ATLn, I’ll chime in with $.02 starting with old post where the highlighted section may align with your thinking.
Agree likely some “art” involved in administering Direct injections to attain/ensure efficacy. Also on the direct patent the prosecution was lengthy. The time and changes made some think the claims were diminished. I think the attained what they needed (ex an I made this points at the time)
Coming in for landing try add more when time permits
We saw Owain James only had half his tumor removed and he only had three doses of DCVax-L. His tumor has been shrinking even four months after the last shot. I was wondering if this would lower the importance of pushing DCVax-Direct. If doctor can inject the Direct into tumor, certainly a certain amount of tumor tissue can be extracted to make DCVax-L.