BR. I was unaware of KZR until U mentioned them . Looking into their data I found they were able to rapidly lower proteinuria levels and wean patients off steroids within 12 wks. . Its the weaning them off steroids that interested me . LN patients ( mostly young women ) hate steroids ( Prednisone in this case ) because they make them especially prone to mood swings , weight gains plus additional side effects . Lupkynis enables them to taper the dose ...but KZR-616 is the only LN drug that I'm aware off that enables them to drop steroids completely .
The reason this is important is that its one thing to find a drug ( or drug combinations ) that works ...its another thing to keep LN patients on them if they have trouble with the side effects .
Agree that KZR is high risk / speculative and could blow up if they find safety issues etc in P 2 results ...so its not a "bet the farm " situation .
The feed back my wife gets from the Nephrologists she works with re Lupkynis ...has a role in treating severe LN but is overpriced so expect payor resistance in covering ...ie PA ( prior approval ) hurdles ...need to fail existing therapies first . Thx for the note on RVNC
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