Replies to post #680861 on NorthWest Biotherapeutics Inc (NWBO)

[skitahoe]

Doc, I don't believe that pseudoprogression was an issue with those on the SOC, I believe it was purely for those who got the vaccine who were thought to being progressing, but who actually were getting better, IE pseudoprogressing. Those on the SOC who never crossed over were simply too sick or passed on before they had the opportunity.

This scenario creates K-M curves which show patients on the vaccine progressing before those on the SOC do, but it's because their pseudoprogression was called progression and that call was never reversed, even though the patient continued to improve, and may in fact be living today. It's rather like a totally incorrect call in a sport activity, once the call is made it becomes official no matter how wrong it is.

I'm frankly uncertain today if a new trial were established whether progression would be a legitimate goal because they now have an acceptable way of differentiating between progression and pseudoprogression during the trial. I don't know if some sort of intrusive activity, like multiple needle biopsies of the tumor, would be considered acceptable for differentiating between progression and pseudoprogression. If some sort of scan cannot make this determination, I believe the only goal may be overall survival, which is the gold standard, but clearly takes longer, and costs more.

By the way, by my count we're at T-59 for UK approval.

Gary

[Nemesis18]

Sir,
Thankyou for your very informative response, for it has guided me as to the next steps that I must take.

Interestingly, after being given just two weeks to live over the telephone by the Clinical Trial Patient Procurement Nurse, upon discharge from Kings College Hospital in March 2015, after being successfully treated for a tiny brain abscess, derived from a tooth infection, I was referred to their arranged surrogate Oncologist.
Who stated that fortunately, he had one place for me left on the very latest NICE Gold Standard Treatment, and that I should consider myself lucky.
As an Inspector, It was in my nature to drill down on the presented ‘facts’. One being that there was never any scanned evidence to show the existence of a brain tumour. ( then or now)
I remained reluctant to proceed with the STUPP protocol. But I relented, as his anger at my refusal wore me down, so soon after surgery.
He refused my request for a scan before the start
Of adjuvant treatment,

A scan was further refused once again by the oncol.at the end of 6 weeks chemo/ radio,
I knew then that there was an agenda at play, that was not necessarily in my best interests.
I then demanded a scan at 6 weeks, as a precondition of me having a follow on temozolomide course.
I finally got a scan, that had previously been refused because ‘pseudo progression’ would have enflamed the multiple tumours’- end quote.

My long overdue demanded scan showed no evidence of GBM4 ( giant cell variant), so I sacked the Oncologist on that very day, ditched all prescribed medication. 9 years ago.
So as a former 2015 ‘gbm4 patient’, I have the absolute right to enquire, and to glean any pertinent info from where I see fit.

I never was I’m any danger of dying back then, despite Kings College Hospital’s attempt to convince me otherwise. And after 3 years of attempted intervention into my life, they finally conceded defeat, by leaving me alone for good.

No I return to get some answers from them.

And for those here that ‘has a friend at Kings’, I caution you that the MHRA’s Investigation Team are looking into that and other broad ranging matters.
And they have been for the last 6 months.

Also to those who suggest that I maybe in legal jeopardy here, for, in their mind, ‘fudding’ NWBO, you are very much Regulator’ly out-gunned in that regard. So put your water pistols away!

And I know that NWBO investors here will really applaud me being open about my Kings College Hospital GBM4 story, because you really ‘care’ about curing this brain cancer, and with it having absolutely nothing to do with getting your sweaty grubby hands on a few dollars !

Do let me know if you want the CHM’s Chairman’sor the MHRA’s CEO’s direct emails !

.. discuss