Replies to post #334054 on Anavex Life Sciences Corp (AVXL)

[raja48185]

Falconer,

May be you could share your thoughts in the comment section of that article.

[peeved]

Just because the sigma one agonism causes b amyloid production doesn’t mean that Alzheimer’s is going to be prevented with any activation as is exemplified by the lack of success in Beta amyloid drugs. furthermore it is entirely possible that Anavex 2-73 stimulates the receptor in such away in such away that it alters cell homeostasis without increasing amyloid production since a receptor can have more than one ligand.

Also mouse studies done by anavex never increased amyloid production In pre-clinical studies. This harvard study was also done on mice so that is comparable

[nidan7500]

falconer66a....YOU DA MAN...nicely done.

Of course, blarcamesine (Anavex 2-73) does activate the sigma-1 receptor protein. BUT, as numerous studies have shown, it does not prompt amyloid beta production; just the opposite. Blarcamesine's particular (unique) activation of the sigma-1 receptor causes it to subsequently facilitate and modulate a number of downstream processes in the neuron that, in fact, make it work normally. Alzheimer's symptoms are thereby suppressed or prevented --- as the human clinical results will show when the big double-blind clinical trial of blarcamesine against Alzheimer's will reveal, some time next year.

Go buy a round and celebrate a little. Send the bill to Dr. M..