Replies to post #600427 on NorthWest Biotherapeutics Inc (NWBO)

[ae kusterer]

flipper44:BRAVO for clarity and simplicity !

Member Level
Re: hankmanhub post# 600425

Sunday, June 11, 2023 12:14:29 PM

Post#
600427
of 600427
It’s a lock and key system. T-cells are incredibly diverse individuals (due to evolution) in what antigens they can be triggered for. When a Dendritic Cell initially expresses to t-cells, most t-cells will move on until the right t-cells lock in to the right antigen on a DC expressing many antigens. (This happens in the lymph nodes). Once the right t-cell locks up with with dendritic cells antigen, the dendritic cell then transfers co-stimulatory molecules and cytokine stimulation to tell the t-cell how much to multiply and how aggressive to be toward the target tumor cells.

[brooktrail1933]

That's a fine and well-understood mechanistic explanation. Doc and I were referring to the teleological explanation, which the other gentleman is apparently not interested in.

[hankmanhub]

Thank you Flipper, I appreciate the response, unfortunately none of what you wrote is responsive to my question: How does the MHC differentiate between self and non-self?

[mike00h]

hankmanhub, this is an example of science. Intelligent design is not an example of science.

[eagle8]

Wonderful explanation of the system flipper.
Thank you for sharing with us.

GLTU