Replies to post #672892 on NorthWest Biotherapeutics Inc (NWBO)

[exwannabe]

Most chemo/rad psPD patients were screened from entering the main arm of the trial. Therefore, there were likely very few, if any, psPD from chemo/rad patients in either the treatment or control arms of the trial.

How is that?

The baseline MRI that screens out early progressions (and psPD) is 2 weeks after completion of RT+C.

Though numbers vary, papers generally say psPD presents weeks to months after RT+C. See https://radiopaedia.org/articles/tumour-pseudoprogression-brain-tumors

Also, the RANO criterion (not used to save time and money per LG) excludes images in the radiation zone for 12 weeks following RT+C as it is likely psPD.