Replies to post #262385 on Amarin Corp Plc (AMRN)

[amarininvestor]

No, I am not. I know / saw both of them. The ss change in the EPA + e arm is enough for hypothesis.

Not sure I agree with that HDG, you cannot take a piece of data in isolation for hypothesis generation:

- If you have a statistical significant difference between arm, you can hypothesize that EPA alone may reduce ApoB
-If you have a change (either direction) in the arm that you combine with another lipid modifying agent (estriol) you cannot reasonable make the hypothesis that EPA reduces ApoB without comparing to your control arm. Maybe in the legal-world or patent-world that is OK but there is no way in my mind that a POSA would find that conclusion reasonable neither would find that sufficient for hypothesis generation

[circuitcity]

Hdg, rmitra, amarinvestor,

I agree with Amarininvestor here. A similar exercise like rmitra did on Mori could be useful here, if rmitra is kind enough to do this.

[jomama9231]

How G? Look at that table. All comparisons even within the epa estriol group are not ss except until you get to 48 weeks. That has to lose a lot of credibility. Also it is no where In discussion or conclusion of article. I don’t think this is hypothesis generating.

[Piyao]

Comparing baseline and one of the arm to detect the statistic significance is meaningless, it totally invalidate the foundation of A/B testing.

https://www.nature.com/articles/s41393-018-0203-y

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3286439/