My simulations took into account the timing of enrollees. As I indicated in the previous post, the trial will achieve stat sig about 50% of the time if the trigger was 240 and D9901+02a assumed as the model. But you also need to think through issues about the health of early patients and also of late patients as deviations from D9901+02a. Early simulations seem to indicate that the chance would be better, not worse.
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