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Re: ocyanblue post# 5611

Friday, 04/11/2008 12:47:30 AM

Friday, April 11, 2008 12:47:30 AM

Post# of 12660
Thanks Ocyan - I was just looking to see if you concur that if 9902b achieves a HR of roughly 1.3 at the final, as postulated by P3analyze on IV, it should be a success? A 1.3 HR ain't bad. I worry because with roughly 60% patients at the interim, and 40% at the final with less than 24 months from randomization - this group could really hurt overall HR with maybe an HR of 1.1 based on looking at 9901/9902a. This leaves the remaining 40% or 60% later enrolled patients to carry the day - and they would need an HR roughly over 1.7 (and that is 0.2 higher than the integrated) to bring the study to roughly the 1.4 level, if that's enough to meet p-value requirements? Do the later enrollees worry you? Thanks

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