HK..."The line between moderate and severe TG elevation is arbitrary and not driven by any underlying science " tHIS IS...ERROR BY JUDGE DU..yOU NAILED IT.
Correct - using the term two populations is sort of misleading. It’s a continuum and the higher your triglycerides, the more TG lowering drugs raise LDL. It’s a linear relationship according to a POSA in 2008. EPA breaks with the traditional understanding that this was linear for all TG lowering drugs. The reason >500 was used is because we dichotomize populations in studies to have either >500 or <500 since that generally captures the individuals with very different goals of treatment and responses to treatment. It was never meant to imply a strict cutoff but FDA requires such a cutoff for studies and labels. So it’s really a regulatory and investigational cutoff, not a biological cutoff.
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