Replies to post #2884 on Enanta Pharmaceuticals Inc (ENTA)

[DewDiligence]

[THRD] had 2 cases of DILI (drug induced liver injury) in their first 3 patients! They think they have identified the metabolite causing this and are hopeful.

Ouch!

I'm getting more excited about this area for ENTA if they can get a good compound. Liver tox is tough to predict preclinically (THLD acknowledged this), so the phase 1 next year is going to be quite meaningful (especially with a good biomarker of activity to go along w safety).

If I were a baseball manager, I would say ENTA was overdue for a successful at-bat, LOL.

[vinmantoo]

I'm getting more excited about this area for ENTA if they can get a good compound. Liver tox is tough to predict preclinically (THLD acknowledged this), so the phase 1 next year is going to be quite meaningful (especially with a good biomarker of activity to go along w safety)

dewophile, thanks so much for that detailed analysis. I must admit I haven't done any real digging into Kit inhibitors. I expect a real roller coaster ride for ENTA as their Kit inhibitor enters and proceeds through trials.