Aurinia Pharmaceuticals Inc (AUPH)

[Whalatane]

BR. I was unaware of KZR until U mentioned them . Looking into their data I found they were able to rapidly lower proteinuria levels and wean patients off steroids within 12 wks. .
Its the weaning them off steroids that interested me .
LN patients ( mostly young women ) hate steroids ( Prednisone in this case ) because they make them especially prone to mood swings , weight gains plus additional side effects .
Lupkynis enables them to taper the dose ...but KZR-616 is the only LN drug that I'm aware off that enables them to drop steroids completely .

The reason this is important is that its one thing to find a drug ( or drug combinations ) that works ...its another thing to keep LN patients on them if they have trouble with the side effects .

Agree that KZR is high risk / speculative and could blow up if they find safety issues etc in P 2 results ...so its not a "bet the farm " situation .

The feed back my wife gets from the Nephrologists she works with re Lupkynis ...has a role in treating severe LN but is overpriced so expect payor resistance in covering ...ie PA ( prior approval ) hurdles ...need to fail existing therapies first .
Thx for the note on RVNC

Kiwi