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meirluc

09/12/20 9:33 PM

#306883 RE: skitahoe #306835

skitahoe, maybe someone should enlighten me but how can we be certain that hardlock has not alreadsy been invoked when:

1. All 80+ sites had signed off more than a month ago.
2. The outside contractors (most likely those determining the type of
IDH mutation) completed their work more than 3 weeks ago.
3. Recently we found out that on 11/20/20 Drs LL and B will present at
an SNO PLENARY session.
4. Today LP told us that within 18 days NWBO plans to reveal TLD.

Obviously NWBO had plenty of time to go over the results received from clinical sites, contractors etc. Also by late August, SNO most likely received enough unblinded result information that justified a presentation at an SNO plenary session on 11/20/20.

If all this transpired without a hard data lock, then this last step leading to TLD does not seem to have much meaning. With TLD at most 18 days away, would a PR of a hard DL be very significant?

Regarding your question that you asked yesterday about the content of my post 306504, I believe that you misunderstood me.

I wrote that 56 or somewhere between 50-60 patients of the entire trial (331 patients) may still be alive today. I think you thought that I meant that 56 of the most recently enrolled 108 patients are alive today and that would imply that there are additional survivors originating from earlier enrolled patients. That would mean that 70+ patients could still be alive today. Wish that was true but I believe the number of present day survivors will be maximum 60 patients and will be probably less than that.