Replies to post #353089 on NorthWest Biotherapeutics Inc (NWBO)

[biosectinvestor]

Very thorough post highwayman! Thank you!

[danielboog2]

Thank you...Enlightening for sure.

[iwasadiver]

Beautiful

[foxhound02]

The question at hand is why TLD have not been announced? The article correctly points out that publication is often delayed. I know the view of some here is that TLD and publication will occur at the same time. This is not typical and I do not know an example of it ever happening.

[Dr Bala]

Awesome post.

[learningcurve2020]

So why did leadership have everyone convinced TLD would be in July?

[eagle8]

Thamk you highwayman4life for this post.

Best to you.

[skitahoe]

Thanks Highwayman,

I'd like to ask the board moderators to sticky this post.

Gary

[greenJack]

Awesome is the word!

[xoma4578]

Awesome work, HwyMan4Life!!

[The Danish Dude]

Sticky. Absolutely!

[Basin Street Blues]

Thanks Highwayman - BUT I end up thinking we are comparing apples and pears looking at the
1 year mean to full data release the article talks about.

First off i’d imagine as tech has positively impacted they way data is collated has improved even if the average time for full data set exposition is 12 months , i’d imagine that it is moving to the right along the curve so to speak and its probably between 6-9 months till full data release these days( ie when its discussed at conference )

I have an alert that shows every clinical PR the uses the term ‘endpoint’ for well over a year nd have found that
when the ‘endpoint ‘ is reached or not is part of the TLD PR and then as we know details discussed later at XYZ. conf... Every time one of there PR’s has been reported I have then looked at when they data locked , and i’ve never seen one that took a year till the full data set was in the public domain .

Typically its data lock , it seems about 2 months till TLD , and then literally the data is discussed at the next relevant conference which occurs normally <6 months post DL.

For us the medical journals we hope for are far more frequent than waiting for a major conference , certainly the Lancet is weekly, therefore I hope what we loose in time between DL and TLD because of the complexity of the data and covid 19 is made up for in time not having to wait for a major conference .

I think net net its reasonable to expect TLD anytime from now especially considering the guidelines that so many share holders were given of 2-8 weeks for TLD from DL.

[HappyLibrarian]

This really shows the negative impact on ordinary shareholders of tacking on a journal article to an already protracted process of releasing TLD because we will need another heavy dilution at low prices during this long wait.

No one asked for this article and another delay and this is clearly just more of the same from management because remember they said they expected September 2019 which meant they were either lying because with an article that was impossible or they made pursuing this supposedly essential article a last minute unwelcome addition to the process.

[Hopeforthefuture3]

Highwayman4, Thanks for the information that I find most discouraging for shareholders and more so for patients. If per the cited paper it takes median of 300 days to get data published, and nwbo intends no tld until publication then we may get tld say this August (2021) perhaps? Seems a far cry from when most of us watched Powers (early September 2020) in a luncheon presentation say September of 2020 for data to be released. Guess my coworker that passed from gbm never had a chance of any hope that dcvax-l might help. Same for my good friend's relative diagnosed last fall with gbm. Back in 2018 (or 2017) when they hit targeted # of events hoped might be approved and the standard by now.
That poor can has now been kicked so many times it now may resemble a smashed can.

Thankfully for my portfolio most of the companies I own stock in progress much quicker.
Just read the past year of press releases on another company -AVDL- and they like many others i have chose a much faster path. Imo AMRN was a great example of getting all the pieces together in a timely fashion tld in September and detailed presentation and NEJM paper a couple months later. Approval of course took well into the following year.
If nwbo really wants a published paper to go with tld could always make it a lot faster by using JTM again - not a high impact journal but certainly quick. Who knows...someday just no idea when that day will be. The poor patients hope they can get on a clinical trial
Good luck

[Doc logic]

highwayman4life,

Great, well thought out post. As you probably know, I do not believe extra time now delays the time to approval and may actually be lining up news into a much tighter time frame. I do believe that if a journal does not prioritize this research for publication to speed up the process that they are foot dragging as the length of this trial alone makes this a historic moment in GBM research and cancer research in general as a platform technology applicable to all solid tumors now and, when modified, to blood and diffuse cancers as well. Best wishes.

[pqr]

Well done thanks. GLTAL