Replies to post #122173 on Cytodyn Inc (CYDY)

[moneycrew]

Cytodyn showed zero viral indicators after 3 days in a study, why would it be not needed? Did the article specifically say " Leronlimab is not needed?"

[daemon57]

DR Jerry - that was a great find and read. Thank you.
Agree with you that we need to get and ready the BLA submission for HIV.

For other DR's and scientists, what's your thought on the very last paragraph of the page:

"For this reason, Kishimoto said, "SARS-CoV-2 infection causes critical illness and severe dysfunction in respiratory organs and induces a cytokine storm," even in the setting of lower but still elevated serum IL-6 levels." ?

Isn't that exactly the subset that is our CD12 population?

GLTU/A.

[Whosonfirst]

DR Jerry is not a trusted DR. Should we all start taking medication you suggest?

[Whosonfirst]

Thank You. Dr Patterson and other labs have verified zero Viral load ZERO after taking Leronlimab. I guess you were trying to say that theyare looking at all drugs that prove Positive clinical Results Especially MAB’s. They are the talk of the town/world!

[smokeandmist]

Dr Patterson’ s paper notes its “disruption of the CCL5-Rantes-CCL5 axis restores immune homeostasis”

[Dr Zaius]

Tadamitsu Kishimoto, MD, PhD, of the Department of Immune Regulation at the Immunology Frontier Research Center at Osaka University, Osaka, Japan disagrees with your theory,

"His study, published online August 21 in PNAS, also revealed lower serum IL-6 levels among people with COVID-19 compared to patients with bacterial ARDS or sepsis.

Kishimoto drew a distinction, however: COVID-19 patients can develop severe respiratory failure, suggesting a distinct immune reaction compared to patients with bacterial sepsis. SARS-CoV-2 directly infects and activates endothelial cells rather than macrophages, as occurs in sepsis.

For this reason, Kishimoto said, "SARS-CoV-2 infection causes critical illness and severe dysfunction in respiratory organs and induces a cytokine storm," even in the setting of lower but still elevated serum IL-6 levels.

Dr. Kishimoto's study is much more robust (N=127 vs N=46) than the study referenced in Medscape. The study is more comprehensive and nuanced than the Dutch study and debunks it immediately.

https://www.pnas.org/content/117/36/22351

Antivirals do not work for everyone and are susceptible to failure once the virus mutates.

I conclude that it appears certain that Leronlimab will be needed for severe/critical patients.

Nader should continue to focus on CD12 while keeping the ball rolling on the HIV BLA.

[EmotionalBuyer]

Dr. Sorry to ask you a simple question. I could not find any reference to CCR5 or CCL5 in the doc you refer to. Can you explain to me how this finding affect LL. I am not in med field and these look like Martian to me.

[Amatuer17]

This is an interesting find.

The other important point is - how it affects Lero? Dr BP mentioned this as a RANTES disease and Lero works on RANTES through CCR5

So next weeks S2C results are very important - they may not be as good as NP is hoping and everyone including me are hoping.

Lero may have right impact on CCR5 and RANTES but does RANTES improves Covid?

In mild to moderate - viral load may be important but later it may be different