Replies to post #299088 on Anavex Life Sciences Corp (AVXL)

[Biostockclub]

Thank you the valuable research, Sokol.


New knowledge is turning the tide in the CNS and now Cancer arenas.


It appears Dr Missling was correct to suggest we could one day ward off many of the effects of aging, previously feared, for good reason.


Jmvho. But, thank you for that DD,
Biostock

[McMagyar]

Thx Sokol

[nidan7500]

Sokol, thanks doing some excellent DD and posting this background information here. We have so many DOTS and so little time.

[abew4me]

Whew...that's a lot to digest Sokol. But well worth the effort!

I've been using Wikipedia to understand and define a lot of the words in your post. One such word that might help others here is: epigenome

Based this portion of your statement:

"The environment directly influences the epigenome and can induce changes that cause or predispose to diseases through risk factors such as stress, malnutrition or exposure to harmful chemicals."

Below is the definition of epigenome from Wikipedia:

epigenome
An epigenome consists of a record of the chemical changes to the DNA and histone proteins of an organism; these changes can be passed down to an organism's offspring via transgenerational stranded epigenetic inheritance. Changes to the epigenome can result in changes to the structure of chromatin and changes to the function of the genome.[1]

The epigenome is involved in regulating gene expression, development, tissue differentiation, and suppression of transposable elements. Unlike the underlying genome, which remains largely static within an individual, the epigenome can be dynamically altered by environmental conditions.

https://en.wikipedia.org/wiki/Epigenome

[RedShoulder]

"Cardiovascular diseases (CVDs) are the number 1 cause of death globally, taking an estimated 17.9 million lives each year."

https://www.who.int/health-topics/cardiovascular-diseases#tab=tab_1

"Epigenetic diseases can either be of monogenic origin or manifest themselves as complex multifactorial diseases such as in congenital heart disease, autism spectrum disorders, or cancer in which mutations in chromatin regulators are contributing factors." (thanks sokol for the very informative post)
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=161837277

"The Sigma-1 Receptor, which is activated by ANAVEX2-73, has demonstrated to restore chromatin structures."

Studies show that changes in the structure of chromatin are responsible for the onset of #AlzheimersDisease.

The Sigma-1 Receptor, which is activated by ANAVEX2-73, has demonstrated to restore chromatin structures.

Learn more: https://t.co/iP67wznIxR pic.twitter.com/kteoCkNMhh

— Anavex Life Sciences (@AnavexLifeSci) February 5, 2021

I agree with the thought here that it is imperative that Anavex get out early on cancer, as well as heart disease which is the number one cause of death globally, before other pharmas beat us to the s-1 patents for these indications.

Quickly organized trials and patent applications for an adjunct treatment for cancer and heat disease would make optimal use of the additional funds recently raised. With 75 Million in the treasury and no debt it could be done, especially knowing that a few million shares for a much higher share price once Rett is producing revenues and the pivotal Alzheimer's trial is well under way to add additional funding as needed.

[falconer66a]

The Anavex chromatin factor to be demonstrated.

The rather recent contention that the Anavex sigma-1 receptor agonists can not only favorably modulate protein folding, thereby treating or preventing a number of central nervous system diseases, but also modulate proper chromatin functioning in genetic expression is immense. Genetic expression is the working of genes, the DNA segments, to ultimately cause biochemical outcomes. It's a complicated process, open to all sorts of problems. Genetic expression must be perfect, or very untoward things happen. Genetic diseases. Chromatin has to precisely operate in the process.

Presently, I can find no actual studies demonstrating that any of the Anavex sigma-1 receptors accomplishing this. I don't, however, question the matter. It will be very interesting to see such information emerge. I'm familiar with how the Anavex molecules can be used, tested for anti-aging outcomes, in various test species (such as the roundworm Ceanorhabditis elegans). But for chromatin studies, any number of organisms, from unicellular protozoans on up to various invertebrates might be test subjects.

Anyone know which organisms might be used to both test and demonstrate this phenomenon? Better, are there any existing chromatin studies involving the Anavex molecules?

If oral administration of blarcamesine, or Anavex 3-71 (at its far more minute dosage concentrations) might comprehensively direct precise gene expression, the applications will be far greater than anything currently envisioned.

Dosing might begin prenatally, before birth, to prevent genetic diseases that result from anomalous gene expression. Rett syndrome might be one of those. There could be hundreds more. All sorts of epigenetic applications.

There very likely would be gigantic applications in animal husbandry, promoting full and favorable gene expression in farm animals.

I'd also like to learn if blarcamesine or Anavex 3-71 (the later, in particular) might, in its low concentrations, facilitate precise genetic transfer in meiosis, the production of functioning, haploid eggs and sperm cells. Could Anavex 3-71 facilitate accurate transfer of genes from the parent on into his or her gametes (sperms and eggs) so as to reduce or prevent genetic errors?

Anavex, please, get some molecular biology grad students to investigate all of this, to get some preliminary indications of applications. If any are positive, the eventual Anavex story will be even larger, significantly changing medicine and human (and animal?) health in the future.

It seems that we are with the Anavex chromatin factor about where we were with the exact mechanism of action (MOA) of blarcamesine five or six years ago — back then very hazy. No longer. May the Anavex chromatin MOA soon come to clarity.

For we biologists, all so exciting. Profound new stuff. None of it in the textbooks yet. Someday....