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learningcurve2020

12/06/23 10:18 AM

#653668 RE: iclight #653665

Really Happy, that's not a very honest take on it.
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dstock07734

12/06/23 10:58 AM

#653682 RE: iclight #653665

Now you start trusting scientist. In this case, the scientist is Georgina Long who is an expert on melanoma. Did you hear that she was very excited about the increase of immune cells by 10 folds? How many folds has DCVax-L made immune cells increase? By now, you should know simply mentioning increase in immune cells is not good enough. What types of immune cells have dramatic increase matter a lot.

You think she watched Dr. Liau's presentation? I am sure you did. In the following slide, Dr. Liau mentioned that the immune response was so intense that she had to bring the patient to surgery to remove the inflammation due to pseudoprogression. Do you know what is Tocilizumab? It is immunosuppressive for rheumatoid arthritis. Dr. Liau had to use this drug to suppress the intense immune response. If 70 folds increase in t cells as shown in the following figure didn't bring patient to surgery (if it did, they should report it in the JAMA paper as adverse event), can you imagine the increase magnitude for this patient #5?

Read it again what Dr. Ralph Steinman, a Noble Prize winner dreamed of. Everyone having commonsense would agree what Dr. Liau achieved is beyond what Dr. Steinman loved to see.

BTW, for anyone who is long on using monoclonal antibody drug to treat cancer. If you are long also in NWBO, be careful about your investment in monoclonal antibody. As it can be seen, monoclonal antibody Bevacizumab (Avastin) can suppress immune response from DCVax-L a lot.