Replies to post #600385 on NorthWest Biotherapeutics Inc (NWBO)

[hankmanhub]

Atl, thanks again for taking your time with this.
We are not getting the AI to answer the questions I want the answer to. There are two stages here in determining self. The fist step is apparently done by the MHC molecules. They SOMEHOW determine which proteins are self or non-self in order to present this as part of the complex to the rest of the immune system. The second step comes when the rest of the immune system now recognizes what to attack as non-self based on the presentation of the MHC Complex previously determined by those MHC molecules. The AI keeps responding about stage two, but what I am asking about is the stage one and how the MHC molecules make the determination as to which antigens are self in order to incorporate them into the MHC complex.

Perhaps we should drop the entire first sentence. Then modify the second sentence by changing "this process" to "which proteins are self or non-self in order to incorporate them, or not, into the MHC Complex for presentation to the rest of the immune system?" Then conclude with the request for citation as before.

I have not yet had a chance to read the cites the AI produced. Maybe there is some info there I can use to answer the question - but for me, this is slow slogging. It is usually a lot easier to read a post on iHub than it is to read a journal article.
Thanks ATL.

[Tom33777]

It's TURTLES-all the way down!

Actually, the human body is one fascinating piece of machinery. How all the different processes of blood clotting, tissue healing, reproduction, energy production, stem cells and cell differentiation, telomeres and this other thing about cancer antigen recognition; can't really convince myself that it evolved from nothing. And still can't imagine why we are here.

[ADVFN_doclee]

Once again the explanation given is what the immune system does to non-self epitopes but not how it recognizes "non-self" from "self". It confirms that the MHC class I and II molecules are intimately involved in the process by "helping the patient's immune system to know which are self (normal) cells and which are cancerous gene mutations and antigens that the immune system needs to eliminate or destroy"...... " This allows the immune system to recognise and eliminate cancer specifically whilst sparing normal self-cells".
Again, nothing is said about how the system recognizes self from non-self.