Replies to post #600425 on NorthWest Biotherapeutics Inc (NWBO)

[flipper44]

It’s a lock and key system. T-cells are incredibly diverse individuals (due to evolution) in what antigens they can be triggered for. When a Dendritic Cell initially expresses to t-cells, most t-cells will move on until the right t-cell locks in to the right antigen on a DC expressing many antigens. (This happens in the lymph nodes). Once the right t-cell locks up with with dendritic cell’s antigen, the dendritic cell then transfers co-stimulatory molecules and cytokine stimulation to tell the t-cell how much to multiply and how aggressive to be toward the target tumor cells.

[attilathehunt]

"how the MHC molecules make their choice between self and non-self."

Perhaps, those molecules have a sense of smell that we are unaware of?!?!

Or they practice telepathy.