Replies to post #331928 on Anavex Life Sciences Corp (AVXL)

[Bourbon_on_my_cornflakes]

Excellent research Sokol. Thanks!

#8 was especially interesting: Aging is a common risk factor for the occurrence and development of many diseases, such as Parkinson’s disease, Alzheimer’s disease, diabetes, hypertension, atherosclerosis and coronary heart disease, and cancer, among others, and is a key problem threatening the health and life expectancy of the elderly. Oxidative damage is an important mechanism involved in aging.

Gee that about sum up current and projected 273 applications.

#1 shows a huge potential market: Reactive oxidative species (ROS) toxicity remains an undisputed cause and link between Alzheimer’s disease (AD) and Type-2 Diabetes Mellitus (T2DM). Patients with both AD and T2DM have damaged, oxidized DNA, RNA, protein and lipid products that can be used as possible disease progression markers.

Alzheimer has been informally called type 3 diabetes. If 273 works/helps with Type 2 diabetes, the market for 273 doubles. I don't think Anavex has ever discussed this, but it is a logical follow on for myszy studies at least.

[tredenwater2]

Impressive Sokol, thanks for your thoughtful post. Now, if we can just skip the appetiser and announce a Ph 3 Parkinsons prevention trial too based on some sexy Phase 2 precision medicine data that the FDA has been cockblocking for about 3 months now then we would be dancing on glass! Cant really prevent Rett Syndrome but we may be able to fix a bunch of messed up kids and let families return to so much more normal of a live!

Again the FDA needs to get out of their own way Imo! Orphan drug, Priority review voucher, Fast track designation…..I think these are industry alarms that go off letting the big boys know that there is a “fish” that is startjng to swim down the narrow canal now. Unfortunately the canal of approval gets narrower and narrower until the fish seemingly cant turn around and gets stuck just about the time a big harpoon lands right through their mid section ( buyout)! Well, you get the metaphor. All except a few non believer justin biebers

Cheers