I have well over 50 patents and I have never had the US Patent Office accept the claims on the first submission. It is their modus operandi to reject the first set of claims and site other patents or prior art and claim that your claims are obvious over these references. In some case they may very well find prior art that renders your patent moot, but it is far more likely that you need to reword or narrow some of the claims and also make a compelling case as to why you deserve a patent. I think in all the patents I have filed there is only 1 instance where they came back with a prior art reference that was exactly like what I had submitted so I threw in the towel on that one. All the others I was able to obtain a patent with good meaningful claims.
If DCVax-L TLD is good, people will possibly turn to DCVax-Direct in droves and look into it more carefully with different glasses, including competitors of course. Probably NWBO already realized this and wanted some protection of its intellectual properties while competitors are still sleeping. I agree with you Flip and others probably also already realized what the potential value DCVax-Direct would bring to the table once DCVax-L is validated and results are good as we expected. Those BPs would find out and probably would send out their smartest scientists to look into this field. We NWBO investors would certainly sleep better knowing the next biggest potential science has been properly patented in the “cookie jar”.