Replies to post #84385 on Avid Bioservices Inc (CDMO)

[freethemice]

Entdoc, I think too much is made of this. Rituximab is a chimeric mAb that was approved 15 years ago
and is still going strong. It gained approval two years ago for maintenance therapy for follicular lymphoma.
http://en.wikipedia.org/wiki/Rituximab
I think if bavi + docetaxel is actually working to stop metastasis, as it seems to be doing in second-line NSCLC,
it is working against small tumors already. I think what is going on is that the primary tumors are stable and
the treatment is preventing the small tumors which start in other organs from growing into larger tumors.

[volgoat]

I would imagine Humanized would be better for long term administration, less rash and irritation...
They must like the chances of giving Bavi over and over.....

Humanised antibodies are produced by grafting murine hypervariable[disambiguation needed] amino acid domains into human antibodies. This results in a molecule of approximately 95% human origin. However it has been shown in several studies that humanised antibodies bind antigen much more weakly than the parent murine monoclonal antibody, with reported decreases in affinity of up to several hundredfold.
http://en.wikipedia.org/wiki/Monoclonal_antibody_therapy#Chimeric_and_humanized_monoclonal_antibodies_.28suffixes_-ximab.2C_-zumab_respectively.29