Replies to post #299103 on Anavex Life Sciences Corp (AVXL)

[tootalljones]

sokol and falconer as usual with serious, important posts. eom.

[sokol]

Falconer, thank you. To answer your question about what organisms could be used doing a studies. Dogs and Cats I think are ideal. Studies could be done for kidney disease. Plus, what do you think a drug would be worth if it could treat pets and extend their lives for their pet owners.

“About 60% of dogs and cats with this disease either die or are humanely euthanized because of failure to respond to supportive care.”

https://bluepearlvet.com/medical-articles-for-pet-owners/acute-renal-failure-in-dogs/

Dogs and Kidney Disease

“Kidney disease is a serious health problem in dogs that require medical attention.”

https://www.thesprucepets.com/dogs-and-kidney-disease-4092948

Chromatin dynamics in kidney development and function

Wibke Bechtel-Walz 1 , Tobias B Huber
Affiliations expand
PMID: 24817101 DOI: 10.1007/s00441-014-1884-y
Abstract

“Epigenetic mechanisms are fundamental key features of developing cells connecting developmental regulatory factors to chromatin modification. Changes in the environment during renal development can have long-lasting effects on the permanent tissue structure and the level of expression of important functional genes. These changes are believed to contribute to kidney disease occurrence and progression. Although the mechanisms of early patterning and cell fate have been well described for renal development, little is known about associated epigenetic modifications and their impact on how genes interact to specify the renal epithelial cells of nephrons and how this specification is relevant to maintaining normal renal function. A better understanding of the renal cell-specific epigenetic modifications and the interaction of different cell types to form this highly complex organ will not only help to better understand developmental defects and early loss of kidney function in children, but also help to understand and improve chronic disease progression, cell regeneration and renal aging.”

https://pubmed.ncbi.nlm.nih.gov/24817101/

[frrol]

No. These are theories and postulates. The S1 receptor is not a magic chromatin fixer, nor is 2-73 is a magic bean chromatin fixer. Nor are "we biologists".

There's some research that links chromatin dysfunction. Like a lot of AD research it has a long way to go and is not necessarily true or complete. Actual biologists and researchers know this, so no one should be misled.

Keep an eye out for possible BTD for Rett. If not in the next 4-5 weeks, we will have another and likely better chance after the AVATAR results.

[makemydaze]

It's pretty hard to wrap your head around the big picture regarding the potential uses for 2-73. In regard to the Gaba/Glutamate ratio correction that occurred in the first Rett trial now there's a study out that says a better ratio results in better decision making -

“Our results show a correlation between decision-making behaviour and the balance of two messenger substances in the brain. People with a higher ratio of excitation to inhibition in dACC need a bigger incentive to move away from their status quo. By contrast, people with more GABA in vmPFC exhibit greater accuracy for short-term decisions.”

https://neurosciencenews.com/gaba-glutamate-decision-making-17731/

Can we pipe this stuff into the water supplies feeding Wash DC?

[ChrisMissing]

Falcon, maybe this is the reason why Anavex has been unbelievably quiet with a lot of their data over the years. They know what they have and for competitive reasons they chose not to discuss some of it like this portion of it.