Replies to post #281297 on Amarin Corp Plc (AMRN)

[HinduKush]

... The reason >500 was used is because we dichotomize populations in studies to have either >500 or <500 since that generally captures the individuals with very different goals of treatment and responses to treatment...

Agreed. There is acontinuum of transition that reflects in this arbitrary but important cut point, just as we arbitrarily divide day and night at dusk, buy nevertheless perform different tasks at these two times. Du's error was to extrapolate tenuous statistical data regrading TG lowering behavior of EPA vs. DHA from a mildly hypertriglyceridemic population such as Mori or Krabayashi (or to use the miniscule number of TG>400mg/dl patients in Hayashi) to absurdly and peversely justify an obviousness argument in a totally different therapeutic population. Today we scrutinize large multicenter trials (like R-IT) for proportions of male to female, diabetics etc to ensure broad therapeutic deductions on applicability are appropriate,...even though we could be peverse and say what was good for one is good for the other...
HK