Replies to post #377538 on NorthWest Biotherapeutics Inc (NWBO)

[jondoeuk]

Using donar dendritic cells may be a game changer.

Well, it's yet to be, and I know of at least one company https://immunicum.se/technology/ilixadencel/

[biosectinvestor]

It would be a simplified universal Car-T like application, like FATE, but better. You could do off the shelf, dendritic cells.

I have not seen DC’s developed from IPS cells however. And it may be that they are so highly tuned that donor or reprogrammed blank cells are not as useful as the cancer patient’s own cells, which know their specific DNA and therefore won’t target their own healthy tissues. It’s a more complex play on the technology. And it may not be better except in terms of pricing and off the shelf availability. It could be ineffective or even more likely to have negative side effects.

Hard to know. Just a hypothetical at this stage.

[skitahoe]

As the recipient of stem cells I know how difficult it is to get a match, and the complications others cells create even after a great match. I've got a feeling the same will apply here.

If a person can have their own stem cells harvested, then used in the same way donor cells would be, all the complications involved in GVHD are eliminated.

I had a 12 point match, which is as good as it gets, but even today, after 6 years, I have allergic reactions to products that never bothered me before, largely sun screens. At first I thought I was getting burned with almost zero exposure, but then I realized the lotions themselves were making my face feel burned.

If I had to advise someone who had a choice of using their own cells, or someone else's, even if there is a heavy premium on using your own, I suggest paying the added premium. In my case that wasn't possible, in some cases you have to go with a match and worst case I believe they will use a 9 point, and perhaps even an 8 point match in a real emergency.

Gary