Replies to post #677290 on NorthWest Biotherapeutics Inc (NWBO)

[exwannabe]

Historically vaccines have been solely prophylactic (preventative) agents as a way of preventing infectious diseases. One of the first was introduced by Edward Jenner who treated people with infectious material from patients with the mild infection of cowpox (variola vaccinae - Latin for "smallpox of the cow") to prevent the potentially fatal human Smallpox (variola). He named the process Vaccination (for obvious reasons). With the DCVax family we now have the first examples of established disease being treated by vaccination (incorrectly named from my point of view).

Did you forget that the first Dendritic Cell vaccine was approved over a decade ago?

There is also BCG used to treat bladder cancer.

But if we are talking imuno-oncology we have a bunch more.

[georgebailey]

Doc Lee wow thanks for that- question for you- this recent case where only half the tumor removed and the remaining half shrinking to almost nothing is so incredibly impressive……my question is can you make a good guess as to how DCVax was improved and
modified to achieve this result? For this patient’s case to get published means this is very very special.

[Chiugray]

DocLee, Thanks for that insight and information about vaccines and potential of DCVax there.

My hypothesis was modest, thinking only of the overlaps of cancer epitopes. That it creates a prophylactic effect against a potential second primary cancer, and that would be an important by-product or benefit to cancer patients that use DCVax to treat their initial primary cancer, that may be overlooked today. But I think you are saying there is a potential market opportunity here as well.

With Dr Bosch's observation that there is a considerable overlap of malignant epitopes between various unrelated malignancies, a potential new realm of prophylaxis (ie "true" vaccination) opens up. This would be the prevention (by vaccination) of many/most/all malignant diseases using a simple extension of the the DCVax method which for the mid-term future would be the only way of achieving this end.

Let me emphasize that point: a vaccination against cancers. I think that is major. Thanks again. I think over time, more opportunities we have never thought of before will emerge with this versatile DCVax technology platform.

Sorry if I repeat this too often, but NWBO is a UNICORN COMPANY and by definition will disrupt existing markets and open up a greenfield of new undiscovered ones.

[ccie1024]

“A therapeutic vaccine is one in which the vaccine is used after infection occurs, aiming to induce antiviral immunity to alter the course of disease.”

“The greatest strides in therapeutic vaccine research have been in the treatment of cancer.”

Of the three vaccines approved for use in the United States, two are used to treat advanced cancer that has spread to distant parts of the body (metastatic disease), while the other is used to prevent the progression of carcinoma in situ (a precancer condition).

The approved vaccines, from oldest to newest, are:

Tice (Bacillus Calmette-Guerin): A live-attenuated vaccine approved in 1990 for the treatment of carcinoma in situ of the bladder7

Provenge (sipuleucel-T): A dendritic cell-based vaccine approved in 2010 that is used for the treatment of metastatic, hormone-resistant prostate cancer8

Imlygic (talimogene laherparepvec): A live-attenuated vaccine approved in 2015 that is indicated for the treatment of advanced oncolytic melanoma (a type of skin cancer)9


https://www.verywellhealth.com/what-is-a-therapeutic-vaccine-3133276