This irrefutable mechanistic evidence is what refutes the mineral oil conspiracy and all omega 3's are snake-oil hypothesis: “With this unusual benefit seen in REDUCE-IT, you have to look at it carefully,” Nissen. “It is our belief that it is the comparator that is different. REDUCE-IT used a mineral oil comparator ... we think this is more evidence that REDUCE-IT is a false positive study driven by a comparator that had toxicity.”