the Vascepa discount program, the first year costs are way less than the costs for comparable DS treatment. I hope your friends look at you and think, "Heck, he can afford it or don't bother thinking about the finances at all". Unfortunately, you and I know everybody's not in that boat.

[Chabojilo]

Lowering LDL-C was a non-factor in the JELIS study. In both arms, LDL-C was reduced the same amount. However, there was a 19% reduction of MACE in the EPA+statin arm.

Dr. Sears, J.L's mentor of sorts, attributes this to Arachidonic Acid reduction, as you can see in the results of JELIS.

AA/EPA was reduced in the EPA+stain arm compared to statin alone. Statin increases the production of AA and EPA works synergistically to inhibit the enzyme that produces AA, delta-5-desaturase. Trigs/HDL was also reduced in the EPA arm compared to statin arm. So both of these markers are more of an indicator than LDL-C in this population.

Tell your Doc about statins and Arachidonic Acid and EPA's inhibition of delta-5-desaturase to slow down AA production.